Sonographic findings of localized Castleman disease of the abdomen and pelvis

Zhou, Wei; Zhan, Wei; Zhou, Jinhua; Zhu, Ying; Yao, Jiejie

doi:10.1002/jcu.22245

Cited by 8 publications

(3 citation statements)

References 18 publications

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“…Castleman disease, alternatively known as giant lymph node hyperplasia, is rarely localized in the adrenal glands . In previous reports, the lesions were hypoechoic and solid . We found that Castleman disease lesions in the abdomen and pelvis usually appeared as well‐demarcated homogeneous hypoechoic masses, with no vascularization.…”

Section: Discussionsupporting

confidence: 91%

Ultrasonographic Findings of 1385 Adrenal Masses: A Retrospective Study of 1319 Benign and 66 Malignant Masses

Gong

Zhan

2017

J of Ultrasound Medicine

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Section: Discussionsupporting

confidence: 91%

Ultrasonographic Findings of 1385 Adrenal Masses: A Retrospective Study of 1319 Benign and 66 Malignant Masses

Gong

Zhan

2017

J of Ultrasound Medicine

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“… 15 Ultrasound is particularly useful for guiding percutaneous biopsy. 16 MR imaging would likely not add any substantial new information beyond that provided by CT.…”

Section: Discussionmentioning

confidence: 99%

Abdominal CT findings characteristic of Castleman disease: multi-centre review of 76 adult cases with abdominopelvic nodal involvement

Pickhardt,

Wong,

Mellnick

et al. 2024

British Journal of Radiology

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OBJECTIVE Characterize the CT findings of abdominopelvic Castleman disease, including a new observation involving the perinodal fat. METHODS Multi-center search at 5 institutions yielded 76 adults (mean age, 42.1 ± 14.3 years; 38 women/38 men) meeting inclusion criteria of histopathologically-proven Castleman disease with nodal involvement at abdominopelvic CT. Retrospective review of the dominant nodal mass was assessed for size, attenuation, and presence of calcification, and for prominence and soft-tissue infiltration of the perinodal fat. Hypervascular nodal enhancement was based on both subjective and objective comparison with aortic blood pool attenuation. RESULTS Abdominal involvement was unicentric in 48.7% (37/76) and multicentric in 51.3% (39/76), including 31 cases with extra-abdominal involvement. Histopathologic subtypes included hyaline vascular variant (HVV), plasma cell variant (PCV), mixed HVV/PCV, and HHV-8 variant in 39, 25, 3 and 9 cases, respectively. The dominant nodal mass measured 4.4 ± 1.9 cm and 3.2 ± 1.7 cm in mean long- and short-axis, respectively, and appeared hypervascular in 58.6% (41/70 with IV contrast). Internal calcification was seen in 22.4% (17/76). Infiltration of the perinodal fat, with or without hypertrophy, was present in 56.6% (43/76), more frequent with hypervascular vs. non-hypervascular nodal masses (80.5% vs. 20.7%; p < 0.001). Among HVV cases, 76.9% were unicentric, 71.1% appeared hypervascular, and 69.2% demonstrated perinodal fat infiltration. CONCLUSION Hypervascular nodal masses demonstrating prominence and infiltration of perinodal fat at CT can suggest the specific diagnosis of Castleman disease, especially the hyaline vascular variant. ADVANCES IN KNOWLEDGE Abdominopelvic nodal masses that demonstrate hypervascular enhancement and prominent infiltration of the perinodal fat at CT can suggest the diagnosis of Castleman disease, but nonetheless requires tissue sampling.

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“…Internal echoes are homogeneous or not, and may be accompanied by fine strong echo separation or calcification. Most of the posterior echo is enhanced, with abundant feeding vessels in color doppler [ 5 , 6 ]. Generally speaking, the case we reported is similar to existing record in the literature.…”

Section: Discussion/conclusionmentioning

confidence: 99%

Perigastric Hyaline-Vascular Variant Castleman’s Disease

Jin

Jing

2021

Case Rep Gastroenterol

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Castleman disease (CD) is a rare chronic lymphoproliferative disease with unknown etiology and pathogenesis disease. When the lesion is located in the mediastinum, the diagnosis of CD is easy. However, if the lesion presents as a perigastric mass mimicking other subserosal gastric mesenchymal tumors, the diagnosis can be challenging. As few sonographic manifestations of hyaline-vascular variant CD, especially contrast-enhanced ultrasound (CEUS) imaging, as well as computed tomography (CT) and histopathological imaging, have been reported in literature, this case may provide a vivid example of a comprehensive CEUS and CT usage in the diagnosis and surgery with regard to CD. This report presents a case of a 50-year-old female diagnosed with hyaline-vascular variant CD in a random physical examination, the ultrasound examination first revealed a 24.3 mm × 15.4 mm hypoechogenic lesion abutting the stomach, esophagus, and liver, which was under the suspicion of gastrointestinal stromal tumor. Following a series of medical examinations, including CEUS, CT, postoperative histopathological examination, and immunohistochemical analysis, the patient was diagnosed with hyaline-vascular variant unicentric CD. After the mass was completely excised through laparoscopic surgery, the woman recovered very well without recurrence during a follow-up period of 15 months. Thus, mastering ultrasound and CT-imaging characteristics of CD and applying ultrasound and CT examination together would do help to preoperative diagnosis.

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Sonographic findings of localized Castleman disease of the abdomen and pelvis

Abstract: Localized Castleman disease in the abdomen and pelvis usually appears on US as a heterogeneously hypoechoic lesion containing thin septa, and more commonly than not, demonstrates posterior acoustic enhancement and marked vascularity.

Cited by 8 publications

References 18 publications

Ultrasonographic Findings of 1385 Adrenal Masses: A Retrospective Study of 1319 Benign and 66 Malignant Masses

Ultrasonographic Findings of 1385 Adrenal Masses: A Retrospective Study of 1319 Benign and 66 Malignant Masses

Abdominal CT findings characteristic of Castleman disease: multi-centre review of 76 adult cases with abdominopelvic nodal involvement

Perigastric Hyaline-Vascular Variant Castleman’s Disease

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