Sonochemistry and sonoluminescence in microfluidics

Tandiono,; Ohl, Siew-Wan; Ow, Dave Siak-Wei; Klaseboer, Evert; Wong, Voon‐Kean; Dumke, Rainer; Ohl, Claus‐Dieter

doi:10.1073/pnas.1019623108

Cited by 72 publications

(71 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…25 Bright-field images and fluorescence images were captured using an attached high-speed camera and CCD camera, respectively. To determine the resonant frequencies of MMBs, we swept the driving frequencies along a certain range at a low amplifier setting.…”

Section: Oscillating Microbubbles For Nanoparticle Release Y Gao Et Almentioning

confidence: 99%

Controlled nanoparticle release from stable magnetic microbubble oscillations

Gao

Chan

et al. 2016

NPG Asia Mater

Self Cite

View full text Add to dashboard Cite

Magnetic microbubbles (MMBs) are microbubbles (MBs) coated with magnetic nanoparticles (NPs). MMBs not only maintain the acoustic properties of MBs, but also serve as an important contrast agent for magnetic resonance imaging. Such dual-modality functionality makes MMBs particularly useful for a wide range of biomedical applications, such as localized drug/gene delivery. This article reports the ability of MMBs to release their particle cargo on demand under stable oscillation. When stimulated by ultrasound at resonant frequencies, MMBs of 450 nm to 200 μm oscillate in volume and surface modes. Above an oscillation threshold, NPs are released from the MMB shell and can travel hundreds of micrometers from the surface of the bubble. The migration of NPs from MMBs can be described with a force balance model. With this technology, we deliver doxorubicincontaining poly(lactic-co-glycolic acid) particles across a physiological barrier both in vitro and in vivo, with a 18-fold and 5-fold increase in NP delivery to the heart tissue of zebrafish and tumor tissue of mouse, respectively. The penetration of released NPs in tissues is also improved. The ability to remotely control the release of NPs from MMBs suggests opportunities for targeted drug delivery through/into tissues that are not easily diffused through or penetrated. NPG Asia Materials (2016) 8, e260; doi:10.1038/am.2016.37; published online 8 April 2016 INTRODUCTIONTargeted drug delivery and controlled release is the 'holy grail' of nanomedicine. In this regard, one emerging strategy employs a localized stimulus to precisely deposit drug-containing nanoparticles (NPs) at the tissue/organ of interest. The deposited NPs then continuously release drug molecules in a localized and sustained manner. Current strategies trigger the release of NPs from carriers via enzymes, 1 magnetic fields 2 and shear stress. 3 However, these methods are limited to specific organs/tissues, such as blocked blood vessels. A more versatile technology is desired that allows the targeted delivery of NPs to any organ/tissue while maintaining traceability using a non-invasive imaging modality.The present paper reports a strategy toward this end. Magnetic microbubbles (MMBs), the combination of multi-modal contrastenhanced imaging (both magnetic resonance imaging and ultrasound imaging) with targeted drug delivery (magnetic targeting) and controlled release (bubble cavitation) at any site of interest represents an emerging theranostic platform. However, the current formulations of MMBs, stabilized by a polymeric, lipid or silica shell, need a high acoustic energy field to trigger the release through bubble

show abstract

Section: Oscillating Microbubbles For Nanoparticle Release Y Gao Et Almentioning

confidence: 99%

Controlled nanoparticle release from stable magnetic microbubble oscillations

Gao

Chan

et al. 2016

NPG Asia Mater

Self Cite

View full text Add to dashboard Cite

show abstract

“…Figure 2 shows PMT output recorded for 10 s for the three systems studied. Despite the appearance of emission spikes (common for these systems (Tandiono et al, 2011;Negishi, 1961)), the average intensity of each system was used for comparison in the following discussion.…”

Section: Resultsmentioning

confidence: 99%

“…Sonochemistry performed in microfluidic devices has received some attention in the last decade (Fernandez Rivas et al, 2010;Iida et al, 2004;Lee et al, 2007;Tandiono et al, 2011). In this work an extended study on an ultrasonic microreactor described before (Fernandez Rivas et al, 2010) is presented.…”

