Sonic Hedgehog Acts as a Negative Regulator of β-Catenin Signaling in the Adult Tongue Epithelium

Schneider, Fabian T.; Schänzer, Anne; Czupalla, Cathrin J.; Thom, Sonja; Engels, Knut; Schmidt, Mirko H. H.; Plate, Karl H.; Liebner, Stefan

doi:10.2353/ajpath.2010.091079

Cited by 36 publications

(33 citation statements)

References 44 publications

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“…54,59 In addition, sub-cellular localization of markers has been shown to be a better indicator of EMT. 10,14,59,78 A potential possibility is that sub-cellular localization may be an indicator of early EMT whereas total levels may be an indicator of late EMT. Additional work to clarify these potential issues will better delineate the mechanisms that regulate the dynamic EMT program in HNSCC.…”

Section: Resultsmentioning

confidence: 99%

Epithelial to mesenchymal transition in head and neck squamous cell carcinoma

Smith¹,

Teknos²,

Pan³

2013

Oral Oncology

196

181

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Section: Resultsmentioning

confidence: 99%

Epithelial to mesenchymal transition in head and neck squamous cell carcinoma

Smith¹,

Teknos²,

Pan³

2013

Oral Oncology

196

181

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“…185 Specifically, HH signalling was found to inhibit Wnt signalling via upregulation of sFRP-1, 185 and to suppress β-catenin transcriptional activity. 186 Furthermore, HH signalling can induce the Notch ligand Jagged2, at least in some models. 187 These findings suggests that HH-pathway inhibitors might, at least in some cases, inhibit Jagged2-mediated Notch signalling, but may also trigger a compensatory increase in Wnt signalling.…”

Section: Crosstalk Between Signalling Pathwaysmentioning

confidence: 99%

Targeting Notch, Hedgehog, and Wnt pathways in cancer stem cells: clinical update

et al. 2015

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During the past decade, cancer stem cells (CSCs) have been increasingly identified in many malignancies. Although the origin and plasticity of these cells remain controversial, tumour heterogeneity and the presence of small populations of cells with stem-like characteristics is established in most malignancies. CSCs display many features of embryonic or tissue stem cells, and typically demonstrate persistent activation of one or more highly conserved signal transduction pathways involved in development and tissue homeostasis, including the Notch, Hedgehog (HH), and Wnt pathways. CSCs generally have slow growth rates and are resistant to chemotherapy and/or radiotherapy. Thus, new treatment strategies targeting these pathways to control stem-cell replication, survival and differentiation are under development. Herein, we provide an update on the latest advances in the clinical development of such approaches, and discuss strategies for overcoming CSC-associated primary or acquired resistance to cancer treatment. Given the crosstalk between the different embryonic developmental signalling pathways, as well as other pathways, designing clinical trials that target CSCs with rational combinations of agents to inhibit possible compensatory escape mechanisms could be of particular importance. We also share our views on the future directions for targeting CSCs to advance the clinical development of these classes of agents.

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“…This crosstalk appears to be mutual and even complex with the involvement of common components but different functional aspects of the GLI transcription factors and tissue specificity. In adult tongue epithelium dominant activation of β-catenin lead to a significant up-regulation of Shh which then diminished β-catenin signaling [180]. Vice versa, IHh is a target of Wnt/β-catenin, and in liver it has been shown that the perivenous area expressing IHh is extended upon activation of β-catenin signaling [164].…”

Section: Hypoxia Hifs and Hedgehog Signaling: Another Liaisonmentioning

confidence: 99%

Metabolic zonation of the liver: The oxygen gradient revisited

2017

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The liver has a multitude of functions which are necessary to maintain whole body homeostasis. This requires that various metabolic pathways can run in parallel in the most efficient manner and that futile cycles are kept to a minimum. To a large extent this is achieved due to a functional specialization of the liver parenchyma known as metabolic zonation which is often lost in liver diseases. Although this phenomenon is known for about 40 years, the underlying regulatory pathways are not yet fully elucidated. The physiologically occurring oxygen gradient was considered to be crucial for the appearance of zonation; however, a number of reports during the last decade indicating that β-catenin signaling, and the hedgehog (Hh) pathway contribute to metabolic zonation may have shifted this view. In the current review we connect these new observations with the concept that the oxygen gradient within the liver acinus is a regulator of zonation. This is underlined by a number of facts showing that the β-catenin and the Hh pathway can be modulated by the hypoxia signaling system and the hypoxia-inducible transcription factors (HIFs). Altogether, we provide a view by which the dynamic interplay between all these pathways can drive liver zonation and thus contribute to its physiological function.

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Sonic Hedgehog Acts as a Negative Regulator of β-Catenin Signaling in the Adult Tongue Epithelium

Cited by 36 publications

References 44 publications

Epithelial to mesenchymal transition in head and neck squamous cell carcinoma

Epithelial to mesenchymal transition in head and neck squamous cell carcinoma

Targeting Notch, Hedgehog, and Wnt pathways in cancer stem cells: clinical update

Metabolic zonation of the liver: The oxygen gradient revisited

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