Sonographic diagnosis of a subdural hematoma as the initial manifestation of hemophilia in a newborn.

Franze, I; Forrest, T S

doi:10.7863/jum.1988.7.3.149

Cited by 8 publications

(3 citation statements)

References 6 publications

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“…In der Neonatalperiode wurden mehrfach Kasuistiken über intrakranielle Blutungen bei Hämophilie berichtet, die sich jedoch fast alle auf die 1. Lebenswoche beschränken (2,3,4,5,6,8,11,12,15,18,19,24,26,28,29,31,37,40). In der späten Neonatalperiode (2. im Neugeborenen-und Säuglingsalter wurden nicht in allen Mitteilungen die exakten Blutungslokalisationen beschrieben, allerdings dürfte der Prozentsatz der subduralen Blutungen in dieser Altersgruppe sogar eher etwas höher liegen.…”

Section: Abstract Hemophilia -Subdural Hematoma -Newbornsunclassified

“…In der späten Neonatalperiode (2. im Neugeborenen-und Säuglingsalter wurden nicht in allen Mitteilungen die exakten Blutungslokalisationen beschrieben, allerdings dürfte der Prozentsatz der subduralen Blutungen in dieser Altersgruppe sogar eher etwas höher liegen. Auch das isolierte Auftreten eines Subduralhämatoms ohne andere zusätzliche intrakranielle Blutungslokalisationen ist in dieser Altersgruppe nicht selten (2,4,11,31,37,40 einer Hämophilie bereits unmittelbar postpartal möglich ist. Da insbesondere subdurale Hämatome eine prolongierte klinische Symptomatik bieten können, sollte eine unklare Anämie und/oder Hyperbilirubinämie, auch bei fehlenden neurologischen Auffälligkeiten, auf das Vorliegen einer intrakraniellen Blutung untersucht werden.…”

Section: Abstract Hemophilia -Subdural Hematoma -Newbornsunclassified

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Spontanes Subduralhämatom bei einem 18 Tage alten männlichen Neugeborenen mit schwerer Hämophilie A

Ries¹,

Klinge²,

Rauch³

et al. 1998

Klin Padiatr

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Most intracranial bleedings in hemophiliacs occur in patients more than 6 months of age. In the neonatal period, this complication is rare and almost always observed in the first week of life. Based on a review of the literature, intracranial hemorrhage is an exceedingly rare occurrence in infants with hemophilia aged 2 weeks-6 months. We report on a male infant with hemophilia A who was referred to our hospital on day 18 because of pallor and jaundice. The neurological examination was normal. A cerebral ultrasound showed a left sided subdural hematoma with a shift of the midline structures to the right. Packed red blood cells (10 ml/kg) and factor VIII replacement (250 IU) were rapidly instituted and a craniotomy with evacuation of the hematoma was performed. The postoperative course was uneventful. On discharge, the neurological examination was considered normal.

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Section: Abstract Hemophilia -Subdural Hematoma -Newbornsunclassified

Spontanes Subduralhämatom bei einem 18 Tage alten männlichen Neugeborenen mit schwerer Hämophilie A

Ries¹,

Klinge²,

Rauch³

et al. 1998

Klin Padiatr

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“…There are 16 cases of intracerebral hemorrhage in term neonates as a presenting manifestation of hemophilia reported in the literature [5, 8, 9, 11, 12, 13, 14, 15, 16]. Four of these cases presented with acute subdural hematoma.…”

Section: Introductionmentioning

confidence: 99%

Intracranial Hemorrhage in Neonates with Unrecognized Hemophilia A: A Persisting Problem

Myles¹,

Massicotte

Drake³

2001

Pediatr Neurosurg

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Hemophilia is a rare disorder, and an uncommon cause of intracranial hemorrhage in neonates. We present 2 patients with hemophilia A, who presented with massive subdural hemorrhages on day 5 and day 4 postpartum. Both were taken urgently to surgery without a diagnosis of hemophilia being established. Neither patient had a family history of hemophilia, and both were born following difficult deliveries. The activated partial thromboplastin time (APTT) was normal in patient No. 1 (subsequent factor VIII level 10%). In patient No. 2, the APTT was slightly prolonged, but initially interpreted as being within the normal range for age (subsequent factor VII level of <1%). Patient 1 rebled, required a second operation, and had a poor outcome. Patient 2 was given prophylactic fresh frozen plasma, and made a good recovery. Factor VIII assay should be performed in all term male babies presenting with intracranial hemorrhage. In urgent circumstances, prophylactic clotting therapy should be administered during surgery to prevent postoperative bleeding in an undiagnosed hemophiliac.

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Initial Presentations of Pediatric Hemophiliacs

Conway¹

1994

Arch Pediatr Adolesc Med

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Sonographic diagnosis of a subdural hematoma as the initial manifestation of hemophilia in a newborn.

Cited by 8 publications

References 6 publications

Spontanes Subduralhämatom bei einem 18 Tage alten männlichen Neugeborenen mit schwerer Hämophilie A

Spontanes Subduralhämatom bei einem 18 Tage alten männlichen Neugeborenen mit schwerer Hämophilie A

Intracranial Hemorrhage in Neonates with Unrecognized Hemophilia A: A Persisting Problem

Initial Presentations of Pediatric Hemophiliacs

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