Sound-induced Activation of Auditory Cortices in Cochlear Implant Users with Post- and Prelingual Deafness Demonstrated by Positron Emission Tomography

Naito, Yasushi; Hirano, Shigeru; Honjo, Iwao; Okazawa, Hidehiko; Ishizu, Koji; Takahashi, Haruo; Fujiki, Nobuya; Shiomi, Yosaku; Yonekura, Yoshiharu; Konishi, Junji

doi:10.3109/00016489709113426

Cited by 72 publications

(41 citation statements)

References 11 publications

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“…The recruitment of auditory association areas by other cognitive processes, in particular by non-auditory language, is probably accompanied by an irreversible depression of connections from the primary auditory region. This idea is supported by a reduction of activation in secondary auditory and association language areas in response to speech in prelingual CI patients compared to normal and postlingual CI patients [Naito et al, 1997].…”

Section: Plasticity Associated With Prelingual Deafnesssupporting

confidence: 58%

“…4). Several studies had previously shown that Wernicke's area was activated in post-and even prelingual CI patients in response to speech [Okazawa et al, 1996;Naito et al, 1997]. However, the specificity of the response was not clear.…”

Section: Reorganisation Of the Speech Perception Systemmentioning

confidence: 96%

“…Thus, cross-modal competition remains confined to secondary auditory and association areas and spares primary auditory regions [Nishimura et al, 2000]. The selective sparing of primary regions from takeover by other modalities can be deduced from the observation that the primary auditory cortex responds to noise and speech in prelingual CI adults [Herzog et al, 1991;Naito et al, 1997;Truy et al, 1995]. Persisting susceptibility of primary regions to potential auditory inputs allows prelingual patients to detect stimulation coming from an implant, but is insufficient for speech comprehension.…”

Section: Plasticity Associated With Prelingual Deafnessmentioning

confidence: 99%

“…In contrast to prelingual CI patients, those patients who lost hearing after the critical stages of language development show soundinduced responses after implantation that often extend to secondary auditory and association cortices, even very soon after implantation, i.e. before significant language rehabilitation [Naito et al, 1997;Okazawa et al, 1996].…”

Section: Plasticity Associated With Postlingual Deafnessmentioning

confidence: 99%

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Imaging Plasticity in Cochlear Implant Patients

Giraud

Truy

Frackowiak³

2001

Audiol Neurotol

103

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Auditory re-afferentation by cochlear implants (CI) offers a unique opportunity to study directly from within the auditory modality plastic changes taking place at organisational levels up to the supra- or polymodal level. These plastic changes resulting from deafness and chronic electrical stimulation can be studied using modern neuroimaging techniques. In this paper, we review the available techniques and the experimental approaches to human studies of plasticity, we discuss the different forms of plasticity that are associated with cochlear implantation and we point to the interest of imaging studies for providing a prognosis of functional outcome after implantation.

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Section: Plasticity Associated With Prelingual Deafnesssupporting

confidence: 58%

Section: Reorganisation Of the Speech Perception Systemmentioning

confidence: 96%

Section: Plasticity Associated With Prelingual Deafnessmentioning

confidence: 99%

Section: Plasticity Associated With Postlingual Deafnessmentioning

confidence: 99%

See 2 more Smart Citations

Imaging Plasticity in Cochlear Implant Patients

Giraud

Truy

Frackowiak³

2001

Audiol Neurotol

103

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“…bilateral (contralateral 1 ipsilateral), broad but weaker activation than that caused by speech stimuli [Naito et al, 1995]. Moreover, the significant activation of the primary cortex was not consistently shown (only small to no statistical significance) in previous PET studies with whitenoise stimuli [Okazawa et al, 1996;Naito et al, 1997Naito et al, , 2000. Lateralization differences of cortical activation according to gender have been controversial, although a recent large-scale report denied intersexual differences [Frost et al, 1999].…”

Section: Differences In Cortical Activation Between Normal Subjects Amentioning

confidence: 91%

Cortical Activation Shortly after Cochlear Implantation

Ito¹,

Momose

Oku

et al. 2004

Audiol Neurotol

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We evaluated the cortical activations in postlingually deaf cochlear implant (CI) users in the early period (0–2 months) of CI usage. The subjects were 8 early CI users and 8 normal subjects. With tone burst stimuli (1 kHz) delivered to the right side, strong and broad activation of the ipsilateral (right) primary auditory cortex with 2 peaks and weaker activation of the contralateral (left) temporal lobe were observed in early CI users, in a clear contrast with the normal subjects in whom activation was observed in a small area of the contralateral (left) primary cortex. With word stimuli, activation of the superior frontomedian cortex presumably including the supplementary motor area and the neighboring cingulate gyri was observed in early CI users, which was absent in normal subjects. The activation in the immediate association cortices near the primary area was lower in early CI users, while the periphery of the association cortex seemed to be more mobilized.

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An Animal Model for Cochlear Implants

Kretzmer¹,

Meltzer²,

Haenggeli³

et al. 2004

Arch Otolaryngol Head Neck Surg

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To test the feasibility of using the deaf white cat model of early-onset deafness. We studied the neuronal effects of prosthetic intervention with a clinical, "offthe-shelf" multichannel cochlear implant. Methods: We placed cochlear implants in 5 deaf white kittens at age 12 and 24 weeks. The devices were activated and stimulated in the laboratory using a clinical speech processor programmed with a high-resolution continuous interleaved sampling (CIS) strategy for 8 to 24 weeks. Stimulus parameters were guided by electrically evoked brainstem responses and intracochlear-evoked potentials. Kittens were assessed with respect to their tolerance and general behavior in response to speech, music, and environmental sounds. Results: Surgical complications were minimal, and kittens tolerated the experimental procedures well. Subjects were able to detect and respond to a specific sound played from a computer speaker. Electrophysiologic responses were reliably attainable and showed consistency with observed behavioral responses to sound. This experimental paradigm, using clinical devices, can be used in a practical research setting in cats. Conclusions: Deafness and other variations in neural activity result in many distinct changes to the central auditory pathways. Animal models will facilitate assessment of the reversibility of deafness-associated changes at the level of the neuron and its connections. Our observations of the feasibility of using clinical devices in animal models will enable us to simulate clinical conditions in addressing questions about the effects of "replacement" activity on the structure and function within the central auditory pathways in deafness.

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Sound-induced Activation of Auditory Cortices in Cochlear Implant Users with Post- and Prelingual Deafness Demonstrated by Positron Emission Tomography

Cited by 72 publications

References 11 publications

Imaging Plasticity in Cochlear Implant Patients

Imaging Plasticity in Cochlear Implant Patients

Cortical Activation Shortly after Cochlear Implantation

An Animal Model for Cochlear Implants

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