Sources of Processed Lipoaspirate Cells: Influence of Donor Site on Cell Concentration

Padoin, Alexandre Vontobel; Silva, Jefferson Braga; Martins, Pedro Djacir Escobar; Rezende, Katia; Rezende, Antonio Roberto da Rosa; Grechi, Bianca; Gehlen, Daniel

doi:10.1097/prs.0b013e31817d5476

Cited by 154 publications

(90 citation statements)

References 25 publications

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“…Although reports in the literature (Padoin et al, 2008) suggest the lower abdomen and inner thighs to be richer in the source of stem cells, this study used C-Kit expression as a proxy measurement for stem cells. C-Kit expression also measures lymphocytes and on this basis the conclusions of this paper are in question.…”

Section: Fat Harvestingmentioning

confidence: 99%

Autologous Fat Transplantation – A Paradigm Shift in Breast Reconstruction

Vecchio¹,

Fichadia²

2012

Breast Reconstruction - Current Techniques

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Section: Fat Harvestingmentioning

confidence: 99%

Autologous Fat Transplantation – A Paradigm Shift in Breast Reconstruction

Vecchio¹,

Fichadia²

2012

Breast Reconstruction - Current Techniques

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“…Regardless of, whether there is an optimal donor site, experts suggest, that some sites may be preferable to others. Some studies have shown that lower abdominal fat contains more stem cells compared to other areas [45]. Fat survival can depend on the count of stem cells, which support the graft through adipogenesis and angiogenesis [46,47].…”

Section: Cd3mentioning

confidence: 99%

Fat graft – the natural choice for reconstructive, regenerative and aesthetic surgery

Ibrahim¹,

Rybacka-Mossakowska²,

Michalak³

2017

Advances in Cell Biology

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The search for appropriate filler, which can be used for aesthetic and reconstructive operations is currently one of challenges for plastic surgery. The application of absorbable and permanent artificial fillers may cause adverse events. Thus, autologous fat grafting can be a safe alternative. Moreover, fat tissue is rich in adipose-derived stem cells (ASC), which can be successfully used for regenerative procedures. The paper reviews reports on fat grafting procedures, which indicate risks and their possible prophylactic. Adipose tissue is a much more prolific source of ASCs than bone marrow. Basically, ASC are characterized by a spectrum of markers: CD11b-CD45-CD13+CD73+CD90+, which can be widened by CD36+CD-106-CD10+CD26+CD49d+CD49e+CD3-D49f -PODXL-to improve phenotyping. It is suggested to use at least two negative markers and two positive markers during the same phenotyping analysis. Fat transfer requires appropriate approach, planning and technique to make it clinically successful. Fat grafting fulfills the expectations for ideal injectable agent, which can be used for aesthetic and reconstructive surgery. To improve the survival of fat graft, careful decisions on donor site, local anesthetic administration, liposuction method, processing and placement methods need to be made. Moreover, fat is the source of adipose-derived stem cells which can be used for regenerative procedures. A proper transformation and identification of those cells is required to improve clinical effects.Running title: Fat graft -The natural choice for plastic surgery

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“…Tissue engineering (TE) has looked for the combined use of regenerative cells, matrices or cell carriers, and growth factors (GF) 1,[22][23][24][25][26][27][28][29][30][31][32][33] . There are some controversial evidences showing lack in cranial vault reconstructions when ADSCs are used 34,35 .…”

mentioning

confidence: 99%

Cranial vault reconstruction with bone morphogenetic protein, calcium phosphate, acellular dermal matrix, and calcium alginate in mice

et al. 2014

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Sources of Processed Lipoaspirate Cells: Influence of Donor Site on Cell Concentration

Abstract: The lower abdomen and the inner thigh may have higher processed lipoaspirate cell concentrations. These sites may turn out to be better sources of adult mesenchymal stem cells.

Cited by 154 publications

References 25 publications

Autologous Fat Transplantation – A Paradigm Shift in Breast Reconstruction

Autologous Fat Transplantation – A Paradigm Shift in Breast Reconstruction

Fat graft – the natural choice for reconstructive, regenerative and aesthetic surgery

Cranial vault reconstruction with bone morphogenetic protein, calcium phosphate, acellular dermal matrix, and calcium alginate in mice

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