Sonography in patients with a possible pancreatic mass shown on CT

Ormson, MJ; Charboneau, J. William; Stephens, DH

doi:10.2214/ajr.148.3.551

Cited by 25 publications

(7 citation statements)

References 7 publications

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“…However, the deep retroperitoneal tissue surrounding the pancreas is better seen by CT than by transabdominal US. The entire gland can be seen by transabdominal US in only about 25% of subjects . The results of this imaging modality are dependent on multiple variables, such as the skill of the examiner, patient body habitus, and the presence or absence of overlying loops of gas‐filled bowel.…”

Section: Diagnosismentioning

confidence: 99%

“…The results of this imaging modality are dependent on multiple variables, such as the skill of the examiner, patient body habitus, and the presence or absence of overlying loops of gas‐filled bowel. On US, a pancreatic carcinoma typically appears as a poorly defined, hypoechoic, hypovascular solid mass . The sensitivity of transabdominal US imaging in the diagnosis of pancreatic cancer has varied based on the experience of several investigators, and has ranged from as low as 44%113 to as high as 94% 117…”

Section: Diagnosismentioning

confidence: 99%

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Hereditary factors in pancreatic cancer

Lynch

Brand

Lynch

et al. 2002

Journal of Hepato-Biliary-Pancreatic Surgery

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The incidence and the mortality rates for pancreatic cancer are the same, indicating its dismal outlook. Its natural history remains elusive. Cigarette smoking appears to be the most significant environmental culprit. Hereditary factors may account for approximately 5% of the total pancreatic cancer burden. However, when its extant heterogeneity and the reduced penetrance of causal germline mutations are considered, the hereditary incidence may significantly exceed this estimate. Even when endoscopic ultrasound (EUS), the gold standard for pancreatic cancer screening, is utilized, early detection with surgical cure has rarely been accomplished. Needed to ameliorate this problem is research into genetic and environmental risk factors and their interaction. The identification of tumor biomarkers which signal early pathogenetic events, thereby enabling pancreatic cancer to be diagnosed at its earliest possible stage before it has spread to regional lymph nodes or to more distant sites, will improve the outlook. We discuss our research approaches to this problem. Members of families with the p16 germline mutation will undergo EUS coupled with the collection of pancreatic juice for the study of a possible gradient for telomerase activity, K- ras mutations, and cytology. If changes in these putative biomarkers are observed, endoscopic retrograde cholangiopancreatography (ERCP) would be the next diagnostic step. We conclude with a discussion of ethical concerns about this research.

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Section: Diagnosismentioning

confidence: 99%

Section: Diagnosismentioning

confidence: 99%

Hereditary factors in pancreatic cancer

Lynch

Brand

Lynch

et al. 2002

Journal of Hepato-Biliary-Pancreatic Surgery

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“…However, the deep retroperitoneal tissue surrounding the pancreas is better seen by CT than by US. The entire gland can be seen by US in only about 25% of the cases [16][17][18]. The results of this imaging modality are dependent on multiple variables such as the skill of the examiner, patient body habitus, and the presence or absence of overlying loops of gas-filled bowel.…”

Section: Ultrasound (Us)mentioning

confidence: 99%

“…On US, an adenocarcinoma of the pancreas typically appears as a poorly defined, hypoechoic, hypovascular solid mass [2,[17][18][19]. Enlargement of the pancreas and extension into the surrounding soft tissues can, at times, be seen by US.…”

Section: Ultrasound (Us)mentioning

confidence: 99%

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Imaging Techniques in the Evaluation of Adenocarcinoma of the Pancreas

Brand¹,

Matamoros²

1998

Dig Dis

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Adenocarcinoma of the pancreas is a highly malignant neoplasm that presents late and carries a dismal prognosis. Despite technical advances, the various imaging modalities used to evaluate and stage a pancreatic adenocarcinoma have not had a significant impact on survival rates. This article describes the various imaging modalities used to image and stage an adenocarcinoma of the pancreas and reviews their relative accuracy and limitations in diagnosing and staging this carcinoma. We conclude that for appropriate staging of adenocarcinoma of the pancreas, the combination of a computed axial tomography scan and an endoscopic ultrasound represents an efficient and cost-effective approach.

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