Section: Introductionmentioning

confidence: 93%

Sonoluminescence and sonochemiluminescence from a microreactor

Rivas

Ashokkumar

Leong

et al. 2012

Ultrasonics Sonochemistry

View full text Add to dashboard Cite

Micromachined pits on a substrate can be used to nucleate and stabilize microbubbles in a liquid exposed to an ultrasonic field. Under suitable conditions, the collapse of these bubbles can result in light emission (sonoluminescence, SL). Hydroxyl radicals (OH . ) generated during bubble collapse can react with luminol to produce light (sonochemiluminescence, SCL). SL and SCL intensities were recorded for several regimes related to the pressure amplitude (low and high acoustic power levels) at a given ultrasonic frequency (200 kHz) for pure water, and aqueous luminol and propanol solutions. Various arrangements of pits were studied, with the number of pits ranging from no pits (comparable to a classic ultrasound reactor), to three-pits. Where there was more than one pit present, in the high pressure regime the ejected microbubbles combined into linear (two-pits) or triangular (three-pits) bubble clouds (streamers). In all situations where a pit was present on the substrate, the SL was intensified and increased with the number of pits at both low and high power levels. For imaging SL emitting regions, Argon (Ar) saturated water was used under similar conditions. SL emission from aqueous propanol solution (50 mM) provided evidence of transient bubble cavitation. Solutions containing 0.1 mM luminol were also used to demonstrate the radical production by attaining the SCL emission regions.

show abstract

“…Fernandez Rivas et al [4] have enhanced the chemiluminescence of luminol by focusing acoustic cavitation inside micromachined crevices of micrometer sizes. SC of luminol and sonoluminescence of water have been reported by Tandiono et al inside PolyDiMethylSiloxane (PDMS) microchannels submitted to acoustic waves [5]. To our knowledge, only one publication has investigated correlations between chemistry and hydrodynamic cavitation in microchannels and millichannels [6].…”

Section: Introductionmentioning

confidence: 94%

Hydrodynamic Cavitation through “Labs on a Chip”: From Fundamentals to Applications

Ayela

Cherief

Colombet

et al. 2017

Oil Gas Sci. Technol. – Rev. IFP Energies nouvelles

View full text Add to dashboard Cite

-Monitoring hydrodynamic cavitation of liquids through "labs on a chip" (i.e. microchannels with a shrinkage, such as microdiaphragms or microventuris) is an improvement in experimental approaches devoted to study the mechanisms involved in these multiphase flows. The small sizes of the reactors do not require big substructures. Flow rates of around 1 L/h make possible the characterisation of rare, toxic or expensive pure fluids or mixtures. Moreover, because of that microfluidic approach, an unique inception of the cavitation from a laminar flow regime is also possible, that provides precious databases for simulation or modelisation. Lastly, "labs on a chip" are an extremely versatile solution to perform novel experiments, as they are embeddable in tools basically designed to proceed with small samples (confocal microscopy, spectroscopy). We present here a summary of the former experiments performed by our team, concerning the fundamental aspects of hydrodynamic cavitation in a microchannel. We have recorded, with thermosensitive nanoparticles dispersed in water, the thermal signature of the growth and collapse of bubbles. We were also able to monitor the cavitation flow regime from a laminar single liquid phase. We are currently involved in applicative studies of hydrodynamic cavitation in microchannels, and preliminary results concerning liquid phase exfoliation of graphene will be also presented.Résumé -Cavitation hydrodynamique "sur puce" : Aspects fondamentaux et appliqués -L'émergence de la cavitation hydrodynamique 'sur puce' (cavitation dans des microcanaux comportant une réduction localisée de leur section de passage) est un atout pour l'étude des mécanismes impliqués dans ce type d'écoulements diphasiques. Les dimensions réduites des réacteurs s'affranchissent de l'utilisation d'infrastructures lourdes. Des débits de l'ordre du litre par heure rendent possible l'étude de fluides rares, toxiques ou coûteux, ainsi que l'étude de mélanges. De plus, cette approche microfluidique est la seule qui permet sous certaines conditions l'apparition de la cavitation à partir d'un régime d'écoulement laminaire, ce qui fournit des données expérimentales intéressantes pour la modélisation. Enfin, la dimension réduite des "laboratoires sur puce" leur permet de s'intégrer dans des schémas expérimentaux (microscopes confocaux, spectrométrie) inenvisageables à plus grande échelle. Nous présentons ici un récapitulatif de résultats récemment obtenus par notre équipe, concernant des aspects fondamentaux et appliqués au génie des procédés de la cavitation hydrodynamique sur puce. Nous avons pu détecter la signature thermique de l'évaporation et de la condensation de bulles, grâce à des nanoparticules thermofluorescentes dispersées dans l'écoulement. Nous avons également piloté la transition vers la cavitation à partir d'un écoulement laminaire. Nous présentons enfin les premiers résultats de nos travaux en cours, concernant l'exfoliation en phase liquide du graphène assistée par microcavitation.

show abstract

Sonochemistry and sonoluminescence in microfluidics

Cited by 72 publications

References 16 publications

Controlled nanoparticle release from stable magnetic microbubble oscillations

Controlled nanoparticle release from stable magnetic microbubble oscillations

Sonoluminescence and sonochemiluminescence from a microreactor

Hydrodynamic Cavitation through “Labs on a Chip”: From Fundamentals to Applications

Contact Info

Product

Resources

About