Some treatment dilemmas in rapidly developing dementia: A case report

Jakovljević, Miro; Vuksan-Cusa, Bianka; Topić, Radmila

doi:10.1080/15622970701568370

The World Journal of Biological Psychiatry

2008

DOI: 10.1080/15622970701568370

|View full text |Cite

Some treatment dilemmas in rapidly developing dementia: A case report

Miro Jakovljević

Bianka Vuksan-Cusa²,

Radmila Topić³

Abstract: The treatment of rapidly deteriorating dementia is always very challenging. This case report describes a 78-year-old male patient with rapidly developing dementia treated successfully with orally disintegrating olanzapine, memantine, donepezil, omega-3 and vitamin-B complex. The prevailing fatalism and treatment nihilism regarding treatment of dementia should give way to more hope and optimism. Several important treatment dillemas in rapidly developing dementia are discussed.

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...

Citation Types

Supporting

Mentioning

Contrasting

Year Published

2008

Publication Types

Select...

Article1

Relationship

Self Cite0

Independent1

Authors

Journals

Cited by 1 publication

References 22 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

Current awareness in geriatric psychiatry

2008

Int J Geriat Psychiatry

View full text Add to dashboard Cite

Formulation of therapeutic proteins into particulate forms is a main strategy for site‐specific and prolonged protein delivery as well as for protection against degradation. Precise control over protein particle size, dispersity, purity, as well as mild preparation conditions and minimal processing steps are highly desirable. It is, however, hard to fit all these criteria with conventional preparation techniques. Here a one‐step hard‐templating synthesis of microparticles composed of functional, non‐denatured protein is reported. The method is based on filling porous CaCO3 microtemplates with the protein near to its isoelectric point (pI) followed by pH‐ or EDTA‐mediated dissolution of the tempplates. In principle, a wide variety of proteins can be converted into microparticles using this approach. The main requirement is an overlap of the protein insolubility and a template solubility for a certain parameter (here pH or EDTA). Here the formulation of insulin particles is studied in detail and it is shown that particles consisting of high molecular weight protein (catalase) can also be prepared. In this context, the synthesis of CaCO3 templates with controlled size, the mechanism of the protein microparticle formation and mechanical properties of the microparticles are discussed. For the first time, the fabrication of mesoporous monodispersed CaCO3 microtemplates with identical porocity but tuned diameter from 3 to 20 μm is demonstrated. The protein particle diameter can be adjusted by choosing the appropriate template size that is critical for successful pulmonary delivery of insulin. As a first step towards insulin delivery, the in vitro release of insulin at physiological conditions is studied.

show abstract

Current awareness in geriatric psychiatry

2008

Int J Geriat Psychiatry

View full text Add to dashboard Cite

show abstract

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

Contact Info

hi@scite.ai

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA

Blog Terms and Conditions API Terms Privacy Policy Contact Cookie Preferences Do Not Sell or Share My Personal Information

Made with 💙 for researchers

Part of the Research Solutions Family.

Some treatment dilemmas in rapidly developing dementia: A case report

Cited by 1 publication

References 22 publications

Current awareness in geriatric psychiatry

Current awareness in geriatric psychiatry

Contact Info

Product

Resources

About