Sorting Nexin 11 Regulates Lysosomal Degradation of Plasma Membrane <scp>TRPV3</scp>

Li, Caiyue; Ma, Wenbo; Yin, Shikui; Liang, Xin; Shu, Xiaodong; Pei, Duanqing; Egan, Terrance M.; Huang, Jufang; Pan, Aihua; Li, Zhiyuan

doi:10.1111/tra.12379

Cited by 18 publications

(16 citation statements)

References 56 publications

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“…Moreover, the abundance of this pathway increased at 35 °C and 40 °C, indicating that the membrane transport metabolism will be enhanced at high temperature. A previous study revealed that there was an important mechanism responsible for temperature sensing in organisms that controls the vesicular transportation of temperature sensory receptors to adjust the transduction of temperature information, which may be an important means of adapting to the variations in environmental temperature [ 67 ]. Overall, the proportion associated with metabolism was highest, and the abundances of other functional pathways varied with temperature, despite being a few differences among some functional pathways.…”

Section: Discussionmentioning

confidence: 99%

Influence of Temperature on the Bacterial Community in Substrate and Extracellular Enzyme Activity ofAuricularia cornea

Zhang

Miao

et al. 2018

Mycobiology

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Temperature is an important environmental factor that can greatly influence the cultivation of Auricularia cornea. In this study, lignin peroxidase, laccase, manganese peroxidase, and cellulose in A. cornea fruiting bodies were tested under five different temperatures (20 °C, 25 °C, 30 °C, 35 °C, and 40 °C) in three different culture periods (10 days, 20 days and 30 days). In addition, the V4 region of bacterial 16S rRNA genes in the substrate of A. cornea cultivated for 30 days at different temperatures were sequenced using next-generation sequencing technology to explore the structure and diversity of bacterial communities in the substrate. Temperature and culture days had a significant effect on the activities of the four enzymes, and changes in activity were not synchronized with changes in temperature and culture days. Overall, we obtained 487,694 sequences from 15 samples and assigned them to 16 bacterial phyla. Bacterial community composition and structure in the substrate changed when the temperature was above 35 °C. The relative abundances of some bacteria were significantly affected by temperature. A total of 35 genera at five temperatures in the substrate were correlated, and 41 functional pathways were predicted in the study. Bacterial genes associated with the membrane transport pathway had the highest average abundance (16.16%), and this increased at 35 °C and 40 °C. Generally, different temperatures had impacts on the physiological activity of A. cornea and the bacterial community in the substrate; therefore, the data presented herein should facilitate cultivation of A. cornea.

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Section: Discussionmentioning

confidence: 99%

Influence of Temperature on the Bacterial Community in Substrate and Extracellular Enzyme Activity ofAuricularia cornea

Zhang

Miao

et al. 2018

Mycobiology

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“…For example, a report suggest that TRPV3 interacts with Nexin 11, a lysosomal protein. 35 TRPML members belong to TRP superfamily are also present in the lysosome and late endosomes; and defects in these TRPMLs also result in lysosomal storage disorders leading to impaired trafficking of lipids and proteins. 36 Similarly, using patch clamp method, presence of TRPV2 in the endosome has also been confirmed.…”

Section: Discussionmentioning

confidence: 99%

TRPV3 mutants causing Olmsted Syndrome induce impaired cell adhesion and nonfunctional lysosomes

Yadav

Goswami

2017

Channels

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TRPV3 is a non-selective cationic channel and is important for several physiological functions. It can be activated by physiological temperature and selective endogenous and exogenous compounds. TRPV3 is one of the key ion channel involved in Ca 2C -signaling in keratinocyte and thus involved in skin-related functions. Recently, naturally occurring mutations in TRPV3, namely G573A, G573S, G573C and W692G have been detected which are linked with the development of pathophysiological conditions such as Olmsted Syndrome (OS) and other skin disorders. Our qualitative and quantitative data suggests that these naturally occurring TRPV3 mutants are mainly restricted in the ER. Expression of OS-mutants cause impaired vesicular trafficking resulting reduced surface localization of these mutants and other membrane proteins too. OS-mutants also cause reduced cell adhesion, altered distribution and less number of lysosomes. Our data confirms that TRPV3 is a lysosomal protein suggesting that Olmsted Syndrome is a lysosomal disorder. These findings may have a broad implication in the context of keratinocyte functions, skin-degeneration and in skin-cancer.

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“…Little is known about SNX11; it belongs to a family of retrograde transport molecules, 31 and its protein is involved in targeting cell-surface molecules to the lysosome. 32 CBX1 is a member of the highly conserved heterochromatin protein family that binds to histones through methylated lysine residues, mediating gene silencing and alternative splicing. 33,34 It is believed that CBX1 can play an important role in epigenetic regulation and gene expression.…”

Section: Identification Of Expression Quantitative Trait Locimentioning

confidence: 99%

Genome-wide association study and meta-analysis in multiple populations identifies new loci for peanut allergy and establishes C11orf30/EMSY as a genetic risk factor for food allergy

Asai

Eslami

Ginkel

et al. 2018

Journal of Allergy and Clinical Immunology

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Sorting Nexin 11 Regulates Lysosomal Degradation of Plasma Membrane TRPV3

Cited by 18 publications

References 56 publications

Influence of Temperature on the Bacterial Community in Substrate and Extracellular Enzyme Activity ofAuricularia cornea

Influence of Temperature on the Bacterial Community in Substrate and Extracellular Enzyme Activity ofAuricularia cornea

TRPV3 mutants causing Olmsted Syndrome induce impaired cell adhesion and nonfunctional lysosomes

Genome-wide association study and meta-analysis in multiple populations identifies new loci for peanut allergy and establishes C11orf30/EMSY as a genetic risk factor for food allergy

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