Tetracycline is named by its four special benzene rings in molecular structure, which has been proven as a strong inhibition chemical for many kinds of bacterial. To solve the problem of residual tetracycline containing in municipal and medicine industrial wastewater effluents, this study tried to combine the ultrasound with transition metals ( .9% of tetracycline were degraded and mineralized. In addition, the toxicity was significantly reduced while the cell viability increased from 53.1% (un-treated) to 87.5% (treated). Effect of pH on the degradation of tetracycline in this study was insignificant but pH 3 showed the better efficiency. It was concluded that the enhanced sonolysis was effective on the degradation, mineralization and detoxicity of tetracycline solution.