Sonodynamic therapy for breast cancer: A literature review

Zhou, Haiying; Chen, Yi; Li, Ping; He, Xiaohai; Zhong, Jieyu; Hu, Ziqiang; Liu, Li; Chen, Yun; Cui, Guanghui; Sun, Desheng; Zheng, Tingting

doi:10.1515/chem-2022-0186

Cited by 2 publications

(1 citation statement)

References 57 publications

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“…Another practical approach is son dynamic therapy (SDT), a novel noninvasive treatment that uses acoustic sensitizers and low-intensity ultrasound. [35,36] CaO 2 NPcontaining sonosensitizers release ROS when sound waves trigger, ultimately killing tumor cells. [37] Furthermore, glucose or lactic acid deprivation-based cancer starvation therapy (ST) is another practical approach to inhibit tumor growth.…”

Section: Introductionmentioning

confidence: 99%

Composite Nanoplatforms Based on Nanocalcium Peroxide for Cancer Treatment: From Monotherapy to Combination Therapy

Liu

Wang

et al. 2023

Advanced Therapeutics

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Nano‐CaO2, with its multifunctional properties, has emerged as a promising candidate for tumor therapy. Its ability to release Ca2+ and H2O2 into the tumor microenvironment has positively modulated abnormal calcium signaling and kinetic therapy. Moreover, the indirectly produced O22− by CaO2 can alleviate hypoxic conditions. On the one hand, the accumulation of Ca2+ can lead to various tumor cell apoptosis events, such as calcium overload and tumor calcification. On the other hand, the released H2O2 can convert into more toxic reactive oxygen species (ROS) via exogenous stimulation and endogenous regulation, thereby making nano‐CaO2 a versatile tool in modern medicine, exhibiting its invaluable and irreplaceable medical value in tumor therapy. Hence, a comprehensive review of the recent advances in the nano‐CaO2 platform is imperative. This review provides an overview of the conventional synthesis strategies for nano‐CaO2. It elucidates the potential role of the nano‐CaO2 nanoplatforms in various tumor treatment strategies, including monotherapy and combination therapy, in detail. Given the remarkable outcomes achieved to date and the challenges that of future clinical translation, this work predicts the future research directions. This review will encourage further development of the metal oxide nanomedicine family, epitomized by nano‐CaO2.

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Section: Introductionmentioning

confidence: 99%

Composite Nanoplatforms Based on Nanocalcium Peroxide for Cancer Treatment: From Monotherapy to Combination Therapy

Liu

Wang

et al. 2023

Advanced Therapeutics

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Recent Developments of Inorganic Nanosensitizers for Sonodynamic Therapy

Miao

et al. 2023

Adv Healthcare Materials

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As a noninvasive treatment, sonodynamic therapy (SDT) has been widely used in the treatment of tumors because of its ability to penetrate deep tissue with few side effects. As the key factor of SDT, it is meaningful to design and synthesize efficient sonosensitizers. Compared with organic sonosensitizers, inorganic sonosensitizers can be easily excited by ultrasound. In addition, inorganic sonosensitizers with stable properties, good dispersion, and long blood circulation time, have great development potential in SDT. This review summarizes possible mechanisms of SDT (sonoexcitation and ultrasonic cavitation) in detail. Based on these mechanisms, the design and synthesis of inorganic nanosonosensitizers can be divided into three categories: traditional inorganic semiconductor sonosensitizers, enhanced inorganic semiconductor sonosensitizers, and cavitation‐enhanced sonosensitizers. Subsequently, the current efficient construction methods of sonosensitizers are summarized including accelerated semiconductor charge separation and enhanced production of reactive oxygen species through ultrasonic cavitation. Furthermore, the advantages and disadvantages of different inorganic sonosensitizers and detailed strategies are systematically discussed on how to enhance SDT. Hopefully, this review could provide new insights into the design and synthesis of efficient inorganic nano‐sonosensitizers for SDT.

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Sonodynamic therapy for breast cancer: A literature review

Cited by 2 publications

References 57 publications

Composite Nanoplatforms Based on Nanocalcium Peroxide for Cancer Treatment: From Monotherapy to Combination Therapy

Composite Nanoplatforms Based on Nanocalcium Peroxide for Cancer Treatment: From Monotherapy to Combination Therapy

Recent Developments of Inorganic Nanosensitizers for Sonodynamic Therapy

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