Sonoelastography to Assess Muscular Stiffness Among Older Adults and its Use for the Diagnosis of Sarcopenia: A Systematic Review

Janczyk, Ewa Magdalena; Champigny, Noémie; Michel, Émeline; Raffaelli, Charles; Annweiler, Cédric; Zory, Raphaël; Guérin, Olivier; Sacco, Guillaume

doi:10.1055/a-1293-8057

Cited by 9 publications

(8 citation statements)

References 36 publications

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“…Fourth, we only included English publications, which may have resulted in selection bias. Fifth, some new ultrasound parameters, such as pennation angle, muscle contraction potential and muscle microcirculation, have been associated with sarcopenia 13,46,47 . However, the included studies in our review did not address these parameters.…”

Section: Discussionmentioning

confidence: 96%

“…Fifth, some new ultrasound parameters, such as pennation angle, muscle contraction potential and muscle microcirculation, have been associated with sarcopenia. 13 , 46 , 47 However, the included studies in our review did not address these parameters. Finally, some new ultrasound technologies, such as panoramic ultrasound imaging 48 and ultrasonic elastography, 47 have been applied in sarcopenia research, but our review did not include relevant studies.…”

Section: Discussionmentioning

confidence: 99%

“…So far, six systematic reviews have addressed the use of ultrasound for measuring skeletal muscle. 6,[10][11][12][13][14] One of these reviews reported the validity of ultrasound-based models for predicting whole-body muscle mass, 11 one examined the reliability of sonoelastography to assess sarcopenia, 13 two summarized the techniques used for muscle measurement using ultrasound in sarcopenia 12,14 and the other two evaluated the validity and reliability of detecting muscle mass in older adults. 6,10 Measurable diagnostic properties including sensitivity and specificity are essential for clinicians and researchers to evaluate and choose an optimal diagnostic tool.…”

Section: Introductionmentioning

confidence: 99%

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Diagnostic test accuracy of ultrasound for sarcopenia diagnosis: A systematic review and meta‐analysis

Wang

Zhang

et al. 2022

J cachexia sarcopenia muscle

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Muscle ultrasound is an emerging tool for diagnosing sarcopenia. This review aims to summarize the current knowledge on the diagnostic test accuracy of ultrasound for the diagnosis of sarcopenia. We collected data from Ovid Medline, Embase and the Cochrane Central Register of Controlled Trials. Diagnostic test accuracy studies using muscle ultrasound to detect sarcopenia were included. Bivariate random‐effects models based on sensitivity and specificity pairs were used to calculate the pooled estimates of sensitivity, specificity and the area under the curves (AUCs) of summary receiver operating characteristic (SROC), if possible. We screened 7332 publications and included 17 studies with 2143 participants (mean age range: 52.6–82.8 years). All included studies had a high risk of bias. The study populations, reference standards and ultrasound measurement methods varied across the studies. Lower extremity muscles were commonly studied, whereas muscle thickness (MT) was the most widely measured parameter, followed by the cross‐sectional area (CSA). The MTs of the gastrocnemius, rectus femoris, tibialis anterior, soleus, rectus abdominis and geniohyoid muscles showed a moderate diagnostic accuracy for sarcopenia (SROC‐AUC 0.83, 8 studies; SROC‐AUC 0.78, 5 studies; AUC 0.82, 1 study; AUC 0.76–0.78, 2 studies; AUC 0.76, 1 study; and AUC 0.79, 1 study, respectively), whereas the MTs of vastus intermedius, quadriceps femoris and transversus abdominis muscles showed a low diagnostic accuracy (AUC 0.67–0.71, 3 studies; SROC‐AUC 0.64, 4 studies; and AUC 0.68, 1 study, respectively). The CSA of rectus femoris, biceps brachii muscles and gastrocnemius fascicle length also showed a moderate diagnostic accuracy (AUC 0.70–0.90, 3 studies; 0.81, 1 study; and 0.78–0.80, 1 study, respectively), whereas the echo intensity (EI) of rectus femoris, vastus intermedius, quadriceps femoris and biceps brachii muscles showed a low diagnostic accuracy (AUC 0.52–0.67, 2 studies; 0.48–0.50, 1 study; 0.43–0.49, 1 study; and 0.69, 1 study, respectively). The combination of CSA and EI of biceps brachii or rectus femoris muscles was better than either CSA or EI alone for diagnosing sarcopenia. Muscle ultrasound shows a low‐to‐moderate diagnostic test accuracy for sarcopenia diagnosis depending on different ultrasound parameters, measured muscles, reference standards and study populations. The combination of muscle quality indicators (e.g., EI) and muscle quantity indicators (e.g., MT) might provide better diagnostic test accuracy.

