Sound-precipitated convulsions: 1947-1954.

Bevan, William

doi:10.1037/h0044568

Cited by 64 publications

(10 citation statements)

References 80 publications

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“…This stage is rapidly followed by violent, wild, uncontrolled running and a convulsion involving tonic and clonic episodes. Animals were arbitarily divided into sensitive strains which generally died, or resistant strains which rapidly recovered (Bevan, 1955).…”

Section: ( I ) M I C E ( a ) Audiogenic Seizuresmentioning

confidence: 99%

Sound and Its Significance for Laboratory Animals

Gamble

1982

Biological Reviews

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Summary 1. Several methods of varying accuracy have been used to assess what sounds small laboratory animals such as rodents are capable of hearing. Most rodents can detect sounds from 1000 Hz (the frequency of the Greenwich Time Signal) up to 100000 Hz, depending on the strain, with usually one or more commonly two peaks of sensitivity within this range. Dogs can detect sound most easily from 500 Hz to 55000 Hz, depending on the breed. 2. Rodents also produce sound signals as a behavioural response and for communication in a variety of situations. Ultrasonic calls in the range 22000–70000 Hz are the main communicating pathway during aggressive encounters, mating, and mothering. Similar calls have also been recorded from isolated animals associated with inactivity, rest and possibly even sleep. 3. Very loud sounds cause seizures in rats and mice, or can make them more susceptible to other sounds later in life. This effect is possible even when animals are fully anaesthetized. Sound tends to startle and reduce activity in several species of animal. Even offspring of mice that have been sound‐stressed exhibit abnormal behaviour patterns. Sounds also elicit various responses in rats from increasing aggression to making them more tolerant to electric shocks. 4. Levels of sound above 100 dB are teratogenic in several species of animals and several hormonal, haematological and reproductive parameters are disturbed by sounds above 80 dB. When rats are chemically deafened the disturbance to their fertility disappears. Lipid metabolism is disrupted in rats when exposed to over 95 dB of sounds, leading to increases in plasma triglycerides. Atherosclerosis can be produced in rabbits by similar levels of sound. 5. It has also been shown in guinea pigs and cats that hearing damage is governed by the duration as well as the intensity of the sound and is irreversible. Work on chinchillas hs demonstrated that sounds above 95 dB lead to this injury, but that sounds of 80 dB have no permanent effect on hearing sensitivity.

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Section: ( I ) M I C E ( a ) Audiogenic Seizuresmentioning

confidence: 99%

Sound and Its Significance for Laboratory Animals

Gamble

1982

Biological Reviews

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“…Pretest exposure to sound enhances or reduces susceptibility depending upon the temporal parameters of the treatrnent (Ginsburg, 1963;Fuller & Wimer, 1966). "The classical priming method of physiology has shown the number of animals convulsing varies the duration of the conditioning stimulus and the condition-test stimulation interval" according to Bevan (1955). Generally, both the duration of the conditioning stimulus and conditioning-test interval have been short, being only a few seconds (Fuller 8c Smith, 1953;Bevan, 1955).…”

Section: Iturrianmentioning

confidence: 99%

“…"The classical priming method of physiology has shown the number of animals convulsing varies the duration of the conditioning stimulus and the condition-test stimulation interval" according to Bevan (1955). Generally, both the duration of the conditioning stimulus and conditioning-test interval have been short, being only a few seconds (Fuller 8c Smith, 1953;Bevan, 1955). However, by spacing tests at a predetermined interval of days, seizure incidence Developmental PsychoDiology, l(4): 230-235 (1968) among mice of certain strains can be increased (Henry, 1967;Iturrian & Fink, 1967).…”

Section: Iturrianmentioning

confidence: 99%

Effect of age and condition‐test interval (days) on an audio‐conditioned convulsive response in CF#1 mice

Iturrian

Fink

1968

Developmental Psychobiology

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T h e initial exposure to sound provokes seizures in genetically audio-sensitive mice. I n a stock (e.g., CF# 1) generally considered audio-resistant, repeated sound exposure will under certain conditions induce seizure susceptibility. Susceptibilty is dramatically influenced by age and interval (days) between initial and subsequent exposure to sound. Previous auditory stimulation is absolutely essential for the genesis of convulsions. Selection of age and condition-test interval produced seizures of predictable incidence and severity. Incidence in 12-or 45-day-old mice was about 5% at any interval. However, 18-day-old mice subjected to brief auditory stimulation (60 sec at 95 db) and tested at intervals of 1, 2, 3, 4, or 5 days resulted in a high incidence of convulsions. Clonic-tonic convulsions characterized the seizures at the 2-or 3-day interval; but at 5 days only clonus was seen. Without further sound stimulation mice show a transitory audio-sensitivity lasting about 5 days. Sound-induced convulsions or repeated auditory stimulation prolong sensitivity. Important characteristics of the genetically controlled audiogenic crisis in contrast with other sound-induced convulsions include: the essential prior auditory stimulation, the brief duration of susceptibility, and the adaptation to chronic noise. age-dependent seizure susceptibility sound induced convulsions audiogenic seizures neuro-ontogenic critical period neuro-behavioral development

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“…Neuronal pathways involved in audiogenic seizures are located in the brain stem [18][19][20], and the cerebral cortex is also involved in the seizures [21,22]. Rodent strains such as DBA/2J mice are genetically susceptible to audiogenic seizures [23], and these have been among the most intensively studied phenotypes in behavioral genetics [17,24]. In the present study, we visualized epileptic foci in the cortex of DBA/2J mice using transcranial flavoprotein fluorescence imaging.…”

Section: Introductionmentioning

confidence: 98%

Transcranial imaging of audiogenic epileptic foci in the cortex of DBA/2J mice

Takao¹,

Murakami²,

Fukuda³

et al. 2006

NeuroReport

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Exposure to intense sound stimuli induces audiogenic seizures in DBA/2J mice. We investigated cortical activities during sound stimulation using flavoprotein fluorescence imaging. Most DBA/2J mice had seizures during intense sound stimulation, with more than half surviving after seizures. Surviving mice were anesthetized with urethane (1.6 g/kg, intraperitoneal), and the skull was exposed and then covered with clear resin. More than 3 days after surgery, the mice were lightly anesthetized with urethane (0.8 g/kg) and cortical activities during intense sound stimulation were visualized. Focal responses appeared near the somatosensory cortex together with spike activities localized in the response area. These findings indicate that epileptic foci of audiogenic seizure are formed in the cortex of DBA/2J mice.

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Sound-precipitated convulsions: 1947-1954.

Cited by 64 publications

References 80 publications

Sound and Its Significance for Laboratory Animals

Sound and Its Significance for Laboratory Animals

Effect of age and condition‐test interval (days) on an audio‐conditioned convulsive response in CF#1 mice

Transcranial imaging of audiogenic epileptic foci in the cortex of DBA/2J mice

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