Sorafenib Loaded Inhalable Polymeric Nanocarriers against Non-Small Cell Lung Cancer

Shukla, Snehal K.; Kulkarni, Nishant S.; Farrales, Pamela; Kanabar, Dipti; Parvathaneni, Vineela; Kunda, Nitesh K.; Gupta, Vivek

doi:10.1007/s11095-020-02790-3

Cited by 45 publications

(20 citation statements)

References 43 publications

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“…Pulmonary drug deposition of the AL-Rem formulation was evaluated using a Next Generation Impactor (NGI) 170 (MSP Corporation, MN, USA) as described previously [ 24 ]. A stainless steel induction port (i.e., United States Pharmacopeia throat adaptor attachment) and specialized stainless steel NGI ™ gravimetric insert cups (model 170; MSP Corporation) were attached to the NGI.…”

Section: Methodsmentioning

confidence: 99%

Aerosolized nanoliposomal carrier of remdesivir: an effective alternative for COVID-19 treatmentin vitro

et al. 2021

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Aim: To formulate an aerosolized nanoliposomal carrier for remdesivir (AL-Rem) against coronavirus disease 2019. Methods: AL-Rem was prepared using modified hydration technique. Cytotoxicity in lung adenocarcinoma cells, stability and aerodynamic characteristics of developed liposomes were evaluated. Results: AL-Rem showed high encapsulation efficiency of 99.79%, with hydrodynamic diameter of 71.46 ± 1.35 nm and surface charge of -32 mV. AL-Rem demonstrated minimal cytotoxicity in A549 cells and retained monolayer integrity of Calu-3 cells. AL-Rem showed sustained release, with complete drug release obtained within 50 h in simulated lung fluid. Long-term stability indicated >90% drug recovery at 4°C. Desirable aerosol performance, with mass median aerodynamic diameter of 4.56 ± 0.55 and fine particle fraction of 74.40 ± 2.96%, confirmed successful nebulization of AL-Rem. Conclusion: AL-Rem represents an effective alternative for coronavirus disease 2019 treatment.

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Section: Methodsmentioning

confidence: 99%

Aerosolized nanoliposomal carrier of remdesivir: an effective alternative for COVID-19 treatmentin vitro

et al. 2021

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“…Sorafenib is a receptor tyrosine kinase (RTK) inhibitor approved by the Food and Drug Administration (FDA). The sorafenib is extensively applied in the treatment of different cancers with high efficacy [99,100]. The NOB can be co-administered with sorafenib to elevate its antitumor activity.…”

Section: Nobiletin and Chemotherapymentioning

confidence: 99%

Nobiletin in Cancer Therapy: How This Plant Derived-Natural Compound Targets Various Oncogene and Onco-Suppressor Pathways

et al. 2020

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Cancer therapy is a growing field, and annually, a high number of research is performed to develop novel antitumor drugs. Attempts to find new antitumor drugs continue, since cancer cells are able to acquire resistance to conventional drugs. Natural chemicals can be considered as promising candidates in the field of cancer therapy due to their multiple-targeting capability. The nobiletin (NOB) is a ubiquitous flavone isolated from Citrus fruits. The NOB has a variety of pharmacological activities, such as antidiabetes, antioxidant, anti-inflammatory, hepatoprotective, and neuroprotective. Among them, the antitumor activity of NOB has been under attention over recent years. In this review, we comprehensively describe the efficacy of NOB in cancer therapy. NOB induces apoptosis and cell cycle arrest in cancer cells. It can suppress migration and invasion of cancer cells via the inhibition of epithelial-to-mesenchymal transition (EMT) and EMT-related factors such as TGF-β, ZEB, Slug, and Snail. Besides, NOB inhibits oncogene factors such as STAT3, NF-κB, Akt, PI3K, Wnt, and so on. Noteworthy, onco-suppressor factors such as microRNA-7 and -200b undergo upregulation by NOB in cancer therapy. These onco-suppressor and oncogene pathways and mechanisms are discussed in this review.

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“…Cur-loaded phenylboronic acid-containing framboidal NPs was able to improve the chemical stability of Cur and maintained the release of Cur under physiological conditions [139]. In lung cancer treatment, platinum-curcumin complexes were loaded into pH and redox dual-responsive NPs which showed effective intracellular drug release [140] while sorafenib (SF)-loaded cationically-modified polymeric NPs released the drugs through aerosolization of NPs [141]. Naringenin-loaded hyaluronic acid decorated PCL NPs also facilitated drug delivery in NSCLC cells [142].…”

Section: Polymeric Nanomaterials Targeting Various Cancersmentioning

confidence: 99%

“…PteCUR@PSPPN enhanced the anti-metastatic activity by blocking the PI3K/AKT signal transduction pathway [140]. Sorafenib (SF)-loaded cationically-modified polymeric NPs enhanced the inhibition of cell migration, reduced cell survival, and inhibited the clonogenic formation [141]. Table 1 summarizes various types of polymer-assisted NPs used for cancer therapies and their functions.…”

Section: Polymeric Nanomaterials Targeting Various Cancersmentioning

confidence: 99%

Development of Polymer-Assisted Nanoparticles and Nanogels for Cancer Therapy: An Update

Neerooa

Ooi

Shameli

et al. 2021

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With cancer remaining as one of the main causes of deaths worldwide, many studies are undergoing the effort to look for a novel and potent anticancer drug. Nanoparticles (NPs) are one of the rising fields in research for anticancer drug development. One of the key advantages of using NPs for cancer therapy is its high flexibility for modification, hence additional properties can be added to the NPs in order to improve its anticancer action. Polymer has attracted considerable attention to be used as a material to enhance the bioactivity of the NPs. Nanogels, which are NPs cross-linked with hydrophilic polymer network have also exhibited benefits in anticancer application. The characteristics of these nanomaterials include non-toxic, environment-friendly, and variable physiochemical properties. Some other unique properties of polymers are also attributed by diverse methods of polymer synthesis. This then contributes to the unique properties of the nanodrugs. This review article provides an in-depth update on the development of polymer-assisted NPs and nanogels for cancer therapy. Topics such as the synthesis, usage, and properties of the nanomaterials are discussed along with their mechanisms and functions in anticancer application. The advantages and limitations are also discussed in this article.

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Sorafenib Loaded Inhalable Polymeric Nanocarriers against Non-Small Cell Lung Cancer

Cited by 45 publications

References 43 publications

Aerosolized nanoliposomal carrier of remdesivir: an effective alternative for COVID-19 treatmentin vitro

Aerosolized nanoliposomal carrier of remdesivir: an effective alternative for COVID-19 treatmentin vitro

Nobiletin in Cancer Therapy: How This Plant Derived-Natural Compound Targets Various Oncogene and Onco-Suppressor Pathways

Development of Polymer-Assisted Nanoparticles and Nanogels for Cancer Therapy: An Update

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