Sonochemotherapy: from bench to bedside

Lammertink, Bart; Bos, Clemens; Deckers, Roel; Storm, Gert; Moonen, Chrit; Escoffre, Jean‐Michel

doi:10.3389/fphar.2015.00138

Cited by 84 publications

(95 citation statements)

References 116 publications

(176 reference statements)

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“…They were treated using a customized configuration of commercial clinical ultrasound scanners in the presence of MBs. The combination of ultrasound, microbubbles, and the chemotherapy in these clinical settings increased the number of treatment cycles, prolonging the quality of life in patients with pancreatic adenocarcinomas compared to chemotherapy treatment alone [147,178,[186][187][188][189][190].…”

Section: Clinical Applications Of Nps Assisted Ultrasound In Cancer Tmentioning

confidence: 99%

Nanoparticle-assisted ultrasound: A special focus on sonodynamic therapy against cancer

Canavese

Ancona

Racca

et al. 2018

Chemical Engineering Journal

302

247

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• Ultrasound-based therapies are opening new horizons in the oncological field.• Innovative and promising solutions derive from different nanoparticles-assisted ultrasound treatments.• Sonodynamic therapy (SDT) emerged recently as a novel approach for cancer treatment.• Different and complex cell death mechanisms are involved in nanoparticles-assisted SDT.• Nanoparticles-assisted ultrasound is still at its infancy in clinics. A R T I C L E I N F O Keywords:Inertial cavitation Reactive oxygen species Sonoluminescence Sonodynamic Tumor Therapy Cytotoxicity A B S T R A C TAt present, ultrasound radiation is broadly employed in medicine for both diagnostic and therapeutic purposes at various frequencies and intensities. In this review article, we focus on therapeutically-active nanoparticles (NPs) when stimulated by ultrasound. We first introduce the different ultrasound-based therapies with special attention to the techniques involved in the oncological field, then we summarize the different NPs used, ranging from soft materials, like liposomes or micro/nano-bubbles, to metal and metal oxide NPs. We therefore focus on the sonodynamic therapy and on the possible working mechanisms under debate of NPs-assisted sonodynamic treatments. We support the idea that various, complex and synergistics physical-chemical processes take place during acoustic cavitation and NP activation. Different mechanisms are therefore responsible for the final cancer cell death and strongly depends not only on the type and structure of NPs or nanocarriers, but also on the way they interact with the ultrasonic pressure waves. We conclude with a brief overview of the clinical applications of the various ultrasound therapies and the related use of NPs-assisted ultrasound in clinics, showing that this very innovative and promising approach is however still at its infancy in the clinical cancer treatment.

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Section: Clinical Applications Of Nps Assisted Ultrasound In Cancer Tmentioning

confidence: 99%

Nanoparticle-assisted ultrasound: A special focus on sonodynamic therapy against cancer

Canavese

Ancona

Racca

et al. 2018

Chemical Engineering Journal

302

247

View full text Add to dashboard Cite

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“…In recent years, several concepts for ultrasound (US) mediated, targeted drug delivery have been investigated, some with quite encouraging results [7][8][9][10][11][12]. Many of the these approaches explore the use of regular US contrast microbubbles such as Sonovue™ (Bracco Imaging S.p.A, Italy) or Optison™ (GE Healthcare AS, Norway) co-injected with various drug formulations.…”

Section: Introductionmentioning

confidence: 99%

Acoustic Cluster Therapy (ACT) enhances the therapeutic efficacy of paclitaxel and Abraxane® for treatment of human prostate adenocarcinoma in mice

Wamel

Sontum

Healey

et al. 2016

Journal of Controlled Release

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Acoustic cluster therapy (ACT) is a novel approach for ultrasound mediated, targeted drug delivery. In the current study, we have investigated ACT in combination with paclitaxel and Abraxane® for treatment of a subcutaneous human prostate adenocarcinoma (PC3) in mice. In combination with paclitaxel (12 mg/kg given i.p)., ACT induced a strong increase in therapeutic efficacy; 120 days after study start, 42% of the animals were in stable, complete remission vs. 0% for the paclitaxel only group and the median survival was increased by 86%. In combination with Abraxane® (12 mg paclitaxel/kg given i.v.), ACT induced a strong increase in the therapeutic efficacy; 60 days after study start 100% of the animals were in stable, remission vs. 0% for the Abraxane® only group, 120 days after study start 67% of the animals were in stable, complete remission vs. 0% for the Abraxane® only group. For the ACT + Abraxane group 100% of the animals were alive after 120 days vs. 0% for the Abraxane® only group. Proof of concept for Acoustic Cluster Therapy has been demonstrated; ACT markedly increases the therapeutic efficacy of both paclitaxel and Abraxane® for treatment of human prostate adenocarcinoma in mice.

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“…The dimension of microbubbles also needs to be reduced to nanoscale sizes for enabling both the EPR effect and increased nanoparticle uptake via active targeting. On top of that, microbubbles and nanobubbles can be triggered using high acoustic power ultrasound for controlled drug release that enables local delivery of drugs via sonoporation . HSNs have currently been proposed as a new candidate contrast agent for CEUS imaging .…”

Section: Discussionmentioning

confidence: 99%

“…Now, the applications of CEUS imaging are widely expanded for molecular imaging, which started around 2000, and drug delivery, which started around 2005. The use of microbubbles as carriers and the controlled release profiles are achieved by sonoporation, referring to the formation of small pores (nanobubbles) after microbubble burst upon exposure to high acoustic power to release and deliver drugs or genes to targeted tissues.…”

Section: Applicationsmentioning

confidence: 99%

Atherosclerosis Treatment with Stimuli‐Responsive Nanoagents: Recent Advances and Future Perspectives

Maruf

Wang

Yin

et al. 2019

Adv Healthcare Materials

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Atherosclerosis is the root of approximately one‐third of global mortalities. Nanotechnology exhibits splendid prospects to combat atherosclerosis at the molecular level by engineering smart nanoagents with versatile functionalizations. Significant advances in nanoengineering enable nanoagents to autonomously navigate in the bloodstream, escape from biological barriers, and assemble with their nanocohort at the targeted lesion. The assembly of nanoagents with endogenous and exogenous stimuli breaks down their shells, facilitates intracellular delivery, releases their cargo to kill the corrupt cells, and gives imaging reports. All these improvements pave the way toward personalized medicine for atherosclerosis. This review systematically summarizes the recent advances in stimuli‐responsive nanoagents for atherosclerosis management and its progress in clinical trials.

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Sonochemotherapy: from bench to bedside

Cited by 84 publications

References 116 publications

Nanoparticle-assisted ultrasound: A special focus on sonodynamic therapy against cancer

Nanoparticle-assisted ultrasound: A special focus on sonodynamic therapy against cancer

Acoustic Cluster Therapy (ACT) enhances the therapeutic efficacy of paclitaxel and Abraxane® for treatment of human prostate adenocarcinoma in mice

Atherosclerosis Treatment with Stimuli‐Responsive Nanoagents: Recent Advances and Future Perspectives

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