Some Selenium‐Dependent Biochemical Processes

Stadtman, Thressa C.

doi:10.1002/9780470122938.ch1

Cited by 38 publications

(6 citation statements)

References 81 publications

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“…The most abundant isotopes in nature are selenium with the mass numbers 80 (49.82%) and 78 (23.52%) . Selenium with the mass number 77 has a low natural abundance (7.58%) but is stable with a nuclear spin of ½ why this isotope is useful for labelling and biophysical measurements . Due to five possible oxidation states (−2, 0, +2, +4 and +6), selenium is exceptionally well represented in a variety of compounds with diverse chemical properties.…”

Section: Chemical Propertiesmentioning

confidence: 99%

Selenium Cytotoxicity in Cancer

Wallenberg

Misra

Björnstedt

2014

Basic Clin Pharma Tox

107

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Selenium is an essential trace element with growth-modulating properties. Decades of research clearly demonstrate that selenium compounds inhibit the growth of malignant cells in diverse experimental model systems. However, the growth-modulating and cytotoxic mechanisms are diverse and far from clear. Lately, a remarkable tumour selective cytotoxicity of selenium compounds has been shown, indicating the potential of selenium in the treatment of cancer. Of particular interest are the redoxactive selenium compounds exhibiting cytotoxic potential to tumour cells. These selenium compounds elicit complex patterns of pharmacodynamics and pharmacokinetics, leading to cell death pathways that differ among compounds. Modern oncology often focuses on targeted ligand-based therapeutic strategies that are specific to their molecular targets. These drugs are initially efficient, but the tumour cells often rapidly develop resistance against these drugs. In contrast, certain redox-active selenium compounds induce complex cascades of pro-death signalling at pharmacological concentrations with superior tumour specificity. The target molecules are often the ones that are important for the survival of cancer cells and often implicated in drug resistance. Therefore, the chemotherapeutic applications of selenium offer great possibilities of multi-target attacks on tumour cells. This MiniReview focuses on the tumour-specific cytotoxic effects of selenium, with special emphasis on cascades of cellular events induced by the major groups of pharmacologically active selenium compounds. Furthermore, the great pharmacological potential of selenium in the treatment of resistant cancers is discussed.

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Section: Chemical Propertiesmentioning

confidence: 99%

Selenium Cytotoxicity in Cancer

Wallenberg

Misra

Björnstedt

2014

Basic Clin Pharma Tox

107

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“…Selenium is an essential bio-element for many bacteria, birds, fish and mammals for their survival and growth (Burau, 1985;Stadtman, 1979). The deficiency of this micronutrient has been also associated with heart failure (Ge et al, 1983;Fleming et al, 1982), muscle pain (Van Rij et al, 1979, 1981, lower risk of cancer (Ip and Ganther, 1994) and various other diseases (Burk, 1994) in humans and animals.…”

Section: Introductionmentioning

confidence: 96%

Selenium status in food grains of northern districts of India

Yadav

Singh

Sharma

et al. 2008

Journal of Environmental Management

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“…Selenium is an essential micronutrient for mammals, birds, fish and many bacteria for their growth and survival (Burau, 1985;Stadtman, 1979). In human beings and animals, its deficiency has been shown to be associated with heart failure (Ge et al, 1983;Fleming et al, 1982), muscle pain (Van Rij et al, 1981), cancer inhibitor (Ip and Ganther, 1994;Cech et al, 1984) and many other diseases (Burk, 1994).…”

Section: Introductionmentioning

confidence: 97%