Sonochemical-Assisted Biogenic Synthesis of Theophrasite β-Ni(OH)2 Nanocluster Using Chia Seeds Extract: Characterization and Anticancer Activity

Abstract

Theophrasite β-Ni(OH)2 nanocluster were fabricated via the sonochemical-assisted biogenic method using chia seeds extract as a reducing and stabilizing agent. The optical and morphological feature of the synthesized nanocluster was characterized using UV-Vis, FTIR, FE-SEM-EDS, HR-TEM, DLS, XPS, and XRD analysis. According to FE-SEM and HR-TEM images of the synthesized materials, β-Ni(OH)2 nanocluster illustrates the hexagonal particle shape with an average size of 5.8 nm, while the EDS results confirm the high purity of the synthesized nanocluster. Moreover, the XRD pattern of the synthesized materials shows typical peaks that match the reference pattern of the Theophrasite form of β-Ni(OH)2 with a hexagonal crystal system. The XPS analysis illustrates that the prepared samples exhibit both Ni2+ and Ni3+ with the predominance of Ni2+ species. Additionally the in-vitro cytotoxic activity of β-Ni(OH)2 nanocluster is tested against the MCF7 cell lines (breast cancer cells). The MTT assay results proved that the synthesized β-Ni(OH)2 nanocluster has potent cytotoxic activity against breast cancer cell lines (IC50: 62.7 μg/mL).

Cytotoxic activity of bimetallic Ag@Se green synthesized nanoparticles using Jerusalem Thorn (Parkinsonia aculeata)

“…The presence of biomolecules from the P. aculeata L. aqueous extract attached to the surface of the synthesized materials is attributed to the agglomeration and cluster formation of Ag@Se-P and Ag@Se-S nanocomposites, which confirm the role of the P. aculeata L . aqueous extract as a reducing and capping agent ( Hassanin and Taha, 2022 ; Numan et al, 2022 ). Figures 2C, D show the elemental mapping obtained from EDS analysis for the produced Ag@Se-P and Ag@Se-S nanocomposites, respectively.…”

“…Nanotechnology research provides significant advancements in the production of materials and nanoelectronics. This type of research has a wide range of applications in various fields, including biotechnology, energy, healthcare, environment, and medicine ( Yaqoob et al, 2020a ; Hassanin and Taha, 2022 ; Taha and Hassanin, 2022 ). The unique chemical and physical properties of nanomaterials were found to be size-dependent.…”

“…However, the excessive use of chemicals has some drawbacks, such as toxicity to the environment and high costs. The green synthesis of nanoparticles using plant extracts has been extensively applied recently since most plant extracts contain biologically active components that might increase the biological activity of the manufactured nanoparticles ( Hassanin et al, 2021 ; Hassanin and Taha, 2022 ; Taha and Hassanin, 2022 ).…”

Mechanochemical Synthesis of Nanoparticles for Potential Antimicrobial Applications

“…There are many methods, such as sol-gel [ 44 , 45 ], solvothermal/hydrothermal [ 46 ], Stöber [ 47 ], microemulsion [ 48 ], and methods involving microwaves [ 49 ], sonochemistry [ 50 ] and mechanochemistry, that have been used for the synthesis of NPs.…”

Nutritional and Functional New Perspectives and Potential Health Benefits of Quinoa and Chia Seeds

“…Chia-seeds-based natural gum can be used in vegan mayonnaise [153]. In addition, the extract of chia seeds is employed to synthesize biogenic nanomaterials for therapeutic applications such as anticancer activity, cytotoxicity, and photocatalytic activity [154,155]. The flavonoid and phenolic contents of chia sprouts are significantly increased up to 6.4-and 11.5-fold on germination with dry seeds, respectively [156].…”