Sorbitan Sesquioleate

Castanedo-Tardan, Mari Paz; Jacob, Sharon E.

doi:10.2310/6620.2008.07070

Cited by 5 publications

(15 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…2,8 Topical pharmaceuticals such as corticosteroid ointments, antifungal creams, antibiotic creams and topical retinoids are important sources of contact allergy to SSO. 1,[5][6][7] Similar to our findings, European studies have reported that SSO sensitization was mainly induced by cosmetic/skin care products and by topical medicaments other than corticosteroids. 13,14 By contrast, topical corticosteroids were regarded as a more or equally frequent cause of SSO contact sensitization in the USA.…”

Section: Discussionsupporting

confidence: 91%

“…9 It is commonly used as an emulsifier in both leave-on and rinse-off cosmetic and skincare products, topical pharmaceuticals, wound dressings, inks, paints and metalworking oils. 1,3 Makeup, cleansers, sunscreens, exfoliants, moisturizers, toothpaste, nappy (diaper) creams and baby oils are among skincare products that may include SSO. 2,8 Topical pharmaceuticals such as corticosteroid ointments, antifungal creams, antibiotic creams and topical retinoids are important sources of contact allergy to SSO.…”

Section: Discussionmentioning

confidence: 99%

“…1 It is a non-ionic surfactant functioning as a water-in-oil emulsifier 1,2 and it also increases skin permeability. 1 Allergic contact dermatitis (ACD) can occur from various products containing this emulsifier, including cosmetics, personal care items and topical pharmaceuticals. 1,3,4 Recent reports from the USA indicated an increased frequency of positive patch test reactions to SSO, [4][5][6][7] and it is therefore included in the American Core series of patch test allergens in 2009.…”

Section: Introductionmentioning

confidence: 99%

“…1 Allergic contact dermatitis (ACD) can occur from various products containing this emulsifier, including cosmetics, personal care items and topical pharmaceuticals. 1,3,4 Recent reports from the USA indicated an increased frequency of positive patch test reactions to SSO, [4][5][6][7] and it is therefore included in the American Core series of patch test allergens in 2009. 8 However, the frequency of SSO-induced ACD in Europe is relatively low, and SSO is not yet included in either the classic or comprehensive European baseline series.…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Sorbitan sesquioleate: a rare contact allergen that is also an important indicator of allergic contact dermatitis from crossreacting compounds as well as for false‐positive fragrance allergy

Özkaya

Pehlivan

Kobaner

2022

Clin Experimental Derm

View full text Add to dashboard Cite

Summary Background Controversy exists about the addition of sorbitan sesquioleate (SSO) to the European baseline series for concomitant patch testing, particularly with fragrance mix (FM) I and Myroxylone pereirae (MP), which both contain SSO as an emulsifier. Aim To investigate SSO contact sensitization and concomitant positive patch test reactions to FM I or MP in Turkey. Methods This was a retrospective analysis of 840 patients consecutively patch tested with SSO 20% petrolatum between 1996 and 2020. Results The prevalence of SSO sensitization was 0.6% (5 of 840). In four of the five patients, clinical relevance could be established from SSO crossreactants, mainly in moisturizers and topical pharmaceuticals other than corticosteroids. Positive patch test reactions with unknown clinical relevance were observed to FM I or MP (both containing 5% SSO) in 71.4% of patients with a positive/questionable positive reaction to SSO (P < 0.001) and to other patch test allergens containing 1–5% SSO. Conclusions SSO was a very good indicator for positive patch test reaction with unknown clinical relevance to fragrances and other allergens containing 1–5% SSO. We suggest that SSO should be tested as a negative control with any commercially available patch test allergen containing SSO at any concentration. Moreover, clinicians should be alert for SSO synonyms and for other sorbitan derivatives in product labels, as SSO itself might not be the culprit but an indicator for crossreacting allergens.

show abstract

Section: Discussionsupporting

confidence: 91%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Sorbitan sesquioleate: a rare contact allergen that is also an important indicator of allergic contact dermatitis from crossreacting compounds as well as for false‐positive fragrance allergy

Özkaya

Pehlivan

Kobaner

2022

Clin Experimental Derm

View full text Add to dashboard Cite

show abstract

“…14,25 Therefore, several researchers have postulated that a positive allergic reaction to a test mixture actually could be due to the emulsifier and reiterated the importance of patch testing the individual components of the mixture, in addition to the test mixture itself, to properly identify the contact allergen. 14,[25][26][27][28][29] Case reports. Several case studies of patients with diseased skin have been described (Table 9).…”

Section: Dermalmentioning

confidence: 99%

Safety Assessment of Sorbitan Esters as Used in Cosmetics

Fiume¹,

Bergfeld²,

Belsito³

et al. 2019

Int J Toxicol

View full text Add to dashboard Cite

The Cosmetic Ingredient Review Expert Panel (Panel) assessed the safety of 20 sorbitan esters; this report included sorbitan esters that were reviewed in 1985 and 2002, as well as 3 previously unreviewed sorbitan esters (sorbitan undecylenate, sorbitan sesquicaprylate, and sorbitan palmate). Most of the sorbitan esters are reported to function in cosmetics as surfactant-emulsifying agents. The Panel reviewed the data from previous sorbitan ester reports, as well as additional data included in this report, to determine the safety of these ingredients. The Panel concluded that the sorbitan esters included in this safety assessment are safe in cosmetics in the present practices of use and concentration.

show abstract