The increased demand for higher education in recent years has thrown into question the issue of quality service. The purpose of this study was to investigate the factors that students perceive as the determinants of quality education service in selected public universities in Ghana. Using a convergent parallel mixed-methods design, data were collected from 606 final year education students for the 2020/2021 academic year while six students were interviewed. From both quantitative and qualitative data, the study found that students perceived their universities to have a high SSR. Also, the quantitative data showed that there is a statistically significant difference in the perceived student-staff ratio scores in the three selected public universities. Finally, the study revealed that students' entry background characteristics such as gender, the programme of study, and age, and institutional factors (such as the personality of the teaching staff, academic factors, administrative systems, and SSR influenced quality education delivery rating (low, or high perceptions) of students. In view of the findings, the study advocated that since the educational enterprise is in competition, public universities should adopt innovative approaches to attract the mass of students wanting to enroll with them in the face of the global educational competition.