Sophorolipids Decrease IgE Production in U266 Cells.

Bluth, Martin H.; Smith‐Norowitz, Tamar A.; Hagler, M.; Beckford, Roy; Chice, Seto; Shah, Vishal; Gross, Richard A.; Nowakowski, Maja; Schulze, Robert; Zenilman, Michael E.

doi:10.1016/j.jaci.2005.12.797

Cited by 5 publications

(2 citation statements)

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“…The mechanisms involved in these studies included a decrease in nitric oxide production and proinflammatory cytokines [2,5,7]. Recent studies in our laboratory also demonstrated the utility of sophorolipids in atopic disease [11]; sophorolipids were able to decrease IgE production in a dose-dependent manner and used mechanisms involving the reduction of IgErelated genes, including BSAP (Pax5) and IL-6 among others [12]. In all cases, there were no deleterious effects to the host or somatic cell lines in vitro and in vivo at therapeutic doses.…”

Section: Discussionmentioning

confidence: 98%

Sophorolipids Improve Sepsis Survival: Effects of Dosing and Derivatives

Hardin

Pierre

Schulze

et al. 2007

Journal of Surgical Research

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Section: Discussionmentioning

confidence: 98%

Sophorolipids Improve Sepsis Survival: Effects of Dosing and Derivatives

Hardin

Pierre

Schulze

et al. 2007

Journal of Surgical Research

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“…Sophorolipids (SLs) from C. bombicola decreased immunoglobulin E (IgE) level, mRNA expression of TLR-2, IL-6 and STAT3 and lung inflammation [ 21 , 22 ]. Hence, the study demonstrated that SLs down-regulate the IgE coding genes, thereby acting as an anti-inflammatory agent and potential therapeutic compound [ 21 , 23 ]. In an experimental rat model, SLs reduced sepsis-related mortality and observed predicted to display anti-inflammatory effects [ 24 , 25 ].…”

Section: Anti-inflammatory Potential Of Bssmentioning

confidence: 99%

Biosurfactants and anti-inflammatory activity: A potential new approach towards COVID-19

Subramaniam

Venkatesan

Iyer

et al. 2020

Current Opinion in Environmental Science & Health

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Coronavirus Disease 2019 (COVID-19) has grown to be global public health emergency. The biosurfactants (BSs) are surface-active biomolecules with unique properties and wide applications. Several microbes synthesize secondary metabolites with surface-active properties which has wide range of anti-inflammatory and anti-viral role.. The monocytes and neutrophils are activated by bacteria which subsequently result in high secretion of pro-inflammatory cytokines (TNF-α, IL-6, IL-8, IL-12, Il-18 and IL-1β) and toll-like receptors-2 (TLR-2). Following the inflammatory response, BSs induce the production of cationic proteins, reactive oxygen species (ROS) and lysozyme, and thus can be utilized for therapeutic purposes. This review provides recent advances in the anti-inflammatory and antiviral activities of biosurfactants and discusses the potential use of these compounds against COVID-19, highlighting the need for in-vitro and in-vivo approaches to confirm this hypothesis. This suggestion is necessary because there are still no studies that have focused on the use of biosurfactants against COVID-19.

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