Sonochemical synthesis of a nanodandelion tin(IV) complex with carbacylamidophosphate ligand as anti-Alzheimer agent: Molecular docking study

Roumiani, Mona Eini; Dorosti, Niloufar

doi:10.1016/j.ultsonch.2019.01.025

Cited by 10 publications

(6 citation statements)

References 41 publications

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“…13b against AChE, IC 50 values of L and Ĺ are 287.70 ± 0.91 μM and 1731.41 ± 0.33 μM, and of C 1 and C 3 are 262.79 ± 0.75 μM and 1270.44 ± 0.27 μM, [14] respectively. Indeed, complexes C 1 and C 3 have an enhanced activity compared to their corresponding ligands L and Ĺ, which suggest that the reason for this activity is the presence of the metal.…”

Section: Che Activity Resultsmentioning

confidence: 91%

“…This causes the phosphorus atom in L (δ 31 P: 12.16 ppm) 13a to be more positive than in Ĺ (δ 31 P: 6.86 ppm), 13b suggesting that the electronic and steric effects cause drastically increase of the inhibitory effect of L (Table 2). It is noteworthy that the coordination of 4‐PCAPh ligands ( L and Ĺ ) to Sn (CH 3 ) 2 Cl 2 moiety from two different donor sites (N pyridine and O phosphoryl , respectively) led to increased inhibitory activity of the complexes C 1 and C 3 13b against AChE, IC 50 values of L and Ĺ are 287.70 ± 0.91 μM and 1731.41 ± 0.33 μM, and of C 1 and C 3 are 262.79 ± 0.75 μM and 1270.44 ± 0.27 μM, [ 14 ] respectively. Indeed, complexes C 1 and C 3 have an enhanced activity compared to their corresponding ligands L and Ĺ , which suggest that the reason for this activity is the presence of the metal.…”

Section: Resultsmentioning

confidence: 99%

“…[ 13 ] In our previous work, nanoparticles octahedral O ‐ligated 4‐PCAPh‐based tin (IV) complex was synthesized and the cholinesterase inhibitor activity was found. [ 14 ] Here we continue our study in this field, in particular to investigate the effect of size, and the choice of ligand and tin adducts on the ChE inhibitor activities of complexes based on pyridinecarbacylamidophosphate derivatives. 4‐PCAPh ligand, 4‐NC 5 H 4 C(O)NHP(O)(C 6 H 12 N) 2 ( L ), 13a was used to prepare two new organotin complexes SnCl 2 (CH 3 ) 2 L 2 ( C 1 ) and Sn(C 6 H 5 ) 3 ClL ( C 2 ).…”

Section: Introductionmentioning

confidence: 99%

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Nano‐ and micro‐structure tin (IV) complexes bearing 4‐pyridinecarbacylamidophosphate: Sonochemical synthesis, crystal structure, anti‐cholinesterase activity, and docking studies

Nikpour

Dorosti

Afshar

et al. 2020

Applied Organom Chemis

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Two di-and triorganotin (IV) complexes, Sn (CH 3) 2 Cl 2 (4-PCAPh) 2 (C 1) and Sn(C 6 H 5) 3 Cl(4-PCAPh) (C 2); {4-PCAPh = 4-NC 5 H 4 C(O)NHP(O) (C 6 H 12 N) 2 }, have been synthesized and characterized by elemental analysis, 1 H, 13 C, 31 P NMR and IR spectroscopy. The crystal structure of C 1 has been confirmed by X-ray crystallography, which reveals an octahedral geometry surrounding Sn (IV). Both ligands function in an all-trans conformation, with an N-ligated mode for 4-PCAPh. Also, the complexes were prepared at nano-(C 1) and micro-size (C 2) by the sonochemical process. The role of reaction solvent and the concentration of initial reactants on the size and morphology of particles were studied and the products were characterized by X-ray powder diffraction (XRPD) and scanning electron microscopy (SEM). The activities and mechanism of complexes C 1 , C 2 , C 1 , C 2 and their corresponding ligand (L) on cholinesterase (ChE) were evaluated using a modified Ellman's method and Lineweaver-Burk plots. Nanosheet C 1 showed the best activity against AChE and BChE with the IC 50 values being 73.08 ± 0.12 μM and 122.48 ± 0.69 μM, respectively, and the mixed-type mechanism. Molecular modeling simulation revealed the binding interaction template for Sn (CH 3) 2 Cl 2 (4-PCAPh) 2 with the ChE.

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Section: Che Activity Resultsmentioning

confidence: 91%

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Nano‐ and micro‐structure tin (IV) complexes bearing 4‐pyridinecarbacylamidophosphate: Sonochemical synthesis, crystal structure, anti‐cholinesterase activity, and docking studies

Nikpour

Dorosti

Afshar

et al. 2020

Applied Organom Chemis

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“…High power ultrasounds can break-down chemical bonds depolymerizing macromolecules, downsizing particles to nanoscale, making nanoemulsions, extracting bioactive substances from different matrices and so on, in research laboratories, in pharmaceutical and agrifood industries [40][41][42][43]. Sonochemistry was recently investigated for synthesis of bioactive nanostructures [44], different nanocarriers such as niosomes [45], liposomes [46], nanoemulsions [47], solid lipid nanoparticles [48], metal based systems [49], polymeric particles [50], nanoclusters [51] and nanocomposites [43]. Sonication processes were mainly performed to extract or degrade pesticides in order to support analysis and decontamination activities [52,53].…”

Section: Nanopesticides and Sonication Technologymentioning

confidence: 99%

Sonication-Assisted Production of Fosetyl-Al Nanocrystals: Investigation of Human Toxicity and In Vitro Antibacterial Efficacy against Xylella fastidiosa

Baldassarre

Tatulli²,

Vergaro

et al. 2020

Nanomaterials

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Recently, there is a growing demand in sustainable phytopathogens control research. Nanotechnology provides several tools such as new pesticides formulations, antibacterial nanomaterials and smart delivery systems. Metal nano-oxides and different biopolymers have been exploited in order to develop nanopesticides which can offer a targeted solution minimizing side effects on environment and human health. This work proposed a nanotechnological approach to obtain a new formulation of systemic fungicide fosetyl-Al employing ultrasonication assisted production of water dispersible nanocrystals. Moreover, chitosan was applicated as a coating agent aiming a synergistic antimicrobial effect between biopolymer and fungicide. Fosetyl-Al nanocrystals have been characterized by morphological and physical-chemical analysis. Nanotoxicological investigation was carried out on human keratinocytes cells through cells viability test and ultrastructural analysis. In vitro planktonic growth, biofilm production and agar dilution assays have been conducted on two Xylella fastidiosa subspecies. Fosetyl-Al nanocrystals resulted very stable over time and less toxic respect to conventional formulation. Finally, chitosan-based fosetyl-Al nanocrystals showed an interesting antibacterial activity against Xylella fastidiosa subsp. pauca and Xylella fastidiosa subsp. fastidiosa.

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“…Since the surface‐to‐volume ratio is high in these compounds, they have a lot more activities than their bulk . Therefore, a lot of studies have been carried out to synthesize these NCPs …”

Section: Introductionmentioning

confidence: 99%

Achieving Different Morphologies for a Zinc(II) Coordination Polymer by Green Sonochemical Synthesis and New Precursors for the Preparation of Zinc(II)oxide

et al. 2019

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A new 2D zinc(II) coordination polymer(CP) 1, [Zn(N 3 )(L)] n (1), [L = 2-picolinate] has been synthesized using branch tube approach. Nano and micro structures of CP 1 were synthesized using sonochemical technique in diverse conditions (different times and solvents) and they were identified by elemental analysis, FT-IR spectra, scanning electron microscopy (SEM) and powder X-ray diffraction (PXRD). Single-crystal X-ray studies show that CP1 contains Zn(II) atoms with different coordination geometries (tetrahedral and octahedral). The effects of solvents and reaction time on the morphology and size of the nano and microstructure of CP 1 were also evaluated. The results showed that change in reaction time has almost no effect on the size of particles, but change in solvent leads to changes in the morphology of particles.

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Sonochemical synthesis of a nanodandelion tin(IV) complex with carbacylamidophosphate ligand as anti-Alzheimer agent: Molecular docking study

Cited by 10 publications

References 41 publications

Nano‐ and micro‐structure tin (IV) complexes bearing 4‐pyridinecarbacylamidophosphate: Sonochemical synthesis, crystal structure, anti‐cholinesterase activity, and docking studies

Nano‐ and micro‐structure tin (IV) complexes bearing 4‐pyridinecarbacylamidophosphate: Sonochemical synthesis, crystal structure, anti‐cholinesterase activity, and docking studies

Sonication-Assisted Production of Fosetyl-Al Nanocrystals: Investigation of Human Toxicity and In Vitro Antibacterial Efficacy against Xylella fastidiosa

Achieving Different Morphologies for a Zinc(II) Coordination Polymer by Green Sonochemical Synthesis and New Precursors for the Preparation of Zinc(II)oxide

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