Sound sequence discrimination learning is dependent on cholinergic inputs to the rat auditory cortex

Kudoh, Masaharu; Seki, Kenjiro; Shibuki, Katsuei

doi:10.1016/j.neures.2004.06.007

Cited by 24 publications

(35 citation statements)

References 53 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The discrimination of temporal auditory patterns is impaired by ablation of the AC (Diamond and Neff 1957;Kaas et al 1967;Dewson and Cowey 1969). We have demonstrated that sequence discrimination learning in rats is facilitated by cholinergic inputs to the AC (Kudoh et al 2004).…”

mentioning

confidence: 79%

“…We have reported that sound sequence discrimination learning can be investigated behaviorally in rats (Kudoh et al 2004). Discrimination between sequences of two sounds was tested as shown in Figure 1A,B,C.…”

Section: Attenuation Of Sound Sequence Discrimination Learning By Elementioning

confidence: 99%

“…2E). The depths of 70% and 30% were chosen because the test performance at these depths showed a similar learning curve to that of the sound sequence discrimination (Kudoh et al 2004). The AC lesions attenuated discrimination learning between AMs of 70% and 30% modulation depths (P < 0.05, repeated measures ANOVA) (Fig.…”

Section: Attenuation Of Sound Sequence Discrimination Learning By Elementioning

confidence: 99%

“…Neuronal plasticity in the AC is induced by sound stimulus paired with electrical stimulation in the ventral tegmental area (Bao et al 2001(Bao et al , 2003. In our previous behavioral study, water-deprived rats were trained to discriminate between sound sequences using a reward of water (Kudoh et al 2004). The mechanism of sound sequence discrimination learning has been attributed to neuronal plasticity in the AC (Seki et al 2001;Kudoh et al 2004).…”

mentioning

confidence: 99%

“…In our previous behavioral study, water-deprived rats were trained to discriminate between sound sequences using a reward of water (Kudoh et al 2004). The mechanism of sound sequence discrimination learning has been attributed to neuronal plasticity in the AC (Seki et al 2001;Kudoh et al 2004). Therefore, it is very likely that the dopaminergic fibers projecting into various brain areas including the AC play an important role in sound sequence discrimination learning.…”

mentioning

confidence: 99%

See 4 more Smart Citations

Sound sequence discrimination learning motivated by reward requires dopaminergic D2 receptor activation in the rat auditory cortex

Kudoh¹,

Shibuki²

2006

Learn. Mem.

Self Cite

View full text Add to dashboard Cite

We have previously reported that sound sequence discrimination learning requires cholinergic inputs to the auditory cortex (AC) in rats. In that study, reward was used for motivating discrimination behavior in rats. Therefore, dopaminergic inputs mediating reward signals may have an important role in the learning. We tested the possibility in the present study. Rats were trained to discriminate sequences of two sound components, and licking behavior in response to one of the two sequences was rewarded with water. To identify the dopaminergic inputs responsible for the learning, dopaminergic afferents to the AC were lesioned with local injection of 6-hydroxydopamine (6-OHDA). The injection attenuated sound sequence discrimination learning, while it had no effect on discrimination between the sound components of the sequence stimuli. Local injection of 6-OHDA into the nucleus accumbens attenuated sound discrimination learning. However, not only discrimination learning of sound sequence but also that of the sound components were impaired. SCH23390 (0.2 mg/kg, i.p.), a D1 receptor antagonist, had no effect on sound sequence discrimination learning, while it attenuated the licking behavior to unfamiliar stimuli. Haloperidol (0.5 mg/kg, i.p.), a D2 family antagonist, attenuated sound sequence discrimination learning, while it had no clear suppressive effect on discrimination of two different sound components and licking. These results suggest that D2 family receptors activated by dopaminergic inputs to the AC are required for sound sequence discrimination learning.

show abstract

mentioning

confidence: 79%

Section: Attenuation Of Sound Sequence Discrimination Learning By Elementioning

confidence: 99%

Section: Attenuation Of Sound Sequence Discrimination Learning By Elementioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

See 3 more Smart Citations

Sound sequence discrimination learning motivated by reward requires dopaminergic D2 receptor activation in the rat auditory cortex

Kudoh¹,

Shibuki²

2006

Learn. Mem.

Self Cite

View full text Add to dashboard Cite

show abstract

Attention and Dynamic, Task-Related Receptive Field Plasticity in Adult Auditory Cortex

Fritz

David

Shamma

2012

Neural Correlates of Auditory Cognition

View full text Add to dashboard Cite

Localization of pre- and postsynaptic cholinergic markers in rodent forebrain: A brief history and comparison of rat and mouse

Zee

Keijser

2011

Behavioural Brain Research

View full text Add to dashboard Cite

Sound sequence discrimination learning is dependent on cholinergic inputs to the rat auditory cortex

Cited by 24 publications

References 53 publications

Sound sequence discrimination learning motivated by reward requires dopaminergic D2 receptor activation in the rat auditory cortex

Sound sequence discrimination learning motivated by reward requires dopaminergic D2 receptor activation in the rat auditory cortex

Attention and Dynamic, Task-Related Receptive Field Plasticity in Adult Auditory Cortex

Localization of pre- and postsynaptic cholinergic markers in rodent forebrain: A brief history and comparison of rat and mouse

Contact Info

Product

Resources

About