Sonographic evaluation of para- and perirenal fat thickness is an independent predictor of early kidney damage in obese patients

Sun, Xiaodong; Han, Fang; Miao, Wei; Hou, Ningning; Cao, Zhibin; Zhang, Guangdong

doi:10.1007/s11255-013-0404-4

Cited by 41 publications

(48 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Integrated endothelium plays a critical role in protecting the vasculature against atherosclerosis. Endothelial dysfunction, mainly endothelial-dependent vasorelaxation, has been observed in obesity-associated metabolic syndrome [10,21]. In our study, EDV was significantly impaired in diet-induced obese rats, but the EIV response to SNP did not change, which is consistent with previous studies [13,14,22].…”

Section: Cellular Physiology and Biochemistrysupporting

confidence: 93%

Induction of Haemeoxygenase-1 Directly Improves Endothelial Function in Isolated Aortas from Obese Rats through the Ampk-Pi3k/Akt-Enos Pathway

Han¹,

Guo

et al. 2015

Cell Physiol Biochem

Self Cite

View full text Add to dashboard Cite

Background: Induction of haemeoxygenase-1 (HO-1) increases adiponectin secretion by remodeling adipose tissue in obesity. The objective of our study is to explore whether HO-1 induction directly improves endothelial function independent of adiponectin changes in obese rats. Methods: Rats were divided into control and obesity groups. Aortic endothelial function was determined by measuring endothelium-dependent vasodilatation (EDV). Vascular segments of the obese rats were incubated in an organ bath in the presence or absence of cobalt protoporphyrin (CoPP) or CoPP plus stannous protoporphyrin. Nitric oxide (NO) production, superoxide anion production and NF-κB p65 expression in the aorta were determined. The expression of AMP-activated kinase (AMPK), Akt and endothelial nitric oxide synthase (eNOS) in endothelial cells was determined by western blotting. The aortic rings from the obese rats were then incubated with CoPP in the presence of specific inhibitors of AMPK, phosphatidylinositol 3-kinase (PI3K) or eNOS. Results: Acetylcholine-induced EDV was significantly attenuated in the obese rats, compared with the NC group (p < 0.05). Pre-incubation of vessels from obese rats with CoPP significantly increased EDV (p < 0.05). However, this beneficial effect of CoPP was partly attenuated in vitro in the presence of inhibitors of AMPK, PI3K or eNOS. HO-1 induction with CoPP significantly increased the activation of the AMPK-PI3K/Akt-eNOS pathway and NO production in parallel with reduced superoxide anion production and NF-κB p65 expression in obese rats. Conclusions: HO-1 induction with CoPP directly improved endothelial function in obese rats independent of adiponectin changes. The mechanism of this protective effect is related to increasing NO production by activation of the AMPK-PI3K/Akt-eNOS signaling pathway.

show abstract

Section: Cellular Physiology and Biochemistrysupporting

confidence: 93%

Induction of Haemeoxygenase-1 Directly Improves Endothelial Function in Isolated Aortas from Obese Rats through the Ampk-Pi3k/Akt-Enos Pathway

Han¹,

Guo

et al. 2015

Cell Physiol Biochem

Self Cite

View full text Add to dashboard Cite

show abstract

“…No study currently exists that analyzes this relationship in hypertensive patients, and the few previous data of literature involving only diabetic or obese patients provide conflicting results. In 151 type‐2 diabetic patients, Lamacchia et al described a strongly negative correlation between eGFR and PUFT, independently by BMI or WC, whereas no relationship between the variables was found by Sun et al in nonhypertensive nondiabetic obese patients, probably due to the exiguity of simple size or the young age of enrolled patients. In both reported studies, however, PUFT was compared and adjusted only for traditional anthropometric indexes of adiposity (BMI or WC), and no study compared PUFT with direct measurements of adiposity assessed by ultrasonography such as RA or CR (and RA/CR).…”

Section: Discussionmentioning

confidence: 93%

“…The ectopic fat around the kidneys could influence their function also through local mechanisms . First, PUFT secretes paracrine substances with functional or metabolic renal action that could play a key role in the development of nephropathy.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Para‐perirenal distribution of body fat is associated with reduced glomerular filtration rate regardless of other indices of adiposity in hypertensive patients

