Some thoughts on the nature of ectopic parathyroid hormones

Roof, Betty S.; Carpenter, Brian; Fink, Diane J.; Gordan, Gilbert S.

doi:10.1016/0002-9343(71)90124-0

Cited by 112 publications

(17 citation statements)

References 13 publications

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“…However, in a study of 26 patients with cancer (20 were normocalcemic; 6 were hypercalcemic and 2 of these had a clear-cut ectopic hyperparathyroidism syndrome) Roof, Carpenter, Fink, and Gordan (14) found that the more sensitive of their two antisera failed to recognize IPTH in the sera of 11 of these 26 patients, but IPTH could be detected in these patients using the other antiserum.…”

Section: Discussionmentioning

confidence: 96%

Immunologic differentiation of primary hyperparathyroidism from hyperparathyroidism due to nonparathyroid cancer

Riggs¹,

Arnaud²,

Reynolds³

et al. 1971

J. Clin. Invest.

158

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A B S T R A C T Serum immunoreactive parathyroid hormone (IPTH) was measured by radioimmunoassay in 54 patients with primary hyperparathyroidism and in 18 consecutive patients with ectopic hyperparathyroidism due to nonparathyroid cancer without apparent skeletal metastasis. Although serum calcium concentration was higher in the group with ectopic hyperparathyroidism, serum IPTH was lower (rank sum test, P < 0.001) and was undetectable in eight. A second anti-PTH antiserum also differentiated between IPTH in the two groups, although IPTH was undetectable in only 1 of 14 sera. When IPTH values in serial dilutions were plotted, slopes for the two patients with ectopic hyperparathyroidism who had relatively high IPTH were less (P < 0.001) than slopes for standard hyperparathyroid sera. By using differences in either IPTH rank or slope of the dilutional curve of sera, primary hyperparathyroidism could be excluded as a cause of the hypercalcemia in 16 of the 18 patients with ectopic hyperparathyroidism. The data are interpreted as indicating that PTH-like material in the serum of these patients with ectopic hyperparathyroidism is immunologically different from the PTH in the serum of patients with primary hyperparathyroidism.

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Section: Discussionmentioning

confidence: 96%

Immunologic differentiation of primary hyperparathyroidism from hyperparathyroidism due to nonparathyroid cancer

Riggs¹,

Arnaud²,

Reynolds³

et al. 1971

J. Clin. Invest.

158

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“…Whether this fragment is also active in other tissues remains to be explored. The presence of long-persisting, biologically, and immunologically active PTH fragment in the circulation explains why, according to reports from several laboratories, plasma or serum PTH may be normal in some patients with primary hyperparathyroidism (13,14). Antisera having high affinity for glandular hormone but low affinity for peak III would be expected to yield assay results in the normal range in hyperparathyroidism even though the actual concentration of biologically active hormone is high.…”

Section: Discussionmentioning

confidence: 99%

Activation of Renal Cortical Adenylate Cyclase by Circulating Immunoreactive Parathyroid Hormone Fragments

Canterbury¹,

Levey²,

Reiss³

1973

J. Clin. Invest.

122

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Section: Hypercalcaemia I N Cancermentioning

confidence: 99%

“…With some new antibodies, evidence was presented from two groups that circulating immunoreactive PTH in hypercalcaemic cancer patients differed from authentic PTH (Roof et al, 1971;Benson et al, 1974), and furthermore the levels in plasma were lower than in primary hyperparathyroidism. In one study, the cancer immunoreactivity was significantly non-parallel to PTH standards (Roof et al, 1971), and in the other it was of higher molecular weight than PTH (Benson et al, 1974). A crucial study carried out at that time, however, was that of Powell et al (1973) who found in several patients with humoral hypercalcaemia whose tumour extracts resorbed bone in vitro, that PTH could not be detected either in plasma or in tumour extracts, despite the use of a wide range of PTH antisera directed against several different parts of the molecule.…”

Section: Hypercalcaemia I N Cancermentioning

confidence: 99%