Sonhafouonic acid, a new cytotoxic and antifungal hopene-triterpenoid from Zehneria scabra camerunensis

Kongue, Michel D. T.; Talontsi, Ferdinand Mouafo; Lamshöft, Marc; Kenla, Timothee J.N.; Dittrich, Birger; Kapche, Gilbert Deccaux Wabo Fotso; Spiteller, Michael

doi:10.1016/j.fitote.2013.01.009

Cited by 12 publications

(9 citation statements)

References 13 publications

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“…Researchers from previous studies have reported cytotoxic effects from the isolates of Acacia spp . [33], Albizia species [34] and Zehneria scabra [35]. …”

Section: Resultsmentioning

confidence: 99%

“…Had we seen a patient with the condition before treatment, then perhaps we would have made a diagnosis. However, the fact that some of the plants used in the treatment of the condition such as Acacia spp ., Albizia species and Zehneria scabra have been shown to possess some cytotoxic activities may actually suggest that it is actually cancer [33-35]. Indeed cancer was the condition treated by the highest number of species, indicating the complexity of the condition (Table 5).…”

Section: Resultsmentioning

confidence: 99%

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A study of the medicinal plants used by the Marakwet Community in Kenya

Kipkore

Wanjohi

Rono

et al. 2014

J Ethnobiology Ethnomedicine

133

104

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BackgroundThe medicinal plants used by herbalists in Kenya have not been well documented, despite their widespread use. The threat of complete disappearance of the knowledge on herbal medicine from factors such as deforestation, lack of proper regulation, overexploitation and sociocultural issues warrants an urgent need to document the information. The purpose of the study was to document information on medicinal plants used by herbalists in Marakwet District towards the utilization of indigenous ethnobotanical knowledge for the advancement of biomedical research and development.MethodsSemi- structured oral interviews were conducted with 112 practicing herbalists. The types of plants used were identified and the conditions treated recorded.ResultsHerbal practice is still common in the district, and 111 plants were identified to have medicinal or related uses. Different herbal preparations including fruits and healing vegetables are employed in the treatment of various medical conditions. Veterinary uses and pesticides were also recorded.ConclusionThe study provides comprehensive ethnobotanical information about herbal medicine and healing methods among the Marakwet community. The identification of the active ingredients of the plants used by the herbalists may provide some useful leads for the development of new drugs.

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“…Researchers from previous studies have reported cytotoxic effects from the isolates of Acacia spp . [33], Albizia species [34] and Zehneria scabra [35]. …”

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

A study of the medicinal plants used by the Marakwet Community in Kenya

Kipkore

Wanjohi

Rono

et al. 2014

J Ethnobiology Ethnomedicine

133

104

View full text Add to dashboard Cite

show abstract

“…Several terpenoids have been isolated from Ethiopian plants that have claims of having anticancer activity, although these plants may have been collected from other sources. For example, sonhafouonic acid ( 8 ) from Zehneria scabra , collected from Cameroon, demonstrated potent cytotoxicity against brine shrimp assay [ 66 ], while Lin et al [ 67 ] showed the antiproliferative activity of euphol ( 9 ), isolated from Euphorbia tirucalli from Taiwan against human gastric cancer cells. Euphol selectively promotes apoptosis by mitochondrial-dependent caspase-3 activation and growth arrest through induction of p27kip1 and inhibition of cyclin B1 in human gastric CS12 cancer cells.…”

Section: Phytochemistry Of Ethiopian Anticancer Plantsmentioning

confidence: 99%

Ethiopian Medicinal Plants Traditionally Used for the Treatment of Cancer, Part 2: A Review on Cytotoxic, Antiproliferative, and Antitumor Phytochemicals, and Future Perspective

