Sophoraflavanone G Inhibits RANKL-Induced Osteoclastogenesis via MAPK/NF-κB Signaling Pathway

Li, Xinchun; Deng, Wei; Tang, Kai; Zhang, Shiyin; Liang, Zixuan; Liu, Weiwen; Li, Yongyu; Zhang, Zhida; Zhao, Wenhua; Zou, Jian

doi:10.1007/s12033-024-01185-8

Cited by 1 publication

(1 citation statement)

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“…TYK2 is also able to activate the guanosine nucleotide exchange factors vav, which subsequently activates small G proteins RAS and Rac1, ultimately leading to activation of downstream MAPK kinases and downstream signaling cascades ( 34 ). The two pathways play an important role in cell proliferation, differentiation, apoptosis etc ( Figure 1B ) ( 35 , 36 ).…”

Section: Signaling Pathways For Ifn-i Production and Functionmentioning

confidence: 99%

Mutual regulations between Toxoplasma gondii and type I interferon

Song,

Wang,

Cao

et al. 2024

Front. Immunol.

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In the decades since the discovery, Type I interferon (IFN-I) has been intensively studied for their antiviral activity. However, increasing evidences suggest that it may also play an important role in the infection of Toxoplasma gondii, a model organism for intracellular parasites. Recent studies demonstrated that the induction of IFN-I by the parasite depends on cell type, strain genotype, and mouse strain. IFN-I can inhibit the proliferation of T. gondii, but few studies showed that it is beneficial to the growth of the parasite. Meanwhile, T. gondii also can secrete proteins that impact the pathway of IFN-I production and downstream induced interferon-stimulated genes (ISGs) regulation, thereby escaping immune destruction by the host. This article reviews the major findings and progress in the production, function, and regulation of IFN-I during T. gondii infection, to thoroughly understand the innate immune mechanism of T. gondii infection, which provides a new target for subsequent intervention and treatment.

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Section: Signaling Pathways For Ifn-i Production and Functionmentioning

confidence: 99%