Some solvents for antiepileptics have proepileptic potencies in the WAG/Rij rat model for absence epilepsy

Peeters, B.W.M.M.; Cheung, Ka-chun; Vossen, J.M.H.; Coenen, A.M.L.

doi:10.1016/0361-9230(92)90092-c

Cited by 10 publications

(5 citation statements)

References 8 publications

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“…CNS side effects in low-birthweight infants have been associated with PPG ingestion [19][20][21] and may be related to PPG accumulation following multiple oral dosing regimes [22]. Rats that were injected with a PPG mixture had an increase in epilepticwave discharges [23]. Other components of the Ativan preparation also have significant side effects.…”

Section: Discussionmentioning

confidence: 99%

Myoclonus Associated with Lorazepam Therapy in Very-Low-Birth-Weight Infants

1994

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Lorazepam is being used with increasing frequency as a sedative in the newborn and the young infant. Concern has been raised with regard to the safety of lorazepam in this age group, especially in very-low-birth-weight (VLBW; < 1,500 g) infants. Three young infants, all of birth weight < 1,500 g, experienced myoclonus following the intravenous administration of lorazepam. The potential neurotoxic effects of the drug (and its vehicle) in this population are discussed. Injectable lorazepam should be used with caution in VLBW infants.

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Section: Discussionmentioning

confidence: 99%

Myoclonus Associated with Lorazepam Therapy in Very-Low-Birth-Weight Infants

1994

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“…There is now ample literature [27][28][29][30][31][32][33][34][35][36][37][38][39] to support the conclusion that many of the surfactants, administered parenterally to humans in vaccines, such as aluminum, mercury, and polysorbate 80 (in the acidic pH range), raise blood surface tension, leading to an increase in surface tension of intracellular, extracellular, and interstitial water, resulting in a pathology that we will refer to henceforth as "water stress". Throughout this paper, we will refer to water stress as a property of interfacial water-interfacial tension-which destabilizes enzymes, protein structure, and cell membranes [20,21,[40][41][42][43][44][45][46][47][48][49].…”

Section: Introductionmentioning

confidence: 99%

The Initial Common Pathway of Inflammation, Disease, and Sudden Death

Davidson¹,

Seneff²

2012

Entropy

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Abstract:In reviewing the literature pertaining to interfacial water, colloidal stability, and cell membrane function, we are led to propose that a cascade of events that begins with acute exogenous surfactant-induced interfacial water stress can explain the etiology of sudden death syndrome (SDS), as well as many other diseases associated with modern times. A systemic lowering of serum zeta potential mediated by exogenous cationic surfactant administration is the common underlying pathophysiology. The cascade leads to subsequent inflammation, serum sickness, thrombohemorrhagic phenomena, colloidal instability, and ultimately even death. We propose that a sufficient precondition for sudden death is lowered bioavailability of certain endogenous sterol sulfates, sulfated glycolipids, and sulfated glycosaminoglycans, which are essential in maintaining biological equipose, energy metabolism, membrane function, and thermodynamic stability in living organisms. Our literature review provides the basis for the presentation of a novel hypothesis as to the origin of endogenous bio-sulfates which involves energy transduction from sunlight. Our hypothesis is amply supported by a growing body of data showing that parenteral administration of substances that lower serum zeta potential results in kosmotropic cationic and/or chaotropic anionic interfacial water stress, and the resulting cascade.Keywords: inflammation; serum sickness; colloidal instability; interfacial water stress; bio-sulfates; Shwartzman phenomena; sudden death syndrome Glossary of TermsAnaphylaxis a severe, rapidly progressing, life-threatening, generalized allergic reaction. Biological equipoise a stable, non-equilibrium, dissipative system synonymous with life. Cholesterol sulfate (Ch-S)quantitatively the most important known sterol sulfate in human plasma where it regulates the activity of the serine proteases, in cell membranes where it has a stabilizing role, and in platelet membranes where it supports platelet adhesion. Coherence domain (CD)a water CD is a collection of liquid water molecules which oscillate in unison in tune with a self-trapped electromagnetic field at a well-defined frequency. The coherent oscillations produce an ensemble of quasi-free electrons, able to collect noise energy from the environment and transform it into high-grade coherent energy in the form of electron vortices. This high-grade energy may then activate biomolecules resonating with the water CD. Colloidal instabilitya property attributed to a colloidal suspension that develops when stabilizing repulsive steric and electrostatic forces between colliding particles are insufficient to prevent their natural tendency to aggregate into masses large enough to precipitate.Colloidal suspension a colloid that has a continuous liquid phase in which a solid is suspended in a liquid, e.g., our flowing blood. Exclusion zone (EZ)a glass-like, gel phase consisting of water CDs resonating in-phase, adjacent to hydrophilic surfaces, several hundred micrometers wide which excludes colloi...

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“…A second reason for having a solvent control group is that some solvents, e.g. Tween 80 and a mixture of saline/ethanol/propylene glycol, even when administered systemically, increase the incidence of SWDs (Peeters et al, 1992a). But also i.c.…”

Section: Male Versus Female Ratsmentioning

confidence: 99%

Establishing Drug Effects on Electrocorticographic Activity in a Genetic Absence Epilepsy Model: Advances and Pitfalls

Luijtelaar

Oijen

2020

Front. Pharmacol.

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The genetic rat models such as rats of the WAG/Rij strain and GAERS were developed as models for generalized genetic epilepsy and in particular for childhood absence epilepsy. These animal models were described in the eighties of the previous century and both models have, among others, face, construct and predictive validity. Both models were and are currently used as models to predict the action of antiepileptic medication and other experimental treatments, to elucidate neurobiological mechanisms of spike-wave discharges and epileptogenesis. Although the electroencephalagram (EEG)/ electrocorticogram (ECoG) is imperative for establishing absence seizures and to quantify the for absence epilepsy typical spike-wave discharges, monitoring the animals behavior is equally necessary. Here an overview is given regarding the design of drug evaluation studies, which animals to use, classical and new EEG variables, the monitoring and quantification of the behavior of the rats, some pitfalls regarding the interpretation of the data, and some developments in EEG technology.

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Some solvents for antiepileptics have proepileptic potencies in the WAG/Rij rat model for absence epilepsy

Cited by 10 publications

References 8 publications

Myoclonus Associated with Lorazepam Therapy in Very-Low-Birth-Weight Infants

Myoclonus Associated with Lorazepam Therapy in Very-Low-Birth-Weight Infants

The Initial Common Pathway of Inflammation, Disease, and Sudden Death

Establishing Drug Effects on Electrocorticographic Activity in a Genetic Absence Epilepsy Model: Advances and Pitfalls

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