Sour Cherries but Not Apples Added to the Regular Diet Decrease Resting and fMLP-Stimulated Chemiluminescence of Fasting Whole Blood in Healthy Subjects

Abstract

The inhibition of resting and agonist-induced LBCL suggests that regular sour cherry consumption may suppress the formation of reactive oxygen species by circulating phagocytes and decrease the risk of systemic imbalance between oxidants and antioxidants. This may be attributed to the anthocyanins in sour cherry and be one of mechanisms of the health-promoting effects of consumption of anthocyanin-rich fruits.

Decreased integrity of exercise-induced plasma cell free nuclear DNA – negative association with the increased oxidants production by circulating phagocytes

“…Moreover, we studied the effect of exercise on LBCL, thus neutrophils and monocytes were not subjected to any process of isolation that could change the cell ability to respond to stimulations with various agonists. Elimination of the risk of cell priming or de-priming during the isolation procedure is the important advantage of this method 21,31 . Such technique allows monitoring of oxidants release by circulating phagocytes under conditions that more closely resemble the in vivo situation than the analysis of isolated cells 31,47 .…”

“…Elimination of the risk of cell priming or de-priming during the isolation procedure is the important advantage of this method 21,31 . Such technique allows monitoring of oxidants release by circulating phagocytes under conditions that more closely resemble the in vivo situation than the analysis of isolated cells 31,47 . Severe exercise resulted in essential increase in plasma pro-inflammatory cytokines, namely IL-6, IL-8, granulocyte colony-stimulating factor (G-CSF), macrophage colony-stimulating factor (M-CSF), and granulocyte macrophage colony stimulating factor (GM-CSF) 48,49 .…”

“…The resting (rLBCL) and fMLP-induced LBCL (fMLP-LBCL) reflecting ROS production by circulating phagocytes were measured according to the method of Kukovetz et al . 21 with some modifications 31 .…”

“…Both rLBCL and fMLP-LBCL were increased in patients suffering from diseases accompanied by systemic inflammatory response such as systemic sclerosis, infective endocarditis and chronic renal failure 27–29 . Moreover, LBCL was attenuated in healthy subjects in response to regular consumption of fruits rich in anti-oxidant and anti-inflammatory polyphenols 30,31 .…”

Anthocyanins: From the Field to the Antioxidants in the Body

“…Another study [117] concluded that the acute consumption of anthocyanin-rich red Vitis labrusca L. grape juices could be related to decreased levels of thiobarbituric acid reactive substances and lipid peroxides in the serum of healthy subjects. It has also been demonstrated that regular (for 30 days) anthocyanin-rich sour cherry consumption could suppress the formation of ROS by circulating phagocytes and decrease the risk of systemic imbalance between oxidants and antioxidants [118]. It is worth noting that a portion (300 g) of blueberries, the dietary source of anthocyanins provided to young volunteers involved in a randomized cross-over study, significantly reduced H 2 O 2 -induced DNA damage in blood mononuclear cells [119].…”