Source localization of the N400 response in a sentence-reading paradigm using evoked magnetic fields and magnetic resonance imaging

Simos, Panagiotis G.; Basile, Luis; Papanicolaou, Andrew C.

doi:10.1016/s0006-8993(97)00349-1

Cited by 139 publications

(74 citation statements)

References 46 publications

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“…The source location of the N400m-like response being slightly posterior to the N1m source agrees with recent MEG results of the N400m in sentence contexts originating in the left posterior-temporal regions [9,13,14,27] in the vicinity of the N1m source [15]. Further, the PMNm source location anterior to the N400m-like response and the N1m implies that the PMNm originates, at least in the left hemisphere, from the anterior parts of the temporal cortex.…”

Section: Discussionsupporting

confidence: 90%

Activation in the anterior left auditory cortex associated with phonological analysis of speech input: localization of the phonological mismatch negativity response with MEG

Kujala

Alho

Ilmoniemi

et al. 2004

Cognitive Brain Research

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The spatio-temporal dynamics of cortical activation underlying auditory word recognition, particularly its phonological stage, was studied with whole-head magnetoencephalography (MEG). Subjects performed a visuo-auditory priming task known to evoke the phonological mismatch negativity (PMN) response that is elicited by violations of phonological expectancies. Words and non-words were presented in separate conditions. In each of the 318 trials, the subjects first saw a word/non-word (e.g., 'cat') that was soon followed by a prime letter (e.g., 'h'). Their task was to replace mentally the sound of the first letter of the word/non-word with the prime letter, thus resulting in a new word/non-word (e.g., 'hat'). Finally, an auditory word/nonword either matching or mismatching with the anticipated item was presented. In most subjects, a PMNm followed by a later, N400m-like negativity was obtained in the left hemisphere to the mismatching auditory stimuli. A similar response pattern was obtained in the right hemisphere only in a few subjects. Source localization of the N1m, an index of acoustic analysis, and the PMNm and N400m-like responses was performed using L1 minimum-norm estimation. In the left hemisphere, the PMNm source for the words was significantly more anterior than the source of the N400m-like response; for the non-words, the PMNm source was significantly more anterior than the sources of the N1m and the N400m-like response. These results suggest that the lefthemisphere neuronal networks involved in sub-lexical phonological analysis are at least partly different from those responsible for the earlier (acoustic) and later (whole item) processing of speech input.

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Section: Discussionsupporting

confidence: 90%

Activation in the anterior left auditory cortex associated with phonological analysis of speech input: localization of the phonological mismatch negativity response with MEG

Kujala

Alho

Ilmoniemi

et al. 2004

Cognitive Brain Research

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“…The cortical distribution and timing of these responses were similar to those of the N400m as measured by MEG (Dhond et al, 2001;Halgren et al, 2002;Marinkovic et al, 2003) and intracranial EEG (Smith et al, 1986;Halgren et al, 1994b;Halgren et al, 1994a;Guillem et al, 1995;McCarthy et al, 1995). Other MEG studies utilizing single or a few dipoles have found context sensitive N400-like components at similar latencies localizing within temporal and/or frontal regions (Simos et al, 1997;Helenius et al, 1998Helenius et al, , 1999Penney et al, 2003;Puregger et al, 2003;Pylkkanen and Marantz, 2003). At this time, there was also strong bilateral recruitment of cingulate cortex, which may play a role in attention and working memory as well as response choice (Bush et al, 2000;Braver and Barch, 2002;Cabeza et al, 2003;Wang et al, in press).…”

Section: Overall Brain Response Pattern During Word Retrievalsupporting

confidence: 70%

Spatiotemporal brain maps of delayed word repetition and recognition

et al. 2005

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Whole-head magnetoencephalography (MEG) was used to spatiotemporally map the brain response underlying episodic retrieval of words studied a single time following a long delay (~40min.) Recognition following a long delay occurs as a strong, sustained, differential response, within bilateral, ventral and lateral prefrontal cortex, anterior temporal and medial parietal regions from 500ms onward, as well as ventral occipitotemporal regions from ~700ms onward. In comparison with previous tasks using multiple repetitions at short delays, these effects were centered within the same areas (anteroventral temporal and ventral prefrontal), but were shifted to longer latencies (~500ms vs. ~200ms), were less left-lateralized, and appear more in anterolateral prefrontal regions and less in lateral temporal cortex. Furthermore, comparison of correctly classified words with misclassified, novel and repeated words, suggests that these frontotemporal-parietocingulate responses are sensitive to actual as well as perceived repetition. The results also suggest that lateral prefrontal regions may participate more in controlled, effortful retrieval while left ventral frontal and anterior temporal responses may support sustained lexicosemantic processing. Additionally, left ventromedial temporal sites may be relatively more involved in episodic retrieval, while lateral temporal sites may participate more in automatic priming.

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“…In other research, however, nearby regions have been implicated in attention to unexpected stimuli (Corbetta, Kincade, Ollinger, McAvoy, & Shulman, 2000;Mitchell, 2007), including unexpected human actions (Buccino, et al, 2007;Grezes, Frith, & Passingham, 2004;Pelphrey, Morris, & McCarthy, 2004), as well as other inconsistent information (Ferstl, Neumann, Bogler, & von Cramon, 2008;Simos, Basile, & Papanicolaou, 1997;Virtue, Parrish, & Jung-Beeman, 2008). Could the current results be due to differences in attention across the conditions (e.g., attempted / accidental harm / help) of the current study?…”

Section: Reverse Inference and Other Functions Of The Rtpjmentioning

confidence: 98%

Neural evidence for “intuitive prosecution”: The use of mental state information for negative moral verdicts

Young

Scholz

Saxe

2011

Social Neuroscience

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Source localization of the N400 response in a sentence-reading paradigm using evoked magnetic fields and magnetic resonance imaging

Cited by 139 publications

References 46 publications

Activation in the anterior left auditory cortex associated with phonological analysis of speech input: localization of the phonological mismatch negativity response with MEG

Activation in the anterior left auditory cortex associated with phonological analysis of speech input: localization of the phonological mismatch negativity response with MEG

Spatiotemporal brain maps of delayed word repetition and recognition

Neural evidence for “intuitive prosecution”: The use of mental state information for negative moral verdicts

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