2008
DOI: 10.1179/174313408x320914
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Sonographic Characterisation of Tissue Changes Associated with Infused Apomorphine Hydrochloride: A Case Series

Abstract: Apomorphine hydrochloride is used to treat refractory motor fluctuations in advanced Parkinson's disease. Delivery by infusion is associated with the formation of hard subcutaneous nodules, which may be painful, limit available infusion sites, and interfere with absorption of the drug. Diagnostic ultrasound was used to image affected tissue in 12 people experiencing apomorphine nodule formations. It revealed significant departures from normality in dermal and subcutaneous tissue, including a variety of nodule … Show more

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Cited by 2 publications
(1 citation statement)
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“…Preliminary investigations by our group demonstrated significant differences in hardness, tenderness, and sonographic appearance of tissue used for apomorphine infusion, when compared with normal tissue (data available from corresponding author). Sonographic changes included focal variations in echogenicity corresponding to palpable nodules, dermal thickening, and diffuse oedematous changes in the adipose tissue 17. Pre‐ and post‐treatment images were compared to identify the extent of change in these variables, using a scoring system in which shrinkage of nodules and normalization of dermal thickness and echogenicity were quantified.…”
Section: Methodsmentioning
confidence: 99%
“…Preliminary investigations by our group demonstrated significant differences in hardness, tenderness, and sonographic appearance of tissue used for apomorphine infusion, when compared with normal tissue (data available from corresponding author). Sonographic changes included focal variations in echogenicity corresponding to palpable nodules, dermal thickening, and diffuse oedematous changes in the adipose tissue 17. Pre‐ and post‐treatment images were compared to identify the extent of change in these variables, using a scoring system in which shrinkage of nodules and normalization of dermal thickness and echogenicity were quantified.…”
Section: Methodsmentioning
confidence: 99%