Sophora flavescens-Angelica sinensis in the treatment of eczema by inhibiting TLR4/MyD88/NF-κB pathway

Sun, Peng; Zhao, Xiangfeng; Zhao, Wenjie; Chen, Lele; Liu, Xinyue; Zhan, Zhaoshuang; Wang, Jiafeng

doi:10.1016/j.jep.2023.117626

Cited by 2 publications

(1 citation statement)

References 28 publications

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“…( S. flavescens ) is widely used in the clinic, can clear dampness-heat, kill insects, and dispel wind evil, which originates from the teachings of traditional Chinese medicine [ 11 ]. S. flavescens has been clinically used in numerous countries to treat skin diseases [ 12 , 13 ]. Kushenol F (KSCF) is a natural isopentenyl flavonoid extracted from the root of S. flavescens .…”

Section: Introductionmentioning

confidence: 99%

Metabolic Profiling for Unveiling Mechanisms of Kushenol F against Imiquimod-Induced Psoriasis with UHPLC/MS Analysis

Yang,

Cheng,

Yin

et al. 2024

Molecules

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Psoriasis is a common chronic immune-mediated inflammatory skin disorder. Sophora flavescens Alt. (S. flavescens) has been widely acknowledged in the prevention and treatment of psoriasis. Kushenol F (KSCF) is a natural isopentenyl flavonoid extracted from the root of S. flavescens. We aimed to investigate the effect and mechanism of KSCF on imiquimod (IMQ)-induced psoriasis-like skin lesions in mice. A mouse model of psoriasis was induced with 5% IMQ for 5 days, and the mice were given KSCF dermally for 5 days. Changes in skin morphology, the psoriasis area, the severity index (PASI), and inflammatory factors of psoriasis-like skin lesions were evaluated. Metabolites in the psoriasis-like skin lesions were analyzed with ultra-high-performance liquid chromatography/mass spectrometry followed by a multivariate statistical analysis to identify the differential metabolites and metabolic pathway. The results of the present study confirmed that KSCF significantly reduced PASI scores, epidermal thickening, and epidermal cell proliferation and differentiation. KSCF also reduced the levels of interleukin (IL)-1β, IL-6, IL-8, IL-17A, IL-22, IL-23, and tumor necrosis factor (TNF)-α in the injured skin tissues while increasing IL-10 content. KSCF significantly regulated metabolites in the skin samples, and a total of 161 significant metabolites were identified. These differential metabolites involved sphingolipid and linoleic acid metabolism and steroid hormone biosynthesis. Collectively, KSCF inhibited the inflammatory response to prevent IMQ-induced psoriasis-like skin lesions in mice by call-backing the levels of 161 endogenous metabolites and affecting their related metabolic pathways. KSCF has the potential to be developed as a topical drug for treating psoriasis symptoms.

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Section: Introductionmentioning

confidence: 99%

Metabolic Profiling for Unveiling Mechanisms of Kushenol F against Imiquimod-Induced Psoriasis with UHPLC/MS Analysis

Yang,

Cheng,

Yin

et al. 2024

Molecules

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Discrimination between raw and ginger juice processed Fructus Gardeniae based on UHPLC‐Q‐TOF‐MS and Heracles NEO ultra‐fast gas phase electronic nose

Fan,

Zhang,

Wang

et al. 2024

Phytochemical Analysis

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IntroductionFructus Gardeniae (ZZ), a traditional Chinese herb, has been used in treating patients with jaundice, inflammation, etc. When mixed with ginger juice and stir‐baked, ginger juice‐processed Fructus Gardeniae (JZZ) is produced, and the chemical compositions in ZZ would be changed by adding the ginger juice.ObjectiveTo illuminate the differential components between ZZ and JZZ.MethodsHPLC, UHPLC‐Q‐TOF‐MS, and Heracles NEO ultra‐fast gas phase electronic nose were applied to identify the differential components between ZZ and JZZ.ResultsHPLC fingerprints of ZZ and JZZ were established, and 24 common peaks were found. The content determination results showed that the contents of shanzhiside, geniposidic acid, genipin‐1‐β‐D‐gentiobioside and geniposide increased, while the contents of crocin I and crocin II decreased in JZZ. By UHPLC‐Q‐TOF‐MS, twenty‐six possible common components were inferred, among which 11 components were different. In further investigation, eight components were identified as the possible distinctive non‐volatile compounds between ZZ and JZZ. By Heracles NEO ultra‐fast gas phase electronic nose, four substances were inferred as the possible distinctive volatile compounds in JZZ.ConclusionShanzhiside, caffeic acid, genipin‐1‐β‐D‐gentiobioside, geniposide, rutin, crocin I, crocin II, and 4‐Sinapoyl‐5‐caffeoylquinic acid were identified as the possible differential non‐volatile components between ZZ and JZZ. Aniline, 3‐methyl‐3‐sulfanylbutanol‐1‐ol, E‐3‐octen‐2‐one, and decyl propaonate were inferred as the possible distinctive volatile compounds in JZZ. This experiment explored a simple approach with objective and stable results, which would provide new ideas for studying decoction pieces with similar morphological appearance, especially those with different odors.

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Sophora flavescens-Angelica sinensis in the treatment of eczema by inhibiting TLR4/MyD88/NF-κB pathway

Cited by 2 publications

References 28 publications

Metabolic Profiling for Unveiling Mechanisms of Kushenol F against Imiquimod-Induced Psoriasis with UHPLC/MS Analysis

Metabolic Profiling for Unveiling Mechanisms of Kushenol F against Imiquimod-Induced Psoriasis with UHPLC/MS Analysis

Discrimination between raw and ginger juice processed Fructus Gardeniae based on UHPLC‐Q‐TOF‐MS and Heracles NEO ultra‐fast gas phase electronic nose

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