Soursop fruit extract mitigates scopolamine-induced amnesia and oxidative stress via activating cholinergic and Nrf2/HO-1 pathways

omairi, Naif E. Al; Albrakati, Ashraf; Kassab, Rami B.; Lokman, Maha S.; Elmahallawy, Ehab Kotb; Amin, Hatem K.; Moneim, Ahmed E. Abdel

doi:10.1007/s11011-019-00407-2

Cited by 22 publications

(6 citation statements)

References 70 publications

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“…Perhaps, cadmium accumulation in the liver led to its binding with the sulfhydryls group of GSH and limited the expansive reductive actions of GSH [ 68 ]. This further weakened the antioxidant defense system of the body leading to overproduction of reactive oxygen species (ROS) [ 69 ], which subsequently enhanced lipid peroxidation evidenced with significant elevation of MDA observed in this present study. MDA is a product of lipid peroxidation due to elevation of ROS in the physiological system and particularly in tissues [ 2 , 69 ].…”

Section: Discussionmentioning

confidence: 81%

“…This further weakened the antioxidant defense system of the body leading to overproduction of reactive oxygen species (ROS) [ 69 ], which subsequently enhanced lipid peroxidation evidenced with significant elevation of MDA observed in this present study. MDA is a product of lipid peroxidation due to elevation of ROS in the physiological system and particularly in tissues [ 2 , 69 ]. Cd is also known to increase MDA in the physiological system [ 2 , 67 ].…”

Section: Discussionmentioning

confidence: 81%

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Hesperidin ameliorates hepatic dysfunction and dyslipidemia in male Wistar rats exposed to cadmium chloride

et al. 2020

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Section: Discussionmentioning

confidence: 81%

Section: Discussionmentioning

confidence: 81%

Hesperidin ameliorates hepatic dysfunction and dyslipidemia in male Wistar rats exposed to cadmium chloride

et al. 2020

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“…When fruit extract was applied concomitantly to copper, the AChE activity in all groups of fruit extract was normalized, suggesting that pitaya could assist the nervous system in coping with Cu‐induced toxicity. AChE alterations are related to the degeneration of cholinergic synapses and subsequent cholinergic transmission dysfunction, which results in Alzheimer's disease progression (Al omairi et al, 2019).…”

Section: Discussionmentioning

confidence: 99%

Neuroprotective and antioxidant effects of pitaya fruit on Cu‐induced stress in adult zebrafish

Tamagno

Santini

Alves

et al. 2022

Journal of Food Biochemistry

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The harmful effects of heavy metals on organisms have not been fully described. At present, there is a close relationship between neurodegenerative diseases and copper toxicity. In addition, the copper effect on the central nervous system is followed by high levels of free radicals in different body tissues. An increase in free radical levels leads to aging-related diseases, resulting in the appearance of senile comorbidities.An increase in the consumption of natural compounds that could help to reduce this dangerous effect on organisms was observed. Pitaya (Hylocereus undatus) is a tropical fruit with great antioxidant potential and can help the organism with oxidative damage. This study evaluated the effect of H. undatus on zebrafish organisms in front of copper-induced toxicity. Therefore, the behavior, cholinergic system, antioxidant enzymes, and ALAD activity were evaluated as biomarkers. Our results highlight the great potential of Pitaya's pulp to reduce the levels of anxiety and aggressivity in fish and reduce cortisol levels. It could mediate the normal response of the cholinergic nervous system, antioxidant enzymes, and ALAD activity. Therefore, our data suggest that pitaya might improve the senile aging. Practical applicationsThe potential practical application of this study is related to the neuroprotective effect of the Hylocereus undatus microencapsulated pulp extract against metal-induced impairments. The results have shown that this extract is able to reduce the copperinduced damage modulating the antioxidant system and the cholinergic nervous system. One of the implicated potentials of use for this extract is the food supplementation to its fortification.

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“…The antioxidant properties of this herb are attributed to the presence of the polyphenols and avonoids [16]. These constituents bolster antioxidant defenses in a variety of pathophysiologic conditions characterized by oxidant/antioxidant imbalance [17]. Anti-in ammatory and antiapoptotic effects of S. lappa are reported [18,19].…”

Section: Introductionmentioning

confidence: 99%

Cytotoxic and Anti-excitotoxic Effects of Selected Plant and Algal Extracts Using Comet and Cell Viability Assays

Al-Dbass

Amina

Musayeib

et al. 2020

Preprint

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Excess glutamate in the central nervous system may be a major cause of neurodegenerative diseases with gradual loss and dysfunction of neurons. Primary or secondary metabolites from medicinal plants and algae show potential for treatment of glutamate-induced excitotoxicity. Three plant extracts were evaluated for impact on glutamate excitotoxicity-induced in primary cultures of retinal ganglion cells. These cells were treated separately in seven groups: control; Plicosepalus. curviflorus treated; Saussurea lappa treated; Cladophora glomerate treated. Cells were treated independently with 5, 10, 50, or 100 µg/ml of extracts of plant or alga material, respectively, for 2 h. Glutamate-treated cells (48 h with 5, 10, 50, or 100 µM glutamate); and P. curviflorus/glutamate; S. lappa/glutamate; C. glomerata/glutamate [pretreatment with extract for 2 h (50 and 100 µg/ml) before glutamate treatment with 100 µM for 48 h]. Comet and MTT assays were used to assess cell damage and cell viability. The number of viable cells fell significantly after glutamate exposure. Exposure to plant extracts caused no notable effect of viability. All tested plants extracts showed a protective effect against glutamate excitotoxicity-induced RGC death. Use of these extracts for neurological conditions related to excitotoxicity and oxidative stress might prove beneficial.

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Soursop fruit extract mitigates scopolamine-induced amnesia and oxidative stress via activating cholinergic and Nrf2/HO-1 pathways

Cited by 22 publications

References 70 publications

Hesperidin ameliorates hepatic dysfunction and dyslipidemia in male Wistar rats exposed to cadmium chloride

Hesperidin ameliorates hepatic dysfunction and dyslipidemia in male Wistar rats exposed to cadmium chloride

Neuroprotective and antioxidant effects of pitaya fruit on Cu‐induced stress in adult zebrafish

Cytotoxic and Anti-excitotoxic Effects of Selected Plant and Algal Extracts Using Comet and Cell Viability Assays

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