Sonosensitized Aggregation-Induced Emission Dots with Capacities of Immunogenic Cell Death Induction and Multivalent Blocking of Programmed Cell Death-Ligand 1 for Amplified Antitumor Immunotherapy

Jia, Shaorui; Gao, Zhiyuan; Wu, Zelin; Hong, Gao; Wang, He; Ou, Hanlin; Ding, Dan

doi:10.31635/ccschem.021.202101458

Cited by 71 publications

(47 citation statements)

References 27 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This is most likely because of the mechanical damage that the vitreous injection operation itself caused as well as the inflammatory reaction brought on by the devastation of normal tissue by tumor proliferation. [ 37 ] In the without treatment group, IL‐6 and GFAP expression were up‐regulated by ≈six‐fold one week after modeling, but Caspase 3 altered the highest, by ≈5.6‐fold. The GFAP up‐regulation in the with treatment group decreased to less than 4 times for each of the inflammatory markers over the course of the next two weeks, whereas it was averaged at 15 times higher in the without treatment group.…”

Section: Resultsmentioning

confidence: 99%

Highly Efficient Photodynamic Therapy with Mitochondria‐Targeting Aggregation‐Induced Emission Photosensitizer for Retinoblastoma

Zhou

Chen

Chen³

et al. 2022

Adv Healthcare Materials

View full text Add to dashboard Cite

Retinoblastoma (RB) is an aggressive eye cancer in infancy and childhood, lethal by metastasis if left untreated. Currently, the survival rate and the chance of saving vision depend on the severity of the disease. In this work, a highly efficient photodynamic ophthalmic therapy for RB is reported by employing an isoquinolinium‐based aggregation‐induced‐emission (AIE) photosensitizer (PS) TPE‐IQ‐2O for photodynamic inactivation (PDI). TPE‐IQ‐2O is an efficient mitochondria‐targeting photosensitizer as an efficient guided photodynamic therapy (PDT) agent against cancer cells. Maximizing cancer‐selectively damage to tumors with minimized side effects on normal tissue is essential for effective anticancer PDT and provides long‐lasting protection against metastasis. In addition, TPE‐IQ‐2O can effectively reduce the degree of tissue inflammation by inhibiting the expression of related inflammatory factors. TPE‐IQ‐2O also exhibits excellent biocompatibility with a neglectable hemolysis effect on mouse red blood cells and almost no killing effect on mammalian cells, which enables its potential applications in the treatment of RB.

show abstract

Section: Resultsmentioning

confidence: 99%

Highly Efficient Photodynamic Therapy with Mitochondria‐Targeting Aggregation‐Induced Emission Photosensitizer for Retinoblastoma

Zhou

Chen

Chen³

et al. 2022

Adv Healthcare Materials

View full text Add to dashboard Cite

show abstract

“…Recent investigations on SDT have highlighted its ability to induce ICD [ 77 ] similarly to PDT, which is already recognized as a treatment modality that can induce this peculiar type of cell death [ 29 , 78 ]. SDT has been shown to work in a comparable way to PDT, relying on ROS production as well, whereas US has also shown immunomodulatory action [ 79 ].…”

Section: Discussionmentioning

confidence: 99%

Ultrasound Triggers Hypericin Activation Leading to Multifaceted Anticancer Activity

et al. 2022

View full text Add to dashboard Cite

The use of ultrasound (US) in combination with a responsive chemical agent (sonosensitizer) can selectively trigger the agent’s anticancer activity in a process called sonodynamic therapy (SDT). SDT shares some properties with photodynamic therapy (PDT), which has been clinically approved, but sets itself apart because of its use of US rather than light to achieve better tissue penetration. SDT provides anticancer effects mainly via the sonosensitizer-mediated generation of reactive oxygen species (ROS), although the precise nature of the underpinning mechanism is still under debate. This work investigates the SDT anticancer activity of hypericin (Hyp) in vitro in two- (2D) and three-dimensional (3D) HT-29 colon cancer models, and uses PDT as a yardstick due to its well-known Hyp phototoxicity. The cancer cell uptake and cellular localization of Hyp were investigated first to determine the proper noncytotoxic concentration and incubation time of Hyp for SDT. Furthermore, ROS production, cell proliferation, and cell death were evaluated after Hyp was exposed to US. Since cancer relapse and transporter-mediated multidrug resistance (MDR) are important causes of cancer treatment failure, the US-mediated ability of Hyp to elicit immunogenic cell death (ICD) and overcome MDR was also investigated. SDT showed strong ROS-mediated anticancer activity 48 h after treatment in both the HT-29 models. Specific damage-associated molecular patterns that are consistent with ICD, such as calreticulin (CRT) exposure and high-mobility group box 1 protein (HMGB1) release, were observed after SDT with Hyp. Moreover, the expression of the ABC transporter, P-glycoprotein (P-gp), in HT-29/MDR cells was not able to hinder cancer cell responsiveness to SDT with Hyp. This work reveals, for the first time, the US responsiveness of Hyp with significant anticancer activity being displayed, making it a full-fledged sonosensitizer for the SDT of cancer.

show abstract

“…Organic fluorescent probes can possess aggregation-induced emission (AIE) properties, which are valuable tools in biomedical applications due to their high photobleaching threshold, capacity to induce a large Stokes shift, and ability to activate fluorophore emission [ 103 , 104 ]. Biocompatible AIE offer an attractive tool to realize image-guided surgery and the live monitoring of diverse biological processes.…”

Section: Room-temperature Phosphorescence Imagingmentioning

confidence: 99%

Organic persistent luminescence imaging for biomedical applications

Midgley

Kong

2022

Materials Today Bio

Self Cite

View full text Add to dashboard Cite

Sonosensitized Aggregation-Induced Emission Dots with Capacities of Immunogenic Cell Death Induction and Multivalent Blocking of Programmed Cell Death-Ligand 1 for Amplified Antitumor Immunotherapy

Cited by 71 publications

References 27 publications

Highly Efficient Photodynamic Therapy with Mitochondria‐Targeting Aggregation‐Induced Emission Photosensitizer for Retinoblastoma

Highly Efficient Photodynamic Therapy with Mitochondria‐Targeting Aggregation‐Induced Emission Photosensitizer for Retinoblastoma

Ultrasound Triggers Hypericin Activation Leading to Multifaceted Anticancer Activity

Organic persistent luminescence imaging for biomedical applications

Contact Info

Product

Resources

About