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Section: Discussionmentioning

confidence: 96%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Diagnostic test accuracy of ultrasound for sarcopenia diagnosis: A systematic review and meta‐analysis

Wang

Zhang

et al. 2022

J cachexia sarcopenia muscle

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“…Recently, EBUS elastography has been widely applied in the diagnosis of breast cancer, prostate cancer, liver disease, myopathies etc. (Berzigotti 2017;Janczyk et al 2020;Kapetas et al 2019;Wildeboer et al 2020).…”

Section: Discussionmentioning

confidence: 99%

Diagnostic value of endobronchial ultrasound elastography combined with rapid onsite cytological evaluation in endobronchial ultrasound-guided transbronchial needle aspiration

Huang¹,

Lü²,

Wang³

et al. 2021

Preprint

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Background: Endobronchial ultrasound (EBUS) elastography has been applied in EBUS-guided transbronchial needle aspiration (EBUS-TBNA) to identify malignant lymph nodes based on the tissue stiffness. Rapid onsite cytological evaluation (ROSE) has been widely used for onsite evaluation of the adequacy of the samples and guiding the sampling during EBUS-TBNA. The aim of the study is to investigate the diagnostic value of combined EBUS elastography and ROSE in evaluating of mediastinal and hilar lymph nodes status.Methods: A retrospective chart review was performed from December 2018 to September 2020. Patients’ demographic, EBUS elastography score, ROSE, pathologic and clinical outcomes were collected. The EBUS elastography scores were classified as follows: Type 1, predominantly non-blue; Type 2, partially blue and partially non-blue; Type 3, predominantly blue. Receiver operating characteristic (ROC) curve was used to compare the sensitivity, specificity, positive predictive value, negative predictive value, positive likelihood ratio, and negative likelihood ratio among EBUS elastography, ROSE, and EBUS combined with ROSE groups for evaluation of malignant lymph nodes.Results: A total of 247 patients (345 lymph nodes) were included in our study. The sensitivity and specificity of EBUS elastography group in the diagnosis of malignant lymph nodes were 90.51% and 57.26%, respectively. The sensitivity and specificity in the ROSE alone group were 96.32% and 79.05%, respectively. The sensitivity, specificity, positive likelihood ratio, and negative likelihood ratio of EBUS elastography combined with ROSE group were 86.61%, 92.65%, 11.78, and 0.14, respectively, and the area under curve was 0.942.Conclusions: The combination of EBUS elastography and ROSE significantly increased the diagnostic value of EBUS-TBNA in evaluating mediastinal and hilar lymph nodes status.

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“…CT and MRI are the gold standards for non‐invasive evaluation of muscle mass and quantity 9 . However, MRI and CT are not frequently employed in primary medical institutions due to the high equipment cost and lack of mobility 4,10 . As of yet, there is no consensus on cut‐off points for sarcopenia in daily clinical settings 7,11 …”

Section: Introductionmentioning

confidence: 99%

A Multivariable Model Based on Ultrasound Imaging Features of Gastrocnemius Muscle to Identify Patients With Sarcopenia

Chen

Cai

et al. 2023

J of Ultrasound Medicine

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ObjectivesLow skeletal muscle mass, strength, or somatic function are used to diagnose sarcopenia; however, effective assessment methods are still lacking. Therefore, we evaluated the effectiveness of ultrasound in identifying patients with sarcopenia.MethodsThis study included 167 patients, 78 with sarcopenia and 89 healthy participants, from two hospitals. We evaluated clinical factors and five ultrasound imaging features, of which three ultrasound imaging features were used to create the model. In both the training and validation datasets, the sarcopenia detection performances of chosen ultrasonic characteristics and the constructed model were evaluated using receiver operating characteristic (ROC) curves. The predictive performance was evaluated by area under the ROC (AUROC), calibration, and decision curves.ResultsThere were statistically significant differences in muscle thickness (MT) of gastrocnemius medialis muscle (GM), flaky myosteatosis echo (FE), pennation angle (PA), average shear wave velocity (SWV) in the relaxed state (RASWV), and average SWV in the passive stretched state (PASWV) between sarcopenic and normal subjects. PA, RASWV, and PASWV were effective predictors of sarcopenia. The AUROC (95% confidence interval) for these three parameters were 0.930 (0.882–0.978), 0.865 (0.791–0.940), and 0.849 (0.770–0.928), respectively, in the training set, and 0.873 (0.777–0.969), 0.936 (0.878–0.993), and 0.826 (0.716–0.935), respectively, in the validation set. The combined model had better detection power. Finally, the calibration curve showed that the combined model had good prediction accuracy.ConclusionOur model can be used to identify sarcopenia in primary medical institutions, which is valuable for the early recognition and management of sarcopenia patients.

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Sonoelastography to Assess Muscular Stiffness Among Older Adults and its Use for the Diagnosis of Sarcopenia: A Systematic Review

Cited by 9 publications

References 36 publications

Diagnostic test accuracy of ultrasound for sarcopenia diagnosis: A systematic review and meta‐analysis

Diagnostic test accuracy of ultrasound for sarcopenia diagnosis: A systematic review and meta‐analysis

Diagnostic value of endobronchial ultrasound elastography combined with rapid onsite cytological evaluation in endobronchial ultrasound-guided transbronchial needle aspiration

A Multivariable Model Based on Ultrasound Imaging Features of Gastrocnemius Muscle to Identify Patients With Sarcopenia

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