Sorption/release of diclofenac sodium in/from free‐standing poly(acrylic acid)/poly(ethyleneimine) multilayer films

Abstract

Polyelectrolyte multilayer films deposited onto various substrates have been used extensively as drug delivery systems. However, little attention has been paid to the release of drugs from free‐standing polymeric films. Herein, we report the construction of thermal crosslinked free‐standing poly(acrylic acid) (PAA)/branched poly(ethyleneimine) (PEI) multilayer films composed of 25 double layers [(PAA/PEI)25] and their use in sorption/release of diclofenac sodium (DS). The (PAA/PEI)25 multilayer films were characterized by scanning electron microscopy, potentiometric titrations and Fourier transform infrared spectroscopy, while the sorption/release of DS was monitored by UV–Vis spectroscopy. The DS sorption equilibrium data were fitted with five isotherm models (Langmuir, Freundlich, Sips, Dubinin–Radushkevich, and Temkin). The maximum equilibrium sorption capacity, qm, given by the Langmuir model was 32.42 mg DS/g. The Korsmeyer–Peppas semiempirical equation showed that the release of DS from the free‐standing (PAA/PEI)25 films proceeded by pseudo‐Fickian diffusion, irrespective of the releasing media. © 2016 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2016, 133, 43752.

Synthesis of a Polyacrylic‐Grafted, Multiwalled Carbon Nanotube‐Loaded Gum Ghatti Hydrogel for Diclofenac Removal

“…2. The adsorbents montmorillonite [66], AC/K 2 CO 3 [67], biochar [68], AC/olive stone [8], PAA/PEI25 [69], HXL poly(AN-co-EGDMA-co-VBC) [70], chitosan/magnetic composite [14] showed lower adsorption capacity than GG-g-PAA/O-MWCNTs, while only SA/CNC/PVA)@PEI [33] showed higher adsorption capacity than that in this work.…”

Efficient adsorptive removal of diclofenac sodium by acidified MIL101(Cr): optimizing the content of phosphotungstic acid (PTA), Flow loop thin film slurry flat plate reactor, Kinetic, thermodynamic and recycling studies

“…Adsorption Capacity (mg/g) Reference Activated Carbon -83 [42] ZIF-8 12 hr 100 [42] UIO-66 1 hr 189 [18] 18%SO3H-UIO-66 1 hr 283 [18] Fe3O4@SiO2/SiHTCC 5 hr 240.4 [43] (PAA/PEI)25 2 hr 32.42 [44] UIO-66-NH2 (25) 6.5 hr 357 [6] UIO-66-NH2 (90) 6.5 hr 555 [6] 12%PTA@MIL101(Cr) 2 hr 413.22 This Work…”

Synthesis of Thiourea-Graft-Polyethyleneimine and Its Performance in Flocculation of Some Inorganic Particles

“…Polyethyleneimine (PEI) is a stimuli-responsive synthetic polycation, possessing the highest content of amino groups per macromolecular chain (one amino group at each two methylene units), commercially available in a large variety of molar masses and chain structures (linear, branched, or hyperbranched). Because of these outstanding characteristics, PEI has become interesting for various potential uses, either as it is, or as a constituent in multicomponent materials (hydrogels, , composite nanoparticles, layer-by-layer thin films, , etc.). Examples of recent applications of PEI and PEI-based materials are as sensors for the detection of metal ions, , as drug delivery systems, , as antibacterial coatings, , or as catalysts .…”

“…Because of these outstanding characteristics, PEI has become interesting for various potential uses, either as it is, or as a constituent in multicomponent materials (hydrogels, , composite nanoparticles, layer-by-layer thin films, , etc.). Examples of recent applications of PEI and PEI-based materials are as sensors for the detection of metal ions, , as drug delivery systems, , as antibacterial coatings, , or as catalysts . However, the most important application of PEI is as gene delivery vector, where it is considered the golden standard in nonviral gene therapy. , …”