Sonodynamic therapy: Ultrasound parameters and in vitro experimental configurations

Martins, Yugo Araújo; Pavan, Theo Z.; Lopez, Renata Fonseca Vianna

doi:10.1016/j.ijpharm.2021.121243

Cited by 35 publications

(26 citation statements)

References 123 publications

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“…With remarkable advancements in nanotechnology, nanomaterials have been introduced as an alternative route to overcome the above issues of traditional sonosensitizers and increasing number of nano-sonosensitizers have been designed and widely used recently ( Guo et al, 2022 ). As for ultrasound, studies mainly concentrated on ultrasound setting parameters including frequency, intensity, transducer geometry, coupling media, as well as other experimental conditions that could affect reproducibility and transferability ( Secomski et al, 2017 ; Araújo Martins et al, 2021 ; Tamboia et al, 2022 ). However, to our knowledge, the ultrasound parameters in different laboratories are still not fully standardized.…”

Section: Discussionmentioning

confidence: 99%

Mapping knowledge landscapes and emerging trends of sonodynamic therapy: A bibliometric and visualized study

Cheng

Shen

et al. 2023

Front. Pharmacol.

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Background: Ultrasound-triggered sonodynamic therapy (SDT), as a non-invasive approach, has attracted considerable attention in a wide variety of malignant tumors and other diseases. Over the past 2 decades, the number of scientific publications on SDT has increased rapidly. However, there is still a lack of one comprehensive report that summarizes the global research trends and knowledge landscapes in the field of SDT in detail. Thus, we performed a bibliometric analysis on SDT from 2000 to 2021 to track the current hotspots and highlight future directions.Methods: We collected publications on SDT research from the Web of Science Core Collection database. The annual number of publications and citations, major contributors, popular journals, international collaborations, co-cited references and co-occurrence keywords were analyzed and visualized with CiteSpace, VOSviewer, and R-bibliometrix.Results: A total of 701 publications were included. The annual publication output increased from 5 in 2000 to 175 in 2021, and the average growth rate was 18.4%. China was the most productive country with 463 documents (66.05%), and Harbin Medical University was the most prolific institution (N = 73). Ultrasound in Medicine and Biology published the most papers related to SDT. Materials Science, and Chemistry were the research areas receiving the most interest. All the keywords were divided into four different clusters including studies on mechanisms, studies on drug delivery and nanoparticles, studies on cancer therapy, as well as studies on ultrasound and sonosensitizers. In addition to nanomaterials-related studies including nanoparticles, mesoporous silica nanoparticles, nanosheets, liposomes, microbubble and TiO2 nanoparticle, the following research directions such as immunogenic cell death, metal-organic framework, photothermal therapy, hypoxia, tumor microenvironment, chemodynamic therapy, combination therapy, tumor resistance, intensity focused ultrasound, drug delivery, and Staphylococcus aureus also deserve further attention and may continue to explode in the future.Conclusion: SDT has a bright future in the field of cancer treatment, and nanomaterials have increasingly influenced the SDT field with the development of nano-technology. Overall, this comprehensive bibliometric study was the first attempt to analyze the field of SDT, which could provide valuable references for later researchers to better understand the global research trends, hotspots and frontiers in this domain.

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Section: Discussionmentioning

confidence: 99%

Mapping knowledge landscapes and emerging trends of sonodynamic therapy: A bibliometric and visualized study

Cheng

Shen

et al. 2023

Front. Pharmacol.

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“…At present, 0.15-2.0 MHz ultrasound is generally used during SDT. The normal irradiation amount is 2-3 W/cm 2 for 60 s-30 min ( 29 ). High-frequency ultrasound with high ultrasound intensity can produce a thermal effect and directly kill cells.…”

Section: Discussionmentioning

confidence: 99%

Microbubbles Ultrasonic Cavitation Regulates Tumor Interstitial Fluid Pressure and Enhances Sonodynamic Therapy

Feng

Chen

et al. 2022

Front. Oncol.

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Sonodynamic therapy (SDT) is a promising treatment method for solid tumors. However, the high interstitial fluid pressure (IFP) in tumor tissues limits the accumulation of sonosensitizers. In the present study, microbubbles ultrasonic cavitation was used to regulate the tumor’s IFP and evaluate SDT effects. Rabbit VX2 tumor tissues were treated with microbubbles ultrasonic cavitation. The IFP of different tumor parts before and after cavitation was measured by the WIN method. The accumulation of the sonosensitizers hematoporphyrin monomethyl ether (HMME) in tumor tissues was observed using an ultramicro spectrophotometer and laser confocal microscope. Then, tumor-bearing rabbits were treated with SDT once a week for eight weeks and the therapeutic effect was evaluated. After microbubbles ultrasonic cavitation treatment, the tumor’s IFP decreased and the HMME concentration increased. We concluded that microbubbles ultrasonic cavitation can increase HMME accumulation in rabbit VX2 tumors and increase SDT therapeutic effects.

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“…21 Nevertheless, the mechanical effect is rarely considered when assessing biochemical effects derived from SDT, and the sonochemical effects are the most discussed. 22…”

Section: Mechanisms Of Sdtmentioning

confidence: 99%

Nanomaterial-based sonosensitizers: from exemplary design towards purposeful improvement

Liu

Yang

et al. 2023

Mater. Chem. Front.

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Sonodynamic therapy: Ultrasound parameters and in vitro experimental configurations

Cited by 35 publications

References 123 publications

Mapping knowledge landscapes and emerging trends of sonodynamic therapy: A bibliometric and visualized study

Mapping knowledge landscapes and emerging trends of sonodynamic therapy: A bibliometric and visualized study

Microbubbles Ultrasonic Cavitation Regulates Tumor Interstitial Fluid Pressure and Enhances Sonodynamic Therapy

Nanomaterial-based sonosensitizers: from exemplary design towards purposeful improvement

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