Geraci

Zammuto

Mattina

et al. 2018

J of Clinical Hypertension

View full text Add to dashboard Cite

Obesity is a well-known risk factor for the development and progression of chronic kidney disease. Recently, para-perirenal ultrasonographic fat thickness (PUFT) has shown to correlate with both total and visceral fat better than body mass index (BMI), waist circumference (WC), and other indices of obesity. Moreover, a local paracrine and mechanical action of the PUFT on kidney has been described in recent studies. Aim of our study was to assess the relationship between glomerular filtration rate (GFR) and PUFT in comparison with other anthropometric and ultrasonographic indices of adiposity. Two hundred and ninety-six hypertensive patients were enrolled. PUFT, cutis-rectis thickness and rectis-aorta thickness were obtained by ultrasonography. Anthropometric measures of adiposity were also measured. Estimated GFR was calculated using the CKD-EPI equation. Higher PUFT values were observed in patients with impaired renal function (P < 0.001), whereas no differences in BMI and WC were shown between groups divided by GFR. PUFT significantly correlated with GFR in all patients (r = -0.284; P < 0.001), with no differences in groups divided by sex, diabetes, or BMI. This association held in multivariate analyses also after correction for confounding factors, including other adiposity indices (P < 0.001). When receiver operating characteristic curves were built to detect a eGFR < 60 mL/minutes per 1.73 m , a PUFT value ≤3.725 cm showed a negative predictive value of 94.0%, with the largest area under the curve (AUC: 0.700) among the variables considered. In conclusion, the relationship between PUFT and GFR seems to be more accurate and less influenced by the bias affecting traditional indices of adiposity.

show abstract

“…3 Indeed, the perirenal fat thickness has emerged as an independent predictor of renal dysfunction in patients with diabetes, 4 and renal sinus fat has been associated with poor blood pressure control. 5 However, while perirenal fat may be associated with renal vascular or parenchymal disorders, 6 its precise role remains unknown.…”

Section: Introductionmentioning

confidence: 99%

Perirenal Fat Promotes Renal Arterial Endothelial Dysfunction in Obese Swine through Tumor Necrosis Factor-α

Zhu

Eirin

et al. 2016

Journal of Urology

View full text Add to dashboard Cite

Purpose Perirenal fat is associated with poor blood pressure control and chronic kidney disease, but the underlying mechanisms remain elusive. We tested the hypothesis that perirenal fat impairs renal arterial endothelial function in pigs with obesity-metabolic derangements (ObM). Material and Methods Fourteen domestic pigs were studied after 16 weeks of a high-fat/high-fructose diet (ObM) or standard chow (Lean). Renal blood flow (RBF), glomerular filtration rate (GFR), and visceral fat volumes were studied in-vivo with CT. Renal arterial endothelial function was also studied ex-vivo in the organ bath. Results ObM pigs demonstrated increased body weight, blood pressure, cholesterol, and intra-abdominal fat compared to lean pigs, and perirenal fat volume was significantly larger. RBF and GFR were markedly elevated, while urinary protein level was preserved. Ex-vivo acetylcholine-induced endothelium-dependent vasodilation of renal artery rings was substantially impaired in ObM compared to Lean. Endothelial function was further blunted in both ObM and Lean arterial rings by incubation with perirenal fat harvested from ObM, but not from Lean pigs, and was restored by inhibition of tumor necrosis factor (TNF)-α. ObM perirenal fat also showed increased pro-inflammatory macrophage infiltration and TNF-α expression. Conclusions ObM perirenal fat directly causes renal artery endothelial dysfunction, partly mediated by TNF-α.

show abstract

Sonographic evaluation of para- and perirenal fat thickness is an independent predictor of early kidney damage in obese patients

Abstract: PFUT may be an independent predictor of early kidney damage in nonhypertensive, nondiabetic obese patients, and PFUT could be a useful tool for the assessment of visceral fat and early kidney damage in obese patients.

Cited by 41 publications

References 22 publications

Induction of Haemeoxygenase-1 Directly Improves Endothelial Function in Isolated Aortas from Obese Rats through the Ampk-Pi3k/Akt-Enos Pathway

Induction of Haemeoxygenase-1 Directly Improves Endothelial Function in Isolated Aortas from Obese Rats through the Ampk-Pi3k/Akt-Enos Pathway

Para‐perirenal distribution of body fat is associated with reduced glomerular filtration rate regardless of other indices of adiposity in hypertensive patients

Perirenal Fat Promotes Renal Arterial Endothelial Dysfunction in Obese Swine through Tumor Necrosis Factor-α

Contact Info

Product

Resources

About