Sono-activated ultrasound localization microscopy

Desailly, Yann; Couture, Olivier; Fink, Mathias; Tanter, Mickaël

doi:10.1063/1.4826597

Cited by 155 publications

(140 citation statements)

References 17 publications

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“…In the future, the information inferred regarding the acoustic activity within the entire skull cavity could be incorporated into existing treatment control schemes 35 in order to select optimal sonication parameters such that a desired level of cavitation activity is reached within the target volume. Apart from its use in a therapy monitoring context, since the microbubbles are confined to the vasculature until clearance by the lungs and kidneys, the method could also be combined with super-resolution techniques 61,114,115 to enable vascular mapping of the brain for diagnostic purposes. T II.…”

Section: Discussionmentioning

confidence: 99%

Experimental demonstration of passive acoustic imaging in the human skull cavity using CT‐based aberration corrections

Jones

O’Reilly

Hynynen³

2015

Medical Physics

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Purpose: Experimentally verify a previously described technique for performing passive acoustic imaging through an intact human skull using noninvasive, computed tomography (CT)-based aberration corrections Jones et al. [Phys. Med. Biol. 58, 4981-5005 (2013)]. Methods: A sparse hemispherical receiver array (30 cm diameter) consisting of 128 piezoceramic discs (2.5 mm diameter, 612 kHz center frequency) was used to passively listen through ex vivo human skullcaps (n = 4) to acoustic emissions from a narrow-band fixed source (1 mm diameter, 516 kHz center frequency) and from ultrasound-stimulated (5 cycle bursts, 1 Hz pulse repetition frequency, estimated in situ peak negative pressure 0.11-0.33 MPa, 306 kHz driving frequency) Definity™ microbubbles flowing through a thin-walled tube phantom. Initial in vivo feasibility testing of the method was performed. The performance of the method was assessed through comparisons to images generated without skull corrections, with invasive source-based corrections, and with water-path control images. Results: For source locations at least 25 mm from the inner skull surface, the modified reconstruction algorithm successfully restored a single focus within the skull cavity at a location within 1.25 mm from the true position of the narrow-band source. The results obtained from imaging single bubbles are in good agreement with numerical simulations of point source emitters and the authors' previous experimental measurements using source-based skull corrections O'Reilly et al. [IEEE Trans. Biomed. Eng. 61, 1285-1294]. In a rat model, microbubble activity was mapped through an intact human skull at pressure levels below and above the threshold for focused ultrasound-induced blood-brain barrier opening. During bursts that led to coherent bubble activity, the location of maximum intensity in images generated with CT-based skull corrections was found to deviate by less than 1 mm, on average, from the position obtained using source-based corrections. Conclusions: Taken together, these results demonstrate the feasibility of using the method to guide bubble-mediated ultrasound therapies in the brain. The technique may also have application in ultrasound-based cerebral angiography. C 2015 American Association of Physicists in Medicine.

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Section: Discussionmentioning

confidence: 99%

Experimental demonstration of passive acoustic imaging in the human skull cavity using CT‐based aberration corrections

Jones

O’Reilly

Hynynen³

2015

Medical Physics

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“…Techniques such as PALM [9] and STORM [10] which gained increasing popularity in the last decade, have revolutionized fluorescence microscopy by enabling a ten-fold improvement in spatial resolution using precise localization of photo-switchable fluorophores. Inspired by super localization techniques in fluorescence microscopy, different approaches for achieving super-localization in CEUS were proposed in [11], [12], [13]. These methods are commonly referred to as ultrasound localization microscopy (ULM).…”

Section: Introductionmentioning

confidence: 99%

Fast Vascular Ultrasound Imaging With Enhanced Spatial Resolution and Background Rejection

Bar‐Zion

Tremblay-Darveau

Solomon

et al. 2017

IEEE Trans. Med. Imaging

105

101

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Abstract-Ultrasound super-localization microscopy techniques presented in the last few years enable non-invasive imaging of vascular structures at the capillary level by tracking the flow of ultrasound contrast agents (gas microbubbles). However, these techniques are currently limited by low temporal resolution and long acquisition times. Super-resolution optical fluctuation imaging (SOFI) is a fluorescence microscopy technique enabling sub-diffraction limit imaging with high temporal resolution by calculating high order statistics of the fluctuating optical signal. The aim of this work is to achieve fast acoustic imaging with enhanced resolution by applying the tools used in SOFI to contrast-enhance ultrasound (CEUS) plane-wave scans. The proposed method was tested using numerical simulations and evaluated using two in-vivo rabbit models: scans of healthy kidneys and VX-2 tumor xenografts. Improved spatial resolution was observed with a reduction of up to 50% in the full width half max of the point spread function. In addition, substantial reduction in the background level was achieved compared to standard mean amplitude persistence images, revealing small vascular structures within tumors. The scan duration of the proposed method is less than a second while current superlocalization techniques require acquisition duration of several minutes. As a result, the proposed technique may be used to obtain scans with enhanced spatial resolution and high temporal resolution, facilitating flow-dynamics monitoring. Our method can also be applied during a breath-hold, reducing the sensitivity to motion artifacts.

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“…Recently, many super-resolution techniques based on the super-localization of spatially separated microbubble contrast agents have been described in the literature. 38,39 For example, the center of mass of isolated microbubbles can be calculated and extracted from an ultrasound image to construct super-resolved microbubble location density maps. This approach could be adapted to localize isolated ADV events.…”

Section: Discussionmentioning

confidence: 99%

Wideband acoustic activation and detection of droplet vaporization events using a capacitive micromachined ultrasonic transducer

Novell¹,

Arena²,

Oralkan³

et al. 2016

The Journal of the Acoustical Society of America

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An ongoing challenge exists in understanding and optimizing the acoustic droplet vaporization (ADV) process to enhance contrast agent effectiveness for biomedical applications. Acoustic signatures from vaporization events can be identified and differentiated from microbubble or tissue signals based on their frequency content. The present study exploited the wide bandwidth of a 128-element capacitive micromachined ultrasonic transducer (CMUT) array for activation (8 MHz) and real-time imaging (1 MHz) of ADV events from droplets circulating in a tube. Compared to a commercial piezoelectric probe, the CMUT array provides a substantial increase of the contrast-to-noise ratio.

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Sono-activated ultrasound localization microscopy

Cited by 155 publications

References 17 publications

Experimental demonstration of passive acoustic imaging in the human skull cavity using CT‐based aberration corrections

Experimental demonstration of passive acoustic imaging in the human skull cavity using CT‐based aberration corrections

Fast Vascular Ultrasound Imaging With Enhanced Spatial Resolution and Background Rejection

Wideband acoustic activation and detection of droplet vaporization events using a capacitive micromachined ultrasonic transducer

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