Sonic hedgehog, Wnt, and brain‐derived neurotrophic factor cell signaling pathway crosstalk: potential therapy for depression

Tayyab, Mohd; Shahi, Mehdi H.; Farheen, Shirin; Mariyath, Mubeena P.M.; Khanam, Nabeela; Castresana, Javier S.; Hossain, Mohammad Salim

doi:10.1002/jnr.24104

Cited by 41 publications

(26 citation statements)

References 124 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…We also detected a trend toward an overlap with genes that are differentially expressed in the Wnt/β-catenin pathway in the anterior thalamus ( Table 4 ). Wnt signaling is increasingly recognized as playing an important role in the mature central nervous system, and abnormalities in this signaling pathway have been implicated in MDD (Voleti and Duman, 2012; Zhou et al, 2016; Tayyab et al, 2018). Nuclear β-catenin accumulates in mature neurons throughout the nervous system, particularly anterior thalamic cells where it plays a role in regulating expression of voltage- and ligand-gated ion channels (Wisniewska et al, 2012).…”

Section: Discussionmentioning

confidence: 99%

Time Course of Changes in Peripheral Blood Gene Expression During Medication Treatment for Major Depressive Disorder

et al. 2019

View full text Add to dashboard Cite

Changes in gene expression (GE) during antidepressant treatment may increase understanding of the action of antidepressant medications and serve as biomarkers of efficacy. GE changes in peripheral blood are desirable because they can be assessed easily on multiple occasions during treatment. We report here on GE changes in 68 individuals who were treated for 8 weeks with either escitalopram alone, or escitalopram followed by bupropion. GE changes were assessed after 1, 2, and 8 weeks of treatment, with significant changes observed in 156, 121, and 585 peripheral blood gene transcripts, respectively. Thirty-one transcript changes were shared between the 1- and 8-week time points (seven upregulated, 24 downregulated). Differences were detected between the escitalopram- and bupropion-treated subjects, although there was no significant association between GE changes and clinical outcome. A subset of 18 genes overlapped with those previously identified as differentially expressed in subjects with MDD compared with healthy control subjects. There was statistically significant overlap between genes differentially expressed in the current and previous studies, with 10 genes overlapping in at least two previous studies. There was no enrichment for genes overexpressed in nervous system cell types, but there was a trend toward enrichment for genes in the WNT/β-catenin pathway in the anterior thalamus; three genes in this pathway showed differential expression in the present and in three previous studies. Our dataset and other similar studies will provide an important source of information about potential biomarkers of recovery and for potential dysregulation of GE in MDD.

show abstract

Section: Discussionmentioning

confidence: 99%

Time Course of Changes in Peripheral Blood Gene Expression During Medication Treatment for Major Depressive Disorder

et al. 2019

View full text Add to dashboard Cite

show abstract

“…It has been suggested that BDNF along with NT‐4 is involved in mediating the tangential migration of medial ganglionic eminence cells into the cortex of the developing telencephalon and hence plays a role in the precise organization and patterning of cortical interneurons (Polleux et al, ). It has been reported that sonic hedgehog (Shh) and BDNF proteins cooperate with each other to bring about the modulation of different biological mechanisms (Bond, Angeloni, Harrington, Stupp, & Podlasek, ; Radzikinas et al, ; Tayyab et al, ). BDNF, for example, is known to cause the upregulation of Shh expression at both the mRNA and protein level.…”

Section: Bdnf and Brain Developmentmentioning

confidence: 99%

Neuroanatomical distribution and functions of brain‐derived neurotrophic factor in zebrafish (Danio rerio) brain

Anand

Mondal

2019

J of Neuroscience Research

View full text Add to dashboard Cite

Brain‐derived neurotrophic factor (BDNF) is an extensively studied protein that is evolutionarily conserved and widely distributed in the brain of vertebrates. It acts via its cognate receptors TrkB and p75NTR and plays a central role in the developmental neurogenesis, neuronal survival, proliferation, differentiation, synaptic plasticity, learning and memory, adult hippocampal neurogenesis, and brain regeneration. BDNF has also been implicated in a plethora of neurological disorders. Hence, understanding the processes that are controlled by BDNF and their regulating mechanisms is important. Although, BDNF has been thoroughly studied in the mammalian models, contradictory effects of its functions have been reported on several occasions. These contradictory effects may be attributed to the sheer complexity of the mammalian brain. The study of BDNF and its associated functions in a simpler vertebrate model may provide some clarity about the effects of BDNF on the neurophysiology of the brain. Keeping that in mind, this review aims at summarizing the current knowledge about the distribution of BDNF and its associated functions in the zebrafish brain. The main focus of the review is to give a comparative overview of BDNF distribution and function in zebrafish and mammals with respect to distinct life stages. We have also reviewed the regulation of bdnf gene in zebrafish and discussed its role in developmental and adult neurogenesis.

show abstract

“…it is overexpressed in a variety of human malignancies, including gastric (38), ovarian (39) and breast (40) cancers. aberrant expression of BdnF is closely associated with oncogenesis and development of human cancers through regulation of various biological behaviors (41)(42)(43). a previous study also reported the upregulation of BdnF in Hcc and that BdnF upregulation may serve key roles in the genesis and progression of Hcc (23).…”

Section: Bdnf Is a Direct Target Of Mir-584 In Hccmentioning

confidence: 99%

MicroRNA‑584 prohibits hepatocellular carcinoma cell proliferation and invasion by directly targeting BDNF

et al. 2019

View full text Add to dashboard Cite

in recent decades, an increasing number of studies have demonstrated that numerous micrornas (mirnas) are dysregulated in hepatocellular carcinoma (Hcc); these aberrantly expressed mirnas are contributing regulators of Hcc formation and progression. Thus, revealing the biological roles of mirnas in Hcc may provide novel information on the identification of effective therapeutic targets and valuable diagnosis methods. Herein, reverse transcription-quantitative Pcr was performed to determine the expression profile of miRNA-584 (miR-584) in HCC tissues and cell lines. Cell Counting Kit-8 and cell invasion assays were utilized to evaluate the influence of mIR-584 overexpression on HCC cell proliferation and invasion, respectively. The present study demonstrated that miR-584 expression was reduced in Hcc tissues and cell lines compared with normal controls. clinical analysis indicated that decreased miR-584 expression was significantly associated with tumor size, TnM stage and lymph node metastasis of patients with HCC. Additionally, resumption of miR-584 expression inhibited proliferation and invasion of Hcc cells. Mechanistically, it was demonstrated that miR-584 can directly interact with the 3'-untranslated regions of brain-derived neurotrophic factor (BdnF) mrna, and reduce its mrna and protein levels in Hcc cells. Furthermore, BdnF was upregulated in Hcc tissues, and its level was inversely correlated with miR-584 expression. notably, restored BdnF expression antagonized the inhibitory effects of miR-584 overexpression on HCC cells. In conclusion, miR-584 may serve tumor-suppressive roles in HCC by directly targeting BDNF, thus suggesting that miR-584 may serve as a potential candidate for treatment of patients with this disease.

show abstract

Sonic hedgehog, Wnt, and brain‐derived neurotrophic factor cell signaling pathway crosstalk: potential therapy for depression

Cited by 41 publications

References 124 publications

Time Course of Changes in Peripheral Blood Gene Expression During Medication Treatment for Major Depressive Disorder

Time Course of Changes in Peripheral Blood Gene Expression During Medication Treatment for Major Depressive Disorder

Neuroanatomical distribution and functions of brain‐derived neurotrophic factor in zebrafish (Danio rerio) brain

MicroRNA‑584 prohibits hepatocellular carcinoma cell proliferation and invasion by directly targeting BDNF

Contact Info

Product

Resources

About