Sore Throat, Tonsillitis, and Adenoiditis

Richardson, Mark A.

doi:10.1016/s0025-7125(05)70088-2

Cited by 41 publications

(44 citation statements)

References 9 publications

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“…It is thought that hypertrophied tonsils have increased pathogenic bacteria compared with nondiseased tonsils. 15 Indeed, when aspirates of normal tonsils 16 are compared with those of hypertrophied tonsils, the hypertrophied tonsils have more bacterial isolates. A study that compared tonsillar microbial flora in hypertrophied tonsils and tonsils with recurrent infection found that the 2 groups did not differ significantly in the number of isolates per patient, of either aerobic (3.8 vs 4.3) or anaerobic (5.2 vs 4.7) bacteria.…”

Section: Commentmentioning

confidence: 99%

Anatomical Evidence of Microbial Biofilms in Tonsillar Tissues

Chole

Faddis²

2003

Arch Otolaryngol Head Neck Surg

161

122

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Section: Commentmentioning

confidence: 99%

Anatomical Evidence of Microbial Biofilms in Tonsillar Tissues

Chole

Faddis²

2003

Arch Otolaryngol Head Neck Surg

161

122

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“…Tonsillectomy is 1 of the 10 most commonly performed procedures in outpatient centers. 1 Postoperative pain is the most common complication of the surgical procedure, followed by respiratory distress and airway obstruction, postoperative hemorrhage, and changes in speech that are usually temporary. 2'3 Infection following tonsillectomy is uncommon, 4 and nasopharyngeal stenosis, atlantoaxial subluxation, meningitis, depression, and death are extremely rare.…”

Section: Introductionmentioning

confidence: 99%

Comparison of benzydamine hydrochloride and Salvia officinalis as an adjuvant local treatment to systemic nonsteroidal anti-inflammatory drug in controlling pain after tonsillectomy, adenoidectomy, or both: an open-label, single-blind, randomized clinical trial

Lalićević¹,

Djordjević²

2004

Current Therapeutic Research

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Background: Benzydamine hydrochloride (BNZD) is a nonsteroidal antiinflammatory drug (NSAID) used in an oral rinse formulation as an adjuvant to other NSAIDs in controlling postoperative pain after tonsillectomy, adenoidectomy, or both. Salvia officinalis (SO) is a topically applied herbal preparation frequently used for the same indication. Pain, bleeding, and infection are the most common postoperative complications of tonsillectomy.Objective: The aim of this study was to compare the efficacy and tolerability of BNDZ with those of SO as adjuvant treatments in controlling postoperative pain.Methods: This open-label, single-blind, randomized clinical trial was conducted at the Department of Otorhinolaryngology, Clinical Hospital Center "Dr. Dragi~a Mi~ovi~--Dedinje" (Belgrade, Serbia and Montenegro). Pediatric and adult patients undergoing tonsillectomy, adenoidectomy, or both were enrolled. Patients were randomized to receive BNZD or SO, in addition to ibuprofen 20 mg/kg.d (children) or diclofenac 100 mg/d (adults). The primary end point was the proportion of patients with mild or no pain on postoperative days 1, 2, 4, and 7. Secondary end points were the incidences of infection, hemorrhage, and other adverse events. Results: S. Lali~evi6 and L Djordjevi~time point (P < 0.01 at days 1 and 4; P < 0.001 at days 2 and 7). In children, the risk for postoperative infection was similar between BNZD and SO (absolute risk reduction [ARR], 6.9%; 95% CI, 6.4%-?.6%); however, the risk was reduced in adults (ARR, 19.0%; 95% CI, 16.5%-21.9%; P = 0.008). Conclusions:In this clinical trial of children and adults who underwent tonsillectomy, adenoidectomy, or both, BNZD, as an adjuvant to an NSAID, was more effective than SO in controlling postoperative pain and infection. The pain-reducing effect of BNZD was of quick onset and persisted for 1 week after surgery. The safety profile of BNZD was comparable to that of SO, with the exception of postoperative infection in adults, for which BNZD was more efficacious. In particular, the use of BNZD was not associated with a high risk for early postoperative hemorrhage. (Curt Ther Res Clin Exp.

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“…Adenotonsillar hypertrophy is responsible in 80% of the cases with obstructive sleep apnea and sleep disturbances related to the respiratory system in children (17). The American Pediatrics Academy considered growth failure as a severe complication of untreated obstructive sleep apnea (18).…”

Section: Discussionmentioning

confidence: 99%

Çocuklarda kronik adenotonsiller hipertrofinin büyüme üzerine etkilerinin adenotonsillektomi öncesi ve sonrası dönemde değerlendirilmesi

...

2012

Tpa

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Aim: Several factors including genetic factors, nutrition and environment play a critical role in the growth of children. Adenotonsillar hypertrophy (ATH) can cause growth retardation by obstructing the upper airway. Surgical treatment of ATH has been considered to have a positive effect on growth. The aim of this study was to evaluate the role of chronic ATH on growth by measuring weight, height, body mass index (BMI), bone age, serum insulin-like growth factor 1 (IGF-1) and insulin-like growth factor binding protein 3 (IGFBP-3) values before and after adenotonsillectomy. Material and Method: The study was approved by the Ethics Committee (4.5.2004; 04/170) and written informed consents were obtained from parents of the participants. A total of 40 prepubertal children who were diagnosed as chronic ATH were enrolled. Obstructive symptoms were questioned in the medical history before surgery. Weight, height, BMI and bone age values were measured and compared with reference values. Preoperative serum IGF-1 and IGFBP-3 values were compared with the control group which consisted of healthy children. Rates of obstructive symptoms, weight, height, BMI, bone age, serum IGF-1 and IGFBP-3 values of the patients were determined seven months after adenotonsillectomy and were compared with preoperative values. Results: Obstructive symptoms in children with ATH decreased remarkably after surgery. Preoperative mean value of bone age of the patients was statistically lower than reference values (p<0.05) and mean value of serum IGF-1 was lower than than the control group (p<0.05). IGF-1 and IGFBP-3 values did not increase significantly after surgery (p>0.05). However, growth retardation was detected in three out of 40 patients based on the anthropometric measurements. Conclusions: In this study, antropometric findings showed that chronic ATH did not cause significant growth retardation in prepubertal children. In addition, we could not prove that surgical treatment of ATH improved the growth in the postoperative follow-up period of seven months. This result may be related with our study population with a limited number of patients who had baseline growth retardation and short postoperative follow up period. Further studies with large number of patients and longer postoperative follow-up periods are required to determine the exact role of chronic ATH in growth retardation. (Turk Arch Ped 2012; 47: 257-262)

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Sore Throat, Tonsillitis, and Adenoiditis

Cited by 41 publications

References 9 publications

Anatomical Evidence of Microbial Biofilms in Tonsillar Tissues

Anatomical Evidence of Microbial Biofilms in Tonsillar Tissues

Comparison of benzydamine hydrochloride and Salvia officinalis as an adjuvant local treatment to systemic nonsteroidal anti-inflammatory drug in controlling pain after tonsillectomy, adenoidectomy, or both: an open-label, single-blind, randomized clinical trial

Çocuklarda kronik adenotonsiller hipertrofinin büyüme üzerine etkilerinin adenotonsillektomi öncesi ve sonrası dönemde değerlendirilmesi

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