SOS genes are rapidly induced while translesion synthesis polymerase activity is temporally regulated
Olaug Elisabeth Torheim Bergum,
Amanda Holstad Singleton,
Lisa Marie Røst
et al.
Abstract:The DNA damage inducible SOS response in bacteria serves to increase survival of the species at the cost of mutagenesis. The SOS response first initiates error-free repair followed by error-prone repair. Here, we have employed a multi-omics approach to elucidate the temporal coordination of the SOS response. Escherichia coli was grown in batch cultivation in bioreactors to ensure highly controlled conditions, and a low dose of the antibiotic ciprofloxacin was used to activate the SOS response while avoiding ex… Show more
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