Something to talk about: Enhancement of linguistic cohesion through tdCS in chronic non fluent aphasia

Marangolo, Paola; Fiori, Valentina; Campana, Serena; Calpagnano, Maria A.; Razzano, Carmelina; Caltagirone, Carlo; Marini, Andrea

doi:10.1016/j.neuropsychologia.2013.12.003

Cited by 57 publications

(61 citation statements)

References 44 publications

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“…Interestingly, all of these impairments appeared to be related. These findings will be discussed here in the light of one the most influential models of message production (Indefrey & Levelt, 2004;Levelt, 1989) and some recent experimental findings focusing on the neural correlates of macrolinguistic processing in aphasia (e.g., Marangolo et al, 2014).…”

Section: Discussionmentioning

confidence: 87%

The effect of lexical deficits on narrative disturbances in fluent aphasia

Andreetta

Marini

2014

Aphasiology

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Aims: This study aims at investigating micro- and macrolinguistic skills in persons with fluent aphasia. The label “fluent aphasia” applies to different aphasic syndromes characterized by fluent speech with difficulties in lexical retrieval and/or grammatical processing. We hypothesized that their lexical and syntactic (i.e., microlinguistic) difficulties would affect also their narrative (i.e., macrolinguistic) skills. \ud Methods & Procedures: Growing evidence shows that traditional tests may not be sensitive enough to capture the patterns of the linguistic impairments observed in these persons. Therefore, we used a narrative task to elicit linguistic samples. Spontaneous speech was elicited through a picture description task. The narrative samples were analyzed with a multi-level approach that allows clinicians to quantify their productivity levels as well as their lexical, grammatical, and narrative skills. The spontaneous speech produced by a group of 20 persons with fluent aphasia was compared to that of a group of 20 healthy participants. All participants with aphasia were in the phase of neurological stability. The two groups were matched for age and level of formal education.\ud Outcomes & Results: Results showed that the lexical impairment observed in the group of participants with fluent aphasia were related to difficulties also in the grammatical construction of the utterances and in the macrolinguistic organization of their speech samples. \ud Conclusions: These findings support the possibility that in these patients microlinguistic difficulties might affect macrolinguistic processing. Furthermore, these results stress the importance of a multi-level approach to assess linguistic skills in patients with fluent aphasia, as it assesses both micro- and macrolinguistic dimensions in parallel. Therefore, it allows linguists, psychologists and clinicians to observe how the linguistic levels interact during natural language processing

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Section: Discussionmentioning

confidence: 87%

The effect of lexical deficits on narrative disturbances in fluent aphasia

Andreetta

Marini

2014

Aphasiology

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“…Several studies have already applied tDCS to Broca’s area in patients following stroke and found beneficial effects in language recovery (Fiori et al, 2013; Marangolo & Caltagirone, 2014; Marangolo et al, 2014; Monti et al, 2008), however one study found no benefit (Polanowska, Lesniak, Seniow, & Czlonkowska, 2013). These studies, taken with the current findings, support the use of anodal tDCS to both the left PFC and PPC to enhance LTM skills.…”

Section: Discussionmentioning

confidence: 99%

Enhanced long-term memory encoding after parietal neurostimulation

2014

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Neurostimulation, e.g. transcranial direct current stimulation (tDCS), shows promise as an effective cognitive intervention. In spite of low spatial resolution, limited penetration, and temporary influence, evidence highlights tDCS-linked cognitive benefits in a range of cognitive domains. The left posterior parietal cortex (PPC) is an accessible node in frontoparietal networks engaged during long-term memory (LTM). Here, we tested the hypothesis that tDCS can facilitate LTM by pairing LTM encoding and retrieval with PPC stimulation. Healthy young adults performed a verbal LTM task (California Verbal Learning Task: CVLT) with four different stimulation parameters. In Experiment 1, we applied tDCS to left PPC during LTM encoding. In Experiment 2, we applied tDCS just prior to retrieval to test the temporal specificity of tDCS during a LTM task. In later Experiments, we tested hemispheric specificity by replicating Experiment 1 while stimulating the right PPC. Experiment 1 showed that tDCS applied during LTM encoding improved the pace of list learning and enhanced retrieval after a short delay. Experiment 2 indicated anodal left PPC tDCS only improved LTM when applied during encoding, and not during maintenance. Experiments 3 and 4 confirmed that tDCS effects were hemisphere specific and that no effects were found after right PPC stimulation during encoding. These findings indicate that anodal tDCS to the PPC helps verbal LTM in healthy young adults under certain conditions. First, when it is applied to the left, not the right, PPC and second, when it is applied during encoding.

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“…Thus, the design and interpretation of most of the research addressed only the current delivered over the targeted region. This led to two neuromodulation strategies: either increasing excitability through anodal stimulation over the left hemisphere [5][6][7][8][9]11,[13][14][15][16]20,21] or by decreasing excitability in the contralesional language homologue areas using cathodal stimulation in order to attenuate the inhibition from the intact right hemisphere [10,12,15,[17][18][19][20]. Indeed, while in the context of acute or subacute lesions of the left hemisphere language network there appears to be greater tendency for reallocation of language function into the right-hemisphere perisylvian circuits, many studies have shown that, over time, there is, for a number of patients at least, diminished recruitment of right hemisphere structures for language tasks with a redistribution of language processing back to the left hemispheric perisylvian areas [22][23][24].…”

Section: A C C E P T E D Accepted Manuscriptmentioning

confidence: 99%

“…In the past decade, researchers have investigated the use of noninvasive neuromodulation techniques and, in particular, transcranial direct current stimulation (tDCS) to promote language recovery in poststroke aphasia [3]. While the first published study [4] that documented tDCS use for aphasia rehabilitation did not include a behavioral treatment protocol, studies since then have combined tDCS with speech-language therapy [5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20][21]. These initial studies generally included behavioral treatment for anomia and implemented noun retrieval as the outcome measure; more recent studies have included additional behavioral treatments for the recovery of verbs [5,7,13], articulation [9] and discourse productivity [6,8].…”

Section: Introductionmentioning

confidence: 99%