Sonochemical rate enhanced by a new nanomagnetic embedded core/shell nanoparticles and catalytic performance in the multicomponent synthesis of pyridoimidazoisoquinolines

Abstract

A sonochemical approach for the one-pot three-component synthesis of pyridoimidazoisoquinolines via by using phthalaldehyde, trimethylsilylcyanide and aminopyridines the presence of a catalytic amount of a new nanomagnetic catalyst FeO@SiO-CO-CH-NH is described. The characterization of the nanocatalyst and the product was done by various methods, such as FT-IR, SEM, EDX, TGA/DTA, NMR, MS and CHN analyses. This is the first design, preparation, characterization and application of the present core/shell nanomaterial and also the first ultrasound irradiated synthesis of the biologically and pharmaceutically important fused polycyclic compounds in ethanol as a green solvent. This novel protocol offers several advantages such as high yields, short reaction times, environmentally-friendly reaction media, easily isolation of the products, simple preparation and recoverability of the nanocatalyst by an external magnet and reusing several times without significant decrease in catalytic activity.

Antimicrobial therapeutic enhancement of levofloxacin via conjugation to a cell‐penetrating peptide: An efficient sonochemical catalytic process

“…Concisely, ultrasonication leads to obtain high reaction yield during a short reaction time, under a milder condition. Moreover, physical properties like well dispersion is effectively enhanced by ultrasonication 21–25 . In this study, we intend to introduce a convenient synthetic strategy for a novel medicinal conjugation including CPP hexapeptide and LVX, which passes through a comparative viewpoint between two different heterogeneous magnetic catalytic systems.…”

Facile one‐pot synthesis of a series of 7‐aryl‐8H‐benzo[h]indeno[1,2‐b]quinoline‐8‐one derivatives catalyzed by cellulose‐based magnetic nanocomposite

“…Then, an intermediate was formed from 1 ‐ naphthylamine and 1,4 ‐ dihydroquinoline during ring formation by removing an H 2 O molecule. In the final step, MCSA‐promoted the oxidation of 1,4 ‐ dihydroindenoquinolines to the target product indenoquinolines (Scheme ).…”

A decennary update on applications of metal nanoparticles (MNPs) in the synthesis of nitrogen- and oxygen-containing heterocyclic scaffolds

“…Maleki et al reported Fe 3 O 4 @SiO 2 -CO-C 6 H 4 -NH 2 as a new catalyst for the ultrasonic wave-mediated, rapid synthesis of pyridoimidazoisoquinolines (221) from o-phthalaldehyde (21g), trimethyl silane cyanide (169b) and 2-amino pyridines (150a) in ethanol in excellent yields (Scheme 118). 242 The Fe 3 O 4 @SiO 2 NPs were prepared and functionalized with 4-amino benzoyl chloride, which characterized via SEM, EDX, TGA and DTA. The heterogeneous catalyst was recycled consecutively for up to ve runs without decay in its catalytic activity.…”