Sources, occurrence and toxic effects of emerging per- and polyfluoroalkyl substances (PFAS)

Manojkumar, Y.; Pilli, Sridhar; Rao, P. Venkateswara; Tyagi, Rajeshwar Dayal

doi:10.1016/j.ntt.2023.107174

Cited by 44 publications

(14 citation statements)

References 89 publications

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“…PFAS are classes of organofluorine compounds widely used in both industrial and consumer applications. From a chemical standpoint, PFAS offer numerous advantages—such as high inertness due to the strength of their carbon-fluorine bonds—but they come with a significant drawback: unfavorably long half-lives within environmental and biological systems ( 4 ). Recent monitoring studies have confirmed the pervasive presence of PFAS in water and land environments, as well as in aquatic species at all levels of the food web.…”

Section: Pfasmentioning

confidence: 99%

Molecular Imaging, Radiochemistry, and Environmental Pollutants

Delaney,

Sebastiano,

Zeglis

et al. 2023

J Nucl Med

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The worldwide proliferation of persistent environmental pollutants is accelerating at an alarming rate. Not surprisingly, many of these pollutants pose a risk to human health. In this review, we examine recent literature in which molecular imaging and radiochemistry have been harnessed to study environmental pollutants. Specifically, these techniques offer unique ways to interrogate the pharmacokinetic profiles and bioaccumulation patterns of pollutants at environmentally relevant concentrations, thereby helping to determine their potential health risks.

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Section: Pfasmentioning

confidence: 99%

Molecular Imaging, Radiochemistry, and Environmental Pollutants

Delaney,

Sebastiano,

Zeglis

et al. 2023

J Nucl Med

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“…The synthetically-made industrial chemicals per- and polyfluoroalkyl substances (PFAS) have been marketed since the 1940s and have been extensively used since the 1950s in a wide variety of applications [ 1 ]. According to the U.S. National Institute of Environmental Health Sciences, there are some 15,000 different PFAS molecules, but hundreds of newer and previously unreported PFAS and PFAS-related compounds –the so-called “emerging” PFAS– continue to be identified by researchers [ 2 , 3 ].…”

Section: Introductionmentioning

confidence: 99%

“…Since the carbon-fluorine bond is among the strongest ones, PFAS have a high resistance to degradation. This makes them industrially valuable, especially in applications at high temperatures or high pressures or in corrosive environments [ 1 – 3 ].…”

Section: Introductionmentioning

confidence: 99%

All-cause, cardiovascular disease and cancer mortality in the population of a large Italian area contaminated by perfluoroalkyl and polyfluoroalkyl substances (1980–2018)

Biggeri,

Stoppa,

Facciolo

et al. 2024

Environ Health

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Background Per- and polyfluoroalkyl substances (PFAS) are associated with many adverse health conditions. Among the main effects is carcinogenicity in humans, which deserves to be further clarified. An evident association has been reported for kidney cancer and testicular cancer. In 2013, a large episode of surface, ground and drinking water contamination with PFAS was uncovered in three provinces of the Veneto Region (northern Italy) involving 30 municipalities and a population of about 150,000. We report on the temporal evolution of all-cause mortality and selected cause-specific mortality by calendar period and birth cohort in the local population between 1980 and 2018. Methods The Italian National Institute of Health pre-processed and made available anonymous data from the Italian National Institute of Statistics death certificate archives for residents of the provinces of Vicenza, Padua and Verona (males, n = 29,629; females, n = 29,518) who died between 1980 and 2018. Calendar period analysis was done by calculating standardised mortality ratios using the total population of the three provinces in the same calendar period as reference. The birth cohort analysis was performed using 20–84 years cumulative standardised mortality ratios. Exposure was defined as being resident in one of the 30 municipalities of the Red area, where the aqueduct supplying drinking water was fed by the contaminated groundwater. Results During the 34 years between 1985 (assumed as beginning date of water contamination) and 2018 (last year of availability of cause-specific mortality data), in the resident population of the Red area we observed 51,621 deaths vs. 47,731 expected (age- and sex-SMR: 108; 90% CI: 107–109). We found evidence of raised mortality from cardiovascular disease (in particular, heart diseases and ischemic heart disease) and malignant neoplastic diseases, including kidney cancer and testicular cancer. Conclusions For the first time, an association of PFAS exposure with mortality from cardiovascular disease was formally demonstrated. The evidence regarding kidney cancer and testicular cancer is consistent with previously reported data.

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“…However, the use of pentafluorophenol-activated ester suffers from the formation of highly toxic and polluting byproduct during the PPM reaction. 29 Cyclic bottlebrush polymers were also obtained from a cyclic poly(norbornene imide) backbone (DP n ∼1900) with clickable triazolinedione (TAD)-diene side groups through a double PPM according to a "grafting-onto" strategy using TAD-terminated polymers obtained by reversible addition-fragmentation chain transfer (RAFT) polymerization. 25 Considering the broad spectrum of distinct properties attributed to cyclic polymers and the efficacy of the PPM strategy in generating a spectrum of functional polymers from a single scaffold, a necessity arises to develop a clickable reactive platform.…”

Section: ■ Introductionmentioning

confidence: 99%

A Versatile Cyclic Clickable Platform by Ring-Expansion Metathesis Polymerization: Cyclic Glycopolymers with Lectin-Binding Ability

Gonnot,

Scalabrini,

Roubinet

et al. 2024

Macromolecules

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A new versatile cyclic polymer platform for the design of advanced cyclic materials was prepared by combining ring-expansion metathesis polymerization (REMP) and click chemistry. Cyclic poly(norbornenyl azlactone) backbones were synthesized over an unprecedented length range with number-average degree of polymerization (DP n ) ranging from 25 to 1000. The cyclic topology was thoroughly characterized using 1H NMR, size exclusion chromatography (SEC) with multiangle light scattering (MALS) and viscometer detection. Postpolymerization modification (PPM) of these scaffolds was carried out with amino-terminated mannoses using the click aminolysis of the azlactone moiety to prepare a library of multivalent cyclic glycopolymers. The binding inhibition of the resulting cyclic glycopolymers was assessed against a panel of model and biologically relevant lectins (Bc2L-A, FimH, langerin, DC-SIGN, and ConA). The cyclic carbohydrate-functionalized polynorbornenes exhibited high lectin-binding inhibitory potency in the biochip assay, surpassing their monovalent analogues by several orders of magnitude and competing strongly with their linear polymer analogues in terms of IC50 values. Interestingly, the cyclic polymers also prevented the adhesion of Adherent-Invasive Escherichia coli implied in Crohn’s disease, to intestinal cells.

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Sources, occurrence and toxic effects of emerging per- and polyfluoroalkyl substances (PFAS)

Cited by 44 publications

References 89 publications

Molecular Imaging, Radiochemistry, and Environmental Pollutants

Molecular Imaging, Radiochemistry, and Environmental Pollutants

All-cause, cardiovascular disease and cancer mortality in the population of a large Italian area contaminated by perfluoroalkyl and polyfluoroalkyl substances (1980–2018)

A Versatile Cyclic Clickable Platform by Ring-Expansion Metathesis Polymerization: Cyclic Glycopolymers with Lectin-Binding Ability

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