Sources, health benefits, and biological properties of zeaxanthin

Bouyahya, Abdelhakim; Omari, Nasreddine El; Hakkur, Meryem; Balahbib, Abdelaali; Guaouguaou, Fatima-Ezzahrae; Rebezov, Мaksim; Максимюк, Николай Несторович; Shariati, Mohammad Ali; Zengin, Gökhan; Menyiy, Naoual El; Chamkhi, Imane; Bakrim, Saad

doi:10.1016/j.tifs.2021.10.017

Cited by 48 publications

(17 citation statements)

References 155 publications

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“…Therefore, researchers have been searching for alternatives to conventional antibiotics. Within this context, natural substances, particularly those extracted from medicinal plants, constitute a source of drugs against various pathologies, including diabetes, cancer, inflammation, and pathologies linked to stress and microbial infections [ 1 , 2 , 3 , 4 , 5 , 6 , 7 , 8 , 9 , 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 ]. The antibacterial activity of these natural products is linked to different mechanisms of action, such as the increase in membrane permeability, the decrease in membrane integrity, and the disruption of efflux pumps [ 10 , 13 , 18 , 19 ].…”

Section: Introductionmentioning

confidence: 99%

Mechanisms, Anti-Quorum-Sensing Actions, and Clinical Trials of Medicinal Plant Bioactive Compounds against Bacteria: A Comprehensive Review

et al. 2022

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Bacterial strains have developed an ability to resist antibiotics via numerous mechanisms. Recently, researchers conducted several studies to identify natural bioactive compounds, particularly secondary metabolites of medicinal plants, such as terpenoids, flavonoids, and phenolic acids, as antibacterial agents. These molecules exert several mechanisms of action at different structural, cellular, and molecular levels, which could make them candidates or lead compounds for developing natural antibiotics. Research findings revealed that these bioactive compounds can inhibit the synthesis of DNA and proteins, block oxidative respiration, increase membrane permeability, and decrease membrane integrity. Furthermore, recent investigations showed that some bacterial strains resist these different mechanisms of antibacterial agents. Researchers demonstrated that this resistance to antibiotics is linked to a microbial cell-to-cell communication system called quorum sensing (QS). Consequently, inhibition of QS or quorum quenching is a promising strategy to not only overcome the resistance problems but also to treat infections. In this respect, various bioactive molecules, including terpenoids, flavonoids, and phenolic acids, exhibit numerous anti-QS mechanisms via the inhibition of auto-inducer releases, sequestration of QS-mediated molecules, and deregulation of QS gene expression. However, clinical applications of these molecules have not been fully covered, which limits their use against infectious diseases. Accordingly, the aim of the present work was to discuss the role of the QS system in bacteria and its involvement in virulence and resistance to antibiotics. In addition, the present review summarizes the most recent and relevant literature pertaining to the anti-quorum sensing of secondary metabolites and its relationship to antibacterial activity.

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Section: Introductionmentioning

confidence: 99%

Mechanisms, Anti-Quorum-Sensing Actions, and Clinical Trials of Medicinal Plant Bioactive Compounds against Bacteria: A Comprehensive Review

et al. 2022

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“…In addition, this implies that the absorption of zeaxanthin may require a concomitant higher intake of lipids, which may explain the lower bioaccessibility of WAT and WIN. In addition, zeaxanthin may interact with other carotenoids, and has been reported to reduce the bioavailability of flavonoids [ 30 ]. Another possibility is that the fruit cell wall underwent extensive degradation in the gastric phase after exposure to strong acids and digestive enzymes, resulting in small fluctuations in their bioaccessibility in the intestinal phase.…”

Section: Resultsmentioning

confidence: 99%

Assessment of the Bioaccessibility of Carotenoids in Goji Berry (Lycium barbarum L.) in Three Forms: In Vitro Digestion Model and Metabolomics Approach

Ying

Liu

et al. 2022

Foods

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Goji berry (Lycium barbarum L., LBL) is a good source of carotenoids, while the bioaccessibility of various types of LBL carotenoids has not been explored. In the study, eight carotenoids, three carotenoid esters and two carotenoid glycosylated derivatives were identified by a non−targeted metabolomics approach. The dried LBL (DRI), LBL in water (WAT), and LBL in “Baijiu” (WIN) were used to recreate the three regularly chosen types of utilization, and the in vitro digestion model showed that the bioaccessibility of the carotenoids increased significantly from the oral to the gastric and intestinal phase (p < 0.05). The bioaccessibility of LBL carotenoids was the most elevated for DRI (at 28.2%), followed by WIN and WAT (at 24.9% and 20.3%, respectively). Among the three carotenoids, zeaxanthin dipalmitate showed the highest bioaccessibility (51.8–57.1%), followed by β−carotene (51.1–55.6%) and zeaxanthin (45.2–56.3%). However, the zeaxanthin from DRI exhibited significantly higher bioaccessibility (up to 58.3%) than WAT and WIN in both the gastric and intestinal phases (p < 0.05). Results of antioxidant activity tests based on DPPH, FRAP, and ABTS showed that the addition of lipids improved the bioaccessibility of the carotenoids. (p < 0.05).

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“…Together with lutein, zeaxanthin accumulates in the cornea as a macular pigment, protecting the retinal membrane from blue light and improving visual acuity [24]. Zeaxanthin also has potentials as an antioxidant, anti-inflammatory and for preventing neurological disease [20]. Maize, orange peppers and cooked scallions are good choices for dietary intake, while their contents are relatively as low at 16.3, 16.7 and 24.9 µg/g, respectively [13,22].…”

Section: Zeaxanthinmentioning

confidence: 99%

Carotenoid Production from Microalgae: Biosynthesis, Salinity Responses and Novel Biotechnologies

et al. 2021

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Microalgae are excellent biological factories for high-value products and contain biofunctional carotenoids. Carotenoids are a group of natural pigments with high value in social production and human health. They have been widely used in food additives, pharmaceutics and cosmetics. Astaxanthin, β-carotene and lutein are currently the three carotenoids with the largest market share. Meanwhile, other less studied pigments, such as fucoxanthin and zeaxanthin, also exist in microalgae and have great biofunctional potentials. Since carotenoid accumulation is related to environments and cultivation of microalgae in seawater is a difficult biotechnological problem, the contributions of salt stress on carotenoid accumulation in microalgae need to be revealed for large-scale production. This review comprehensively summarizes the carotenoid biosynthesis and salinity responses of microalgae. Applications of salt stress to induce carotenoid accumulation, potentials of the Internet of Things in microalgae cultivation and future aspects for seawater cultivation are also discussed. As the global market share of carotenoids is still ascending, large-scale, economical and intelligent biotechnologies for carotenoid production play vital roles in the future microalgal economy.

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Sources, health benefits, and biological properties of zeaxanthin

Cited by 48 publications

References 155 publications

Mechanisms, Anti-Quorum-Sensing Actions, and Clinical Trials of Medicinal Plant Bioactive Compounds against Bacteria: A Comprehensive Review

Mechanisms, Anti-Quorum-Sensing Actions, and Clinical Trials of Medicinal Plant Bioactive Compounds against Bacteria: A Comprehensive Review

Assessment of the Bioaccessibility of Carotenoids in Goji Berry (Lycium barbarum L.) in Three Forms: In Vitro Digestion Model and Metabolomics Approach

Carotenoid Production from Microalgae: Biosynthesis, Salinity Responses and Novel Biotechnologies

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