2015
DOI: 10.1016/s1470-2045(14)71136-2
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Sorafenib and everolimus for patients with unresectable high-grade osteosarcoma progressing after standard treatment: a non-randomised phase 2 clinical trial

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Cited by 278 publications
(241 citation statements)
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References 45 publications
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“…Combination targeted therapy again may have merit: a phase II trial of sorafenib and everolimus combination therapy achieved 45% 6-month progression-free survival (PFS; ref. 70). Although falling just short of its prespecified primary endpoint (50% 6-month PFS), this result is well-above the widely accepted 20% 6-month PFS benchmark for sarcoma drug activity (71) and represents the first positive study for relapsed osteosarcoma in a quarter century.…”
Section: Sarcoma Treatment: Current and Future Prospectsmentioning
confidence: 80%
“…Combination targeted therapy again may have merit: a phase II trial of sorafenib and everolimus combination therapy achieved 45% 6-month progression-free survival (PFS; ref. 70). Although falling just short of its prespecified primary endpoint (50% 6-month PFS), this result is well-above the widely accepted 20% 6-month PFS benchmark for sarcoma drug activity (71) and represents the first positive study for relapsed osteosarcoma in a quarter century.…”
Section: Sarcoma Treatment: Current and Future Prospectsmentioning
confidence: 80%
“…Although 45% of the patients presented six months of progression-free survival, the target of 50% was not reached. 62 …”
Section: Pi3k/akt/mtor Pathwaymentioning
confidence: 99%
“…In an effort to increase sorafenib's effects, one promising strategy is to combine sorafenib with other anticancer reagents (19,20). However, the outcomes of several of these studies were not desirable due to safety concerns or not achieving the expected end point such as improved overall survival (21,22).…”
Section: Introductionmentioning
confidence: 99%