et al. 2020

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This review provides an overview on the active phytochemical constituents of medicinal plants that are traditionally used to manage cancer in Ethiopia. A total of 119 articles published between 1968 and 2020 have been reviewed, using scientific search engines such as ScienceDirect, PubMed, and Google Scholar. Twenty-seven medicinal plant species that belong to eighteen families are documented along with their botanical sources, potential active constituents, and in vitro and in vivo activities against various cancer cells. The review is compiled and discusses the potential anticancer, antiproliferative, and cytotoxic agents based on the types of secondary metabolites, such as terpenoids, phenolic compounds, alkaloids, steroids, and lignans. Among the anticancer secondary metabolites reported in this review, only few have been isolated from plants that are originated and collected in Ethiopia, and the majority of compounds are reported from plants belonging to different areas of the world. Thus, based on the available bioactivity reports, extensive and more elaborate ethnopharmacology-based bioassay-guided studies have to be conducted on selected traditionally claimed Ethiopian anticancer plants, which inherited from a unique and diverse landscape, with the aim of opening a way forward to conduct anticancer drug discovery program.

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“…Curtisia dentata revealed the presence of triterpenoinds such as β-amyrin (53.30%), α-amyrin (6.42%), β-sitosterol (2.47%) and vitamin E (4.99%), while Markhamia obtusifolia yielded the presence of neophytadiene (4.38%), palmitic acid (3.61%) and 4-(1E)-3-Hydroxy-1-propenyl)-2-methoxyphenol (2.04%). Triterpenes are well known to possess potential antifungal activity against both human and crop infecting fungal strains (Liu et al., 2015; Kongue et al., 2013; Hu et al., 2018).…”

Section: Resultsmentioning

confidence: 99%

Antifungal and anti-mycotoxigenic activity of selected South African medicinal plants species

Dikhoba

Mongalo

Elgorashi

et al. 2019

Heliyon

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A B S T R A C TAntifungal and anti-mycotoxigenic activity of 25 acetone leaf extracts of South African medicinal plants with potent antioxidant activity were investigated against three phytopathogenic fungal strains. The extracts exhibited varying degrees of in vitro anti-mycotoxigenic effect against Fusarium verticillioides, Aspergillus flavus and Aspergillus ochraceous. Markhamia obtusifolia (Baker) Sprague exhibited the lowest minimum inhibitory concentration (MIC) values as low as 0.08 mg/ml against Aspergillus flavus and Furasium verticilloides at both 24 and 48 hr incubation period, while Curtisia dentata exhibited similar MIC value against Aspergillus ochraceous. Curtisia dentata further yielded the highest total activity of 1583 ml/g against Aspergillus ochraceous at 24 and 48 hr incubation period. In the mycelial growth inhibition (MGI) evaluation, Fusarium verticilloides was more sensitive to plants extracts, while Kirkia wilmsii exhibited highest MGI of 50.08% against Fusarium verticilloides on the 6 th day of incubation. Five acetone extracts from Acokanthora oppositifolia, Bauhinia galpinii, Combretum caffrum, Ricinus communis and Solanum aculeastrum exhibited lowest IC 50 value of 0.01 mg/ml against (2,2'-azinobis-3-ethylbenzthiazoline-6suphonic acid (ABTS). Curtisia dentata and Markhamia obtusifolia extracts were further subjected to gas chromatography mass-spectrophotometry (GC-MS) analysis. Curtisia dentata revealed the presence of triterpenoid compounds, β-amyrin (53.30%) and α-amyrin (6.42%), while Markhamia obtusifolia yielded the presence of neophytadiene (4.38%) and palmitic acid (3.61%) The results suggest that natural products from plants may well be used as possible substitutes for synthetic fungicides. Given the antifungal and antioxidant potential of the selected plants, they may have potential as possible leads for the development of biofungicides that may well prevent oxidation related food spoilage.

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Sonhafouonic acid, a new cytotoxic and antifungal hopene-triterpenoid from Zehneria scabra camerunensis

Cited by 12 publications

References 13 publications

A study of the medicinal plants used by the Marakwet Community in Kenya

A study of the medicinal plants used by the Marakwet Community in Kenya

Ethiopian Medicinal Plants Traditionally Used for the Treatment of Cancer, Part 2: A Review on Cytotoxic, Antiproliferative, and Antitumor Phytochemicals, and Future Perspective

Antifungal and anti-mycotoxigenic activity of selected South African medicinal plants species

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