Sonodynamic therapy‐assisted immunotherapy: A novel modality for cancer treatment

Abstract

Sonodynamic therapy (SDT), which is based on photodynamic therapy (PDT), is a new cancer treatment modality. Unlike PDT, which has poor tissue penetration, ultrasound can penetrate deeply into tissues and largely target tumor tissue to mediate the cytotoxicity of sonosensitizers. We hypothesize that, similar to PDT, SDT may perform effectively as a cancer vaccine. Thus, we developed a therapeutic strategy to explore whether SDT can eliminate primary tumors, inhibit metastases, and prevent tumor relapse. In the present study, we found that HiPorfin (HPD)‐induced SDT killed tumor cells, promoted calreticulin expression on the cell surface and elicited immune responses. Meanwhile, we observed that SDT induced functional antitumor vaccination and abscopal effects in H22 tumor‐bearing mice. Furthermore, this strategy conferred an immunological memory, which could protect against tumor recurrence after the elimination of the initial tumor. These results showed important effects of SDT on immune responses.

Ultrasound‐Activated Sensitizers and Applications

“…Zhang et al. designed a novel cancer treatment strategy based on SDT‐assisted immunotherapy . The immune responses were elicited by immunotherapy .…”

“…designed a novel cancer treatment strategy based on SDT‐assisted immunotherapy . The immune responses were elicited by immunotherapy . The immune responses were elicited by the HiPorfin (HPD) induced SDT, which promoted calreticulin expression on the cell surface.…”

Sonodynamic therapy with immune modulatable two-dimensional coordination nanosheets for enhanced anti-tumor immunotherapy

“…In addition to direct killing of cancer cells, SDT could also trigger tumor-associated immunological responses in different ways. Similar to other local treatments such as phototherapy, radiotherapy and chemotherapy, SDT could release large amounts of tumor-associate antigens from the treated tumor cell residues [20][21][22][23]. Moreover, some studies reported that SDT could activate the pro-inflammatory responses, reverse the passive properties of antigen presenting cells such as dendritic cells and macrophages, and enhance the tumor infiltration of activated leukocytes [24,25].…”

Ultraschallaktivierte Sensibilisatoren

“…Zhang et al. entwarfen eine neuartige Strategie in der Krebstherapie basierend auf SDT‐gestützter Immuntherapie . Die Immunantworten wurden durch die Immuntherapie hervorgerufen .…”

“…entwarfen eine neuartige Strategie in der Krebstherapie basierend auf SDT‐gestützter Immuntherapie . Die Immunantworten wurden durch die Immuntherapie hervorgerufen . Die Immunantworten wurden durch eine HiPorfin(HPD)‐induzierte SDT ausgelöst, die die Calreticulin‐Expression auf der Zelloberfläche förderte.…”