Sonodynamic therapy of pancreatic cancer cells based on synergistic chemotherapeutic effects of selenium-PEG-curcumin nanoparticles and gemcitabine

Ilbeigi, Shahrzad; Ranjbar, Aliyeh; Zahraie, N.; Vais, R. Dehdari; Monjezi, M. Rafiee; Sattarahmady, N.

doi:10.1007/s00339-022-06377-0

Cited by 5 publications

(4 citation statements)

References 63 publications

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“…Macrophages incubated with curcumin and exposed to ultrasound irradiation experience an interaction between activated curcumin and molecular oxygen, producing cytotoxic ROS, especially singlet oxygen, which ultimately leads to cell death [42,[52][53][54][55]. Wang F. et al investigated the sonodynamic effect of curcumin on THP-1-derived macrophages using slightly different parameters than our study [17].…”

Section: Discussionmentioning

confidence: 85%

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Synergizing Immune Balance: Curcumin Gold Nanoparticles and Ultrasound Irradiation for Macrophage Down-Regulation

Teixeira,

Gonçalves,

Vieira

et al. 2024

AppliedChem

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The multifaceted health benefits of curcumin (Curcuma longa), attributed to its antioxidant, antitumor, and anti-inflammatory activities, have drawn significant scientific attention. Curcumin shows promise as a potential modulator of macrophage polarization, offering a natural strategy for managing inflammation and promoting tissue repair. However, a limiting factor for this beneficial molecule is its limited bioavailability due to its low solubility in water. This study aimed to quantify the effect of curcumin gold nanoparticle (CurAuNP)-mediated ultrasound irradiation on THP-1-derived macrophages as potential therapeutic targets. The photoreduction method was applied to synthesize the gold nanoparticles with curcumin as a ligand (CurAu). The effect of adding polyethylene glycol in the synthesis process was studied (CurAuPEG). CurAuNP characterization included UV/Vis, Zeta potential, transmission electron microscopy, and FTIR. The amount of singlet oxygen released by curcumin and CurAuNPs was quantified by observing 1.3-diphenylisobenzofuran quenching upon ultrasound irradiation (1 MHz and 1 W/cm2). The results indicated that ultrasound therapy for 4 min with CurAuNPs significantly enhanced singlet oxygen generation and reduced macrophage viability compared to curcumin alone. The increased sonoluminescence and curcumin delivery facilitated by CurAuNPs led to greater curcumin activation. Consequently, CurAuNPs could offer promising therapeutic options for modulating macrophage polarization in pro-inflammatory and anti-inflammatory stages.

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Section: Discussionmentioning

confidence: 85%

“…The combined effect of these factors can facilitate curcumin delivery, significantly enhancing its effectiveness while minimizing side effects [40,41]. Several reports indicate the dual role of curcumin-based nanoparticles in photothermal (PTT) and SDT therapies [24,42].…”

Section: Introductionmentioning

confidence: 99%

Synergizing Immune Balance: Curcumin Gold Nanoparticles and Ultrasound Irradiation for Macrophage Down-Regulation

Teixeira,

Gonçalves,

Vieira

et al. 2024

AppliedChem

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“…However, accumulation under physiological conditions and elimination from circulation lead to formation of less ROS and ultimately decreased therapeutic efficacy [10] , [12] . Nowadays, the emergence of nanotechnology has led to the development of nanoparticles (NPs)-based acoustic sensitizers [13] , [14] , [15] , [16] , [17] , [18] . It has been demonstrated that the presence of NPs amplifies the cavitation effects and improves their efficiency by lowering the cavitation threshold [13] , [14] .…”

Section: Introductionmentioning

confidence: 99%

An amplified sonodynamic therapy by a nanohybrid of titanium dioxide-gold-polyethylene glycol-curcumin: HeLa cancer cells treatment in 2D monolayer and 3D spheroid models

Haghighi,

Zahraie,

Haghani

et al. 2024

Ultrasonics Sonochemistry

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“…Targeted, photothermal, photodynamic, sonodynamic, radiation-chemo, and stem cell therapy are among the new routes of cancer treatment. Nanomedicine has introduced novel treatment approaches and represented solutions for challenges in cancer medicine [2][3][4][5][6][7][8][9].…”

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confidence: 99%

Characterization and Evaluation of Nano-niosomes Encapsulating Docetaxel against Human Breast, Pancreatic, and Pulmonary Adenocarcinoma Cancer Cell Lines

2024

J Biomed Phys Eng

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Background: Docetaxel (DXL) is an antineoplastic agent for cancer treatment, the therapeutic efficiency of which is limited due to low solubility, hydrophobicity, and tissue specificity. Objective: In this study, nano-niosomes were introduced for improving therapeutic index of DXL. Material and Methods: In this experimental study, two nano-niosomes were synthesized using Span 20® and Span 80® and a thin film hydration method with DXL loading (DXL-Span20 and DXL-Span80). Characterization, in-vitro cytotoxicity and bioavailability of the nano-niosomes was also evaluated via in-vivo experiments. Results: DXL-Span20 and DXL-Span80 have vesicles size in a range of 84-90 nm and negative zeta potentials. DXL entrapment efficiencies were obtained as 69.6 and 74.0% for DXL-Span20 and DXL-Span80, respectively; with an in-vitro sustained release patterns. Cytotoxicity assays were performed against MDA-MB-231, Calu-6, and AsPC-1 cell lines, and the results indicated that DXL loading into nano-niosomes led to decrement in values of half-maximal inhibitory concentration (IC50) at least 2.5 times and at most 6.5 times, compared to free DXL. Moreover, the rat blood bioavailability of DXL after intraperitoneal administration and the pharmacokinetic parameters indicated higher DXL plasma level and the higher effectiveness of DXL-Span80 compared to DXL-Span20. Conclusion: Carrying DXL by the nano-niosomes led to enhanced cytotoxicity (and lower IC50 values) and higher efficacy with enhanced pharmacokinetic parameters.

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Sonodynamic therapy of pancreatic cancer cells based on synergistic chemotherapeutic effects of selenium-PEG-curcumin nanoparticles and gemcitabine

Cited by 5 publications

References 63 publications

Synergizing Immune Balance: Curcumin Gold Nanoparticles and Ultrasound Irradiation for Macrophage Down-Regulation

Synergizing Immune Balance: Curcumin Gold Nanoparticles and Ultrasound Irradiation for Macrophage Down-Regulation

An amplified sonodynamic therapy by a nanohybrid of titanium dioxide-gold-polyethylene glycol-curcumin: HeLa cancer cells treatment in 2D monolayer and 3D spheroid models

Characterization and Evaluation of Nano-niosomes Encapsulating Docetaxel against Human Breast, Pancreatic, and Pulmonary Adenocarcinoma Cancer Cell Lines

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