Soroepidemiologia de rotavírus em uma população infantil, Goinia, Goiás, Brasil

Ishak, Ricardo; Linhares, Alexandre da Costa; Gabbay, Yvone Benchimol; Ishak, Marluísa de Oliveira Guimarães; Cardoso, Divina das Dôres de Paula

doi:10.1590/s0036-46651984000500010

Cited by 9 publications

(8 citation statements)

References 18 publications

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“…They observed that children with "short-term" immunity can become susceptible again by loosing antibody and be reinfected once or twice with rotaviruses. The results support and expand the findings of two other serological surveys of bELISA antibody and one of HIA antibody in serum specimens collected from infants and young children in three diffent cities in Brazil [Azeredo et al, 1989;Ishak et al, 1984;Gomes et al, 19831. The antibody patterns seen in the city of Recife are almost similar to those observed in other developing and developed regions of the world.…”

Section: Discussionsupporting

confidence: 84%

“…In Brazil, few such studies had been carried out and the immune response to these infections has not been completely characterized [Gomes et al, 1983;Ishak et al, 1984;Azeredo et al, 19891. The aims of the present study were to determine the age distribution of rotavirus antibody in newborn to 5-yearold children living in the city of Recife (PE), north eastern region of Brazil, using hemagglutination inhibition and the blocking enzyme immunosorbent assays, and to establish the relationship between the antibody responses and the assays used.…”

Section: Introductionmentioning

confidence: 99%

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Humoral immunity patterns based on antibody reactivity to rotavirus antigens in Brazilian children under 5 years of age

et al. 1996

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The age distribution of antibody to simian rotavirus (SA-11) was studied in serum specimens obtained from 399 children aged to 5 years and living in the city of Recife (PE), located in the north eastern region of Brazil. Sera were examined for group-specific rotavirus antibody using a blocking enzyme immunoassay (bELISA) and a hemagglutination inhibition antibody (HIA) test, and for anti-VP2, anti-VP4, anti-VP6, and anti-VP7 antibodies using an immunoblotting assay (IBA). Antibody prevalence was similar in all bELISA and HIA assays, showing a steep rise in the 6-to 17-month-old age groups. The results indicate early acquisition of antibody to rotavirus. The majority of children aged 2 to 4 years had bELISA (50% to 60%) and HIA (70% to 81%) antibodies. There was an association in prevalence data obtained by HIA and bELISA with immunoblotting (IBA), revealing four serologic profiles. Children with profiles I and II (60%) respectively had HAI and ELISA antibody or HAI antibody alone and all had immunoprotective antibodies to VP4 and/or VP7. These children were regarded as "immune," resembling convalescent patients with a rotavirus infection. Children with profile III (4%) had no HIA antibody and only non-protective anti-VP6 and/or VP7 antibody, and were considered to be "partially immune." Children with profile IV (36%) had no detectable antibody and were classified as "nonimmune." These children should be considered to be susceptible to rotavirus infection, with the risk of developing clinically severe diarrhea.

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Section: Discussionsupporting

confidence: 84%

Section: Introductionmentioning

confidence: 99%

Humoral immunity patterns based on antibody reactivity to rotavirus antigens in Brazilian children under 5 years of age

et al. 1996

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“…In Brazil, the presence of rotavirus has been demonstrated in several states by detecting the virus in feces [12][13][14][15], sewage, and rivers [16], as well as by serological surveys [17,18], thus confirming the intense circulation of this enteropathogen in the country.…”

Section: Rotavirus Infections Discussionmentioning

confidence: 99%

Epidemiological aspects of rotavirus infections in Minas Gerais, Brazil

Silva

Naveca²,

Carvalho³

2001

Braz J Infect Dis

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In order to develop good polices regarding public health measures and vaccine use to prevent rotavirus induced gastroenteritis, the epidemiology of the illness in various regions of Brazil is necessary. Accordingly, this study was to detect the frequency and types of rotavirus in one city in a tropical part of Brazil. This is an epidemiological survey of pediatric gastroenteritis caused by rotavirus conducted in Juiz de Fora, Minas Gerais State, Brazil. We analyzed 656 in-patient (190) and out-patient (466) stool samples from children ages 0 to 5 years during 1998. Rotavirus detection was performed using polyacrylamide gel electrophoresis (PAGE). Rotavirus was isolated from 62/190 stool samples (32.6%) from hospitalized children and 16/466 (3.4%) from outpatients. The overall rotavirus frequency in this population was 11.9%. The highest rotavirus detection was found in hospitalized children ages 6 to 24 months. Rotaviruses were detected from March to September, with a peak incidence in June (33.3%), the coldest and driest month in the region. Electrophoretic analysis identified 10 different profiles, all long and compatible with group A rotavirus, termed L A through LJ. The L B and L D profiles circulated throughout most of the study period. However, in June, when the highest detection rate occurred, the vast majority (92.5%) of the positive samples displayed the L B profile, thus suggesting an outbreak caused by this rotavirus profile. Rotavirus induced gastroenteritis is common in one tropical region of Brazil, it is an important cause of diarrhea in hospitalized children ages 6 to 24 months, it is most common during dry, cold months of the year, and it may occur in electrophoretype restricted epidemics. Such analyses throughout Brazil will assist in developing sound guidelines regarding its prevention.

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“…Estudos dirigidos ao primeiro aspecto se desenvolveram nas regiões norte , central (Ishak et al, 1984), e sudeste (Salles- Gomes et al, 1983;Azeredo et al, 1989) do Brasil. No contexto dessas investigações soroepidemiológicas, observou-se que aproximadamente 70% das crianças, já aos 4-5 anos de idade, infectaram-se por rotavírus, em consonância com achados de inúmeros outros estudos no mundo (Kapikian & Chanock, 1996).…”

Section: Características Da Imunidade Para Rotavírus Em Populações Urunclassified

Epidemiologia das infecções por rotavírus no Brasil e os desafios para o seu controle

Linhares

2000

Cad. Saúde Pública

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Soroepidemiologia de rotavírus em uma população infantil, Goinia, Goiás, Brasil

Cited by 9 publications

References 18 publications

Humoral immunity patterns based on antibody reactivity to rotavirus antigens in Brazilian children under 5 years of age

Humoral immunity patterns based on antibody reactivity to rotavirus antigens in Brazilian children under 5 years of age

Epidemiological aspects of rotavirus infections in Minas Gerais, Brazil

Epidemiologia das infecções por rotavírus no Brasil e os desafios para o seu controle

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