Sources, Characteristics, and Therapeutic Applications of Mesenchymal Cells in Tissue Engineering

Gonzalez-Vilchis, Rosa Angelica; Piedra-Ramirez, Angelica; Patiño‐Morales, Carlos César; Sánchez‐Gómez, Concepción; Beltran-Vargas, Nohra E

doi:10.1007/s13770-021-00417-1

Cited by 23 publications

(10 citation statements)

References 200 publications

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“…These results suggest that MSCs are excellent for clinical use due to having a wide range of applications and sufficient supply, in addition to fewer safety-related and ethical issues. Allogenic MSCs are expected to have a wide range of therapeutic effects, and clinical trials are currently underway in various diseases, such as osteochondral disease, decompensated liver cirrhosis, systemic erythematosus, acute transplant-to-host disease, Crohn’s disease, myocardial infarction, cerebral infarction, and Parkinson’s disease [ 180 , 181 , 182 , 183 , 184 , 185 , 186 , 187 , 188 , 189 , 190 , 191 , 192 ]. In safety evaluation studies, mild-to-moderate abnormalities, such as fever, chills, headache, fatigue, increased anxiety, redness of administered skin, edema, weight loss, cold, and cough, were frequently observed, but no serious acute adverse events were reported even in elderly patients.…”

Section: Mesenchymal Stem Cells (Mscs) For Regenerationmentioning

confidence: 99%

Therapeutic Strategy of Mesenchymal-Stem-Cell-Derived Extracellular Vesicles as Regenerative Medicine

Matsuzaka

Yashiro

2022

IJMS

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Extracellular vesicles (EVs) are lipid bilayer membrane particles that play critical roles in intracellular communication through EV-encapsulated informative content, including proteins, lipids, and nucleic acids. Mesenchymal stem cells (MSCs) are pluripotent stem cells with self-renewal ability derived from bone marrow, fat, umbilical cord, menstruation blood, pulp, etc., which they use to induce tissue regeneration by their direct recruitment into injured tissues, including the heart, liver, lung, kidney, etc., or secreting factors, such as vascular endothelial growth factor or insulin-like growth factor. Recently, MSC-derived EVs have been shown to have regenerative effects against various diseases, partially due to the post-transcriptional regulation of target genes by miRNAs. Furthermore, EVs have garnered attention as novel drug delivery systems, because they can specially encapsulate various target molecules. In this review, we summarize the regenerative effects and molecular mechanisms of MSC-derived EVs.

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Section: Mesenchymal Stem Cells (Mscs) For Regenerationmentioning

confidence: 99%

Therapeutic Strategy of Mesenchymal-Stem-Cell-Derived Extracellular Vesicles as Regenerative Medicine

Matsuzaka

Yashiro

2022

IJMS

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“…BM-MSCs have low proliferative capacity (Dominici et al, 2006;Kern et al, 2006;Maqsood et al, 2020;Gonzalez-Vilchis et al, 2022 MSCs,BM-MSCs and UC-MSCs commonly expressed specific surface markers, but other antigens were differently expressed (Dominici et al, 2006). AD-MSCs typically expressed CD34 differentiation cluster, while UC-MSCs and BM-MSCs showed the negative expression for CD34 (Gonzalez-Vilchis et al, 2022).…”

Section: Adipocytesmentioning

confidence: 99%

Advances in mesenchymal stromal cell therapy for acute lung injury/acute respiratory distress syndrome

Liu

Xiao

Xie

2022

Front. Cell Dev. Biol.

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Acute lung injury (ALI)/acute respiratory distress syndrome (ARDS) develops rapidly and has high mortality. ALI/ARDS is mainly manifested as acute or progressive hypoxic respiratory failure. At present, there is no effective clinical intervention for the treatment of ALI/ARDS. Mesenchymal stromal cells (MSCs) show promise for ALI/ARDS treatment due to their biological characteristics, easy cultivation, low immunogenicity, and abundant sources. The therapeutic mechanisms of MSCs in diseases are related to their homing capability, multidirectional differentiation, anti-inflammatory effect, paracrine signaling, macrophage polarization, the polarization of the MSCs themselves, and MSCs-derived exosomes. In this review, we discuss the pathogenesis of ALI/ARDS along with the biological characteristics and mechanisms of MSCs in the treatment of ALI/ARDS.

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“…Specifically, the acid-etching process was isolated in the study group to investigate its effects on implant surface morphology at the micro-and nanoscale levels. hBM-MSCs are gaining increasing importance in the field of bone regenerative medicine due to their fundamental role in the bone healing and regeneration processes as precursors of osteoblasts [27][28][29]. To highlight the potential importance of micro-and nanofeatures in the overall performance of the new PTC device, we also examined the response of hBM-MSCs to these surfaces in terms of cell viability and expression of early osteogenic differentiation markers.…”

Section: Introductionmentioning

confidence: 99%

Early Osteogenic Marker Expression in hMSCs Cultured onto Acid Etching-Derived Micro- and Nanotopography 3D-Printed Titanium Surfaces

Bloise

Waldorff

Montagna

et al. 2022

IJMS

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Polyetheretherketone (PEEK) titanium composite (PTC) is a novel interbody fusion device that combines a PEEK core with titanium alloy (Ti6Al4V) endplates. The present study aimed to investigate the in vitro biological reactivity of human bone-marrow-derived mesenchymal stem cells (hBM-MSCs) to micro- and nanotopographies produced by an acid-etching process on the surface of 3D-printed PTC endplates. Optical profilometer and scanning electron microscopy were used to assess the surface roughness and identify the nano-features of etched or unetched PTC endplates, respectively. The viability, morphology and the expression of specific osteogenic markers were examined after 7 days of culture in the seeded cells. Haralick texture analysis was carried out on the unseeded endplates to correlate surface texture features to the biological data. The acid-etching process modified the surface roughness of the 3D-printed PTC endplates, creating micro- and nano-scale structures that significantly contributed to sustaining the viability of hBM-MSCs and triggering the expression of early osteogenic markers, such as alkaline phosphatase activity and bone-ECM protein production. Finally, the topography of 3D-printed PTC endplates influenced Haralick’s features, which in turn correlated with the expression of two osteogenic markers, osteopontin and osteocalcin. Overall, these data demonstrate that the acid-etching process of PTC endplates created a favourable environment for osteogenic differentiation of hBM-MSCs and may potentially have clinical benefit.

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Sources, Characteristics, and Therapeutic Applications of Mesenchymal Cells in Tissue Engineering

Cited by 23 publications

References 200 publications

Therapeutic Strategy of Mesenchymal-Stem-Cell-Derived Extracellular Vesicles as Regenerative Medicine

Therapeutic Strategy of Mesenchymal-Stem-Cell-Derived Extracellular Vesicles as Regenerative Medicine

Advances in mesenchymal stromal cell therapy for acute lung injury/acute respiratory distress syndrome

Early Osteogenic Marker Expression in hMSCs Cultured onto Acid Etching-Derived Micro- and Nanotopography 3D-Printed Titanium Surfaces

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