“…[7] The need for evidence-informed and cost-efficient healthcare is urgent, and CPGs produced for local needs in these countries may have compromised quality and credibility and fail to meet international reporting standards for CPGs. [8] We have previously examined critical components of good-quality CPGs, [9] the potential of dedicated projects such as South African Guidelines Excellence (SAGE) to better understand the development, implementation and use of CPGs in SA primary care settings, [10] and the construction and management of effective, efficient and outcome-focused CPG teams. [11] An alternative approach to CPG development is proposed that involves adopting, contextualising or adapting existing CPGs to suit local purposes.…”