Sortilin/Omentin-1 ratio in peripheral artery disease: A cross-sectional study on 295 unselected elderly patients

Giovannini, Silvia; Biscetti, Federico; Brau, Fabrizio; Biscotti, Lorenzo; Santoliquido, Angelo; Pitocco, Dario; Bernabei, Roberto; Flex, Andrea

doi:10.1016/j.mad.2022.111677

Cited by 3 publications

(1 citation statement)

References 21 publications

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“…Circulating Sortilin levels have been found to be associated with a higher risk of arteriosclerosis, major adverse cardiac and cerebrovascular events (MACCE), coronary heart disease, and peripheral arterial disease (PAD) [39,40,41,42 ▪ ,43–50].…”

Section: Sortilin and Hypertensionmentioning

confidence: 99%

Sortilin and hypertension

Avvisato

Jankauskas

Varzideh

et al. 2022

Current Opinion in Nephrology &Amp; Hypertension

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Purpose of reviewThe current review aims to present the latest scientific updates on the role of Sortilin in the pathophysiology of hypertension. Recent findingsThe main focus of this systematic overview is on the functional contribution of Sortilin to the pathogenesis of hypertension. Sortilin is a glycoprotein mostly known for its actions as a trafficking molecule directing proteins to specific secretory or endocytic compartments of the cell. Emerging evidence indicates that Sortilin is associated with pathological conditions, including inflammation, arteriosclerosis, dyslipidemia, insulin resistance, and vascular calcification. Most recently, Sortilin has been shown to finely control endothelial function and to drive hypertension by modulating sphingolipid/ceramide homeostasis and by triggering oxidative stress.

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Section: Sortilin and Hypertensionmentioning

confidence